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Lung Cytokine Gene Expression is Correlated with Increased Severity of Disease in a Novel H4N8 Influenza Virus Isolated from Shorebirds. OAK
ARAI, Yasuha; N. BUI, Vuong; TAKEDA, Yohei; Q. TRINH, Dai; NIBUNO, Sayo; RUNSTADLER, Jonathan; OGAWA, Haruko; IMAI, Kunitoshi; 小川, 晴子.
The lung cytokine gene expression profiles of mice infected with 2 strains of H4N8 viruses isolated from shorebirds and reference H4 viruses from ducks are compared. Major differences between the two H4N8 strains of shorebirds, one of which causes a severe respiratory disease in mice, are in the PB1 and NS1 genes. In mice with H4N8 virus induced pneumonia, overall expression of TNF-α, IL-6 and IL-12 genes was markedly higher than in mice infected with other H4 viruses tested, although gene expression of type I interferon was not increased until day 4 post viral infection. In contrast, in mice infected with a comparison H4N8 strain, gene expression of type I interferon peaked on day 1 post viral infection. Overall, the cytokine response corresponds with the...
Palavras-chave: Avian influenza virus; Cytokine; H4N8; Mouse; Pathogenicity.
Ano: 2013 URL: http://ir.obihiro.ac.jp/dspace/handle/10322/4061
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