|
|
|
|
|
| Lunz,W.; Oliveira,E.C.; Neves,M.T.D.; Fontes,E.P.B.; Dias,C.M.G.C.; Natali,A.J.. |
| The present study investigated the effects of exercise and anabolic-androgenic steroids on cardiac HSP72 expression. Male Wistar rats were divided into experimental groups: nandrolone exercise (NE, N = 6), control exercise (CE, N = 6), nandrolone sedentary (NS, N = 6), and control sedentary (CS, N = 6). Animals in the NE and NS groups received a weekly intramuscular injection (6.5 mg/kg of body weight) of nandrolone decanoate, while those in the CS and CE groups received mineral oil as vehicle. Animals in the NE and CE groups were submitted to a progressive running program on a treadmill, for 8 weeks. Fragments of the left ventricle were collected at sacrifice and the relative immunoblot contents of HSP72 were determined. Heart weight to body weight ratio... |
| Tipo: Info:eu-repo/semantics/other |
Palavras-chave: Physical activity; Nandrolone; Myocardium; Heat shock protein. |
| Ano: 2006 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006000700006 |
| |
|
|
| Carneiro-Júnior,M.A.; Quintão-Júnior,J.F.; Drummond,L.R.; Lavorato,V.N.; Drummond,F.R.; Amadeu,M.A.; Oliveira,E.M.; Felix,L.B.; Cruz,J.S.; Mill,J.G.; Natali,A.J.; Prímola-Gomes,T.N.. |
| In cardiomyocytes, calcium (Ca2+) release units comprise clusters of intracellular Ca2+ release channels located on the sarcoplasmic reticulum, and hypertension is well established as a cause of defects in calcium release unit function. Our objective was to determine whether endurance exercise training could attenuate the deleterious effects of hypertension on calcium release unit components and Ca2+ sparks in left ventricular myocytes of spontaneously hypertensive rats. Male Wistar and spontaneously hypertensive rats (4 months of age) were divided into 4 groups: normotensive (NC) and hypertensive control (HC), and normotensive (NT) and hypertensive trained (HT) animals (7 rats per group). NC and HC rats were submitted to a low-intensity treadmill running... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Physical activity; Hypertension; Cardiomyocyte; Calcium handling; Sarcoplasmic reticulum. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2014001100960 |
| |
|
|
| Melo,R.T.R.; Damázio,L.C.M.; Lima,M.C.; Pereira,V.G.; Okano,B.S.; Monteiro,B.S.; Natali,A.J.; Carlo,R.J. Del; Maldonado,I.R.S.C.. |
| Physical exercise is a known preventive and therapeutic alternative for several cerebrovascular diseases. Therefore, the objective of the present study was to evaluate the motor performance and histomorphometry of the biceps brachii, soleus, and tibialis anterior muscles of rats submitted to a treadmill training program prior to the induction of cerebral ischemia via occlusion of the middle cerebral artery (OMCA). A total of 24 Wistar rats were distributed into four groups: Sham-Sed: sedentary control animals (n=6), who underwent sham surgery (in which OMCA did not occur); Sham+Ex: control animals exercised before the sham surgery (n=6); I-Sed: sedentary animals with cerebral ischemia (n=6); and I+Ex: animals exercised before the induction of ischemia... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Muscles; Cerebral ischemia; Exercise; Movement; Rats; Atrophy. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2019001200607 |
| |
|
|
| Carneiro-Júnior,M.A.; Pelúzio,M.C.G.; Silva,C.H.O.; Amorim,P.R.S.; Silva,K.A.; Souza,M.O.; Castro,C.A.; Roman-Campos,D.; Prímola-Gomes,T.N.; Natali,A.J.. |
