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Effect of D-alpha-tocopherol on tubular nephron acidification by rats with induced diabetes mellitus BJMBR
Nascimento Gomes,G.; Barbosa,F.T.; Radaeli,R.F.; Cavanal,M.F.; Mello Aires,M.; Zaladek Gil,F..
The objective of the present study was to determine if treatment of diabetic rats with D-alpha-tocopherol could prevent the changes in glomerular and tubular function commonly observed in this disease. Sixty male Wistar rats divided into four groups were studied: control (C), control treated with D-alpha-tocopherol (C + T), diabetic (D), and diabetic treated with D-alpha-tocopherol (D + T). Treatment with D-alpha-tocopherol (40 mg/kg every other day, ip) was started three days after diabetes induction with streptozotocin (60 mg/kg, ip). Renal function studies and microperfusion measurements were performed 30 days after diabetes induction and the kidneys were removed for morphometric analyses. Data are reported as means ± SEM. Glomerular filtration rate...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Diabetes; D-alpha-tocopherol; Renal function; Nephropathy.
Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000700007
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Effects of dietary lipids on renal function of aged rats BJMBR
Valente Gamba,C.; Zeraib Caraviello,A.; Matsushita,A.; Alves,G.M.; Nunes da Silva,L.; Nascimento Gomes,G.; Zaladek Gil,F..
Normal aging is accompanied by renal functional and morphological deterioration and dietetic manipulation has been used to delay this age-related decline. We examined the effects of chronic administration of diets containing 5% lipid-enriched diet (LD, w/w) on renal function of rats at different ages. Three types of LD were tested: canola oil, fish oil and butter. Mean systemic tail-cuff blood pressure and glycemia remained within the normal range whatever the age and the diet of the animals. Proteinuria began to rise from the 8th month in the groups ingesting LD, while in the control group it increased significantly (above 10 mg/24 h) only after the 10th month. With age, a significant and progressive decline in glomerular filtration rate (GFR) and renal...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Aging; Lipids; Proteinuria; Renal function; Acid excretion; Canola oil; Fish oil.
Ano: 2001 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000200016
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