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Transmission Electron Microscopy Studies of the Vestibulocochlear Nerve in Chronic Diabetic Rats International Journal of Morphology
Vasconcelos,Carlos Augusto Carvalho de; Fazan,Valéria Paula Sassoli; Moore,Kenneth Charles; Nessler,Randy Alan; Valença,Marcelo Moraes.
It is widely described in the literature that diabetic patients present hearing impairment. Despite the histological alterations of the internal ear structures in these patients as well as in experimental models of diabetes, to the best of our knowledge, an histological evaluation of the vestibulocochlear nerve have not been performed. In the present study, ultrastructural alterations are described and compared between a spinal nerves and a cranial nerve in rats with chronic induced diabetes. Male Wistar rats (n = 12), fed with standard diet from the animal care facility at 42 days of age were used. Induced diabetic animals (n=6) were fasted for 12 hours prior to being injected intraperitoneally with streptozotocin (STZ - 60mg/kg) in a single dose. Control...
Tipo: Journal article Palavras-chave: Experimental diabetes; Vestibulocochlear nerve; Ultrastructure; Myelinated fibers; Axonal atrophy.
Ano: 2011 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022011000100045
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