| We determined the effects of exercise training and detraining on the morphological and mechanical properties of left ventricular myocytes in 4-month-old spontaneously hypertensive rats (SHR) randomly divided into the following groups: sedentary for 8 weeks (SED-8), sedentary for 12 weeks (SED-12), treadmill-running trained for 8 weeks (TRA, 16 m/min, 60 min/day, 5 days/week), and treadmill-running trained for 8 weeks followed by 4 weeks of detraining (DET). At sacrifice, left ventricular myocytes were isolated enzymatically, and resting cell length, width, and cell shortening after stimulation at a frequency of 1 Hz (~25°C) were measured. Cell length was greater in TRA than in SED-8 (161.30 ± 1.01 vs 156.10 ± 1.02 μm, P < 0.05, 667 vs 618 cells,... |
| Tipo: Info:eu-repo/semantics/other |
Palavras-chave: Physical activity; Inactivity; Hypertension; Cardiomyocytes. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010001100005 |
| |
|
|
| Moreira,A.P.B.; Sabarense,C.M.; Dias,C.M.G.C.; Lunz,W.; Natali,A.J.; Glória,M.B.A.; Peluzio,M.C.G.. |
| We determined the effect of fish oil (FO) ingestion on colonic carcinogenesis in rats. Male Wistar rats received 4 subcutaneous injections (40 mg/kg body weight each) of 1,2-dimethylhydrazine (DMH) at 3-day intervals and were fed a diet containing 18% by weight FO (N = 10) or soybean oil (SO, N = 10) for 36 weeks. At sacrifice, the colon was removed, aberrant crypt foci were counted and the fatty acid profile was determined. Intestinal tumors were removed and classified as adenoma or carcinoma. Liver and feces were collected and analyzed for fatty acid profile. FO reduced the mean (± SEM) number of aberrant crypt foci compared to SO (113.55 ± 6.97 vs 214.60 ± 18.61; P < 0.05) and the incidence of adenoma (FO: 20% vs SO: 100%), but carcinoma occurred... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Colonic aberrant crypt foci; Colorectal cancer prevention; Colorectal tumor; Omega-3 fatty acids; Polyamines. |
| Ano: 2009 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009001200008 |
| |
|
|
| Del Carlo,R.J.; Galvão,M.R.; Viloria,M.I.V.; Natali,A.J.; Barbosa,A.L.T.; Monteiro,B.S.; Pinheiro,L.C.P.. |
| Trinta e quatro ratos foram alocados em quatro grupos experimentais: sem imobilização (G1), com imobilização do joelho direito por 45 dias (G2), com imobilização e remobilização com atividade livre por cinco semanas (G3), imobilização e remobilização com atividade livre e natação por cinco semanas (G4). A imobilização interferiu negativamente na marcha e amplitude articular e o G4 apresentou melhor evolução na marcha nos cinco primeiros dias, em relação ao G3. Após esse período, a evolução foi similar. Os componentes do G2 apresentaram rigidez articular, não observada em G3 e G4. Histologicamente, a imobilização promoveu aumento da espessura da cápsula articular, evidenciada pela presença do tecido conjuntivo fibroso que substituiu o tecido adiposo no G2,... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Rato; Imobilização articular; Remobilização articular; Artrose. |
| Ano: 2007 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352007000200015 |
| |
|
|
| Lunz,W.; Peluzio,M.C.G.; Dias,C.M.G.C.; Moreira,A.P.B.; Natali,A.J.. |
| We determined the effect of long-term aerobic swimming training regimens of different intensities on colonic carcinogenesis in rats. Male Wistar rats (11 weeks old) were given 4 subcutaneous injections (40 mg/kg body weight each) of 1,2-dimethyl-hydrazine (DMH, dissolved in 0.9% NaCl containing 1.5% EDTA, pH 6.5), at 3-day intervals and divided into three exercise groups that swam with 0% body weight (EG1, N = 11), 2% body weight (EG2, N = 11), and 4% body weight of load (EG3, N = 10), 20 min/day, 5 days/week for 35 weeks, and one sedentary control group (CG, N = 10). At sacrifice, the colon was removed and counted for tumors and aberrant crypt foci. Tumor size was measured and intra-abdominal fat was weighed. The mean number of aberrant crypt foci was... |
| Tipo: Info:eu-repo/semantics/other |
Palavras-chave: Physical exercise Exercise intensity 1; 2-Dimethylhydrazine Colorectal carcinoma Aberrant crypt foci. |
| Ano: 2008 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008001100009 |
| |
|
|
|
