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Stability indicating RP-HPLC method development and validation of cefepime and amikacin in pure and pharmaceutical dosage forms BJPS
Kalyani,Lella; Rao,Chava Venkata Nageswara.
A simple, accurate, isocratic stability indicating RP-HPLC method was developed for the determination of cefepime and amikacin in Pure and its pharmaceutical formulations. The method consists of methanol: acetonitrile:acetate buffer 75:20:05 (v/v) mobile phase at pH 5.1 with C18 column as stationary phase. The flow rate and detection wave length were 1.0 mL/min and 212 nm respectively. The linearity range for the method was found to be 2.5-25 µg/mL for amikacin and 10-100 µg/mL cefepime respectively. The developed method was validated as per ICH guidelines and the results of all the validation parameters were well within their acceptance values. Also the forced degradation studies were conducted with standard drugs. Degradation products formed during the...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Cefepime/method development and validation; Amikacin/method development and validation; RP-HPLC.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000300607
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