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A simple method for the quantification of diclofenac potassium in oral suspension by high-performance liquid chromatography with UV-detection BJPS
Rubim,Alexandre Machado; Rubenick,Jaqueline Bandeira; Laporta,Luciane Varine; Rolim,Clarice Madalena Bueno.
A rapid, simple and low cost method was developed to determine diclofenac potassium (DP) in oral suspension, using a reverse-phase column (C8, 150 mm x 4.6 mm, 5 µm), mobile phase containing methanol/buffer phosphate (70:30 v/v, pH 2.5), at a flow rate of 1.0 mL/min, isocratic method, and ultraviolet detection at 275 nm. A linear response (r = 1.0000) was observed in the range of 10.0-50.0 µg/mL. Validation parameters such as linearity, specificity, precision, accuracy and robustness were evaluated. The method presented precision (repeatability: relative standard deviation = 1.21% and intermediate precision: between-analyst = 0.85%). The specificity of the assay was evaluated by exposure of diclofenac potassium under conditions of stress such as...
Tipo: Info:eu-repo/semantics/article Palavras-chave: High performance liquid chromatography; Diclofenac potassium; Oral suspension.
Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000300021
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Amiodarone hydrochloride: enhancement of solubility and dissolution rate by solid dispersion technique BJPS
Rubim,Alexandre Machado; Rubenick,Jaqueline Bandeira; Gregolin,Eduarda; Laporta,Luciane Varini; Leitenberg,Rosimar; Rolim,Clarice Madalena Bueno.
abstract Amiodarone HCl is an antiarrhythmic agent, which has low aqueous solubility and presents absorption problems. This study aimed to develop inclusion complexes containing hydrophilic carriers PEG 1500, 4000 and 6000 by fusion and kneading methods in order to evaluate the increase in solubility and dissolution rate of amiodarone HCl. The solid dispersion and physical mixtures were characterized by X-ray diffraction, FT-IR spectra, water solubility and dissolution profiles. Both methods and carriers increased the solubility of drug, however PEG 6000 enhanced the drug solubility in solid dispersion better than other carriers. Different media were evaluated for the solubility study, including distilled water, acid buffer pH 1.2, acetate buffer pH 4.5...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Amiodarone hydrochloride/dissolution profile; Amiodarone hydrochloride/solid dispersion; Hydrophilic polymer..
Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502015000400957
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Cytotoxicity and antioxidant activity of goldenberry extracts obtained with high intensity ultrasound Ciência Rural
Codevilla,Cristiane Franco; Tischer,Bruna; Gindri,Amanda Leitão; Nogueira-Librelotto,Daniele Rubert; Barin,Juliano Smanioto; Silva,Cristiane de Bona da; Rolim,Clarice Madalena Bueno; Zepka,Leila Queiroz; Menezes,Cristiano Ragagnin de.
ABSTRACT: The high intensity ultrasound-assisted extraction (HIU) is one of the most simple, quick and efficient techniques for the extraction of phenolic and other antioxidant compounds from plants. This is the first application of HIU for the extraction of these compounds from goldenberry fruit. The HIU and conventional extraction techniques showed similar results regarding to phenolic compounds and antioxidant capacity. However, the time required for HIU extraction (5min) was 24 times lower than conventional extraction (120min). Phenolic compounds reported were chlorogenic acid, caffeic acid and rutin. In vitro cytotoxicity assays were used for evaluation of extracts and the results showed that in a wide range of concentration, the extract maintains...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Goldenberry; Sonication; Antioxidant capacity; Cytotoxicity; High performance liquid chromatography.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782018000200752
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Development and validation of a dissolution method using HPLC for diclofenac potassium in oral suspension BJPS
Rubim,Alexandre Machado; Rubenick,Jaqueline Bandeira; Laporta,Luciane Varini; Rolim,Clarice Madalena Bueno.
The present study describes the development and validation of an in vitro dissolution method for evaluation to release diclofenac potassium in oral suspension. The dissolution test was developed and validated according to international guidelines. Parameters like linearity, specificity, precision and accuracy were evaluated, as well as the influence of rotation speed and surfactant concentration on the medium. After selecting the best conditions, the method was validated using apparatus 2 (paddle), 50-rpm rotation speed, 900 mL of water with 0.3% sodium lauryl sulfate (SLS) as dissolution medium at 37.0 ± 0.5°C. Samples were analyzed using the HPLC-UV (PDA) method. The results obtained were satisfactory for the parameters evaluated. The method developed...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Dissolution method/development; Dissolution method/validation; Diclofenac potassium/release in oral suspensions; Oral suspension/quality control; High performance liquid chromatography/qualitative analysis.
Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000200423
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Inclusion complex of amiodarone hydrochloride with cyclodextrins: preparation, characterization and dissolution rate evaluation BJPS
Rubim,Alexandre Machado; Rubenick,Jaqueline Bandeira; Maurer,Marcela; Laporta,Luciane Varini; Rolim,Clarice Madalena Bueno.
ABSTRACT This study aimed to improve the water solubility of amiodarone hydrochloride (AMH) via inclusion complexes with β-cyclodextrin, methyl-β-cyclodextrin and 2-hydroxypropyl-β-cyclodextrin. Inclusion complexes were developed by physical mixture, coevaporation, spray-drying and freeze-drying. Solid state analysis was performed using X-ray powder diffraction, differential scanning calorimetry and scanning electronic microscopy. Thermodynamic studies demonstrate that the inclusion complexes of drug into different cyclodextrins were an exothermic process that occurred spontaneously. Water solubility and drug dissolution rates were significantly increased after the formation of inclusion complexes with the cyclodextrins evaluated in relation to the...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Amiodarone HCl/evaluation; Amiodarone HCl/solubility; Cyclodextrins/inclusion complexes; Cyclodextrins /thermodynamic studies; Dissolution rate.
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000200607
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Physicochemical characterization and evaluation of in vitro and in vivo toxicity of goldenberry extract nanoemulsion Ciência Rural
Silva,Suelen Santos da; Bazana,Maiara Taís; Deus,Cassandra de; Machado,Marina Lopes; Cordeiro,Larissa Marafiga; Soares,Félix Alexandre Antunes; Libreloto,Daniele Rubert Nogueira; Rolim,Clarice Madalena Bueno; Menezes,Cristiano Ragagnin de; Codevilla,Cristiane Franco.
ABSTRACT: Oil-in-water (O/W) nanoemulsion containing goldenberry extract was elaborated using a high-energy ultrasonic bath method. Physicochemical characterization of the formulation was carried out by determining pH, mean droplet diameter, polydispersity index (PDI) and zeta potential. Nanoemulsion toxicity was assessed using in vitro assays with tumor and non-tumor cell lines, and in vivo using Caenorhabditis elegans. The pH of the nanoemulsion was 3.84, the mean droplet diameter was 268 ± 7 nm, PDI 0.113 and zeta potential -13.94 mV. Results of the cytotoxicity assays employing non-tumor cells indicated that the extract associated or not with nanoemulsion maintained cell viability at different concentrations tested. In the assays using tumor lineage,...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Physalis peruviana; Nanoemulsion; Citotoxicity; C. elegans..
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782019000800754
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Preparation of mupirocin-loaded polymeric nanocapsules using essential oil of rosemary BJPS
Rubenick,Jaqueline Bandeira; Rubim,Alexandre Machado; Bellé,Francieli; Nogueira-Librelotto,Daniele Rubert; Rolim,Clarice Madalena Bueno.
Abstract The purpose of this study was to prepare and characterize mupirocin-loaded polymeric nanocapsules using two different oils and to develop and validate an analytical method for quantitative determination by high performance liquid chromatography. The mean size of the nanoparticles was 233.05 nm and 275.03 nm for nanocapsules with a rosemary oil like oily core and caprylic/capric triglyceride, respectively, and a good polydispersity index below 0.25 for both formulations. The nanocapsules showed good stability when stored at 40 ºC and room temperature for 30 days. The quantitative method was performed with a mobile phase consisting of ammonium ammonium acetate (0.05 M adjusted to pH 5.0 with acetic acid) and acetonitrile 60:40 (v/v); the flow rate...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Mupirocin/High Performance Liquid Chromatography; Mupirocin/Polymeric nanocapsules; Rosemary oil..
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000100623
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Stability indicating RP-LC-PDA method for the quantitative analysis of saxagliptin in pharmaceutical dosage form BJPS
Scheeren,Laís Engroff; Marcolino,Ana Isa Pedroso; Adams,Andréa Inês Horn; Rolim,Clarice Madalena Bueno.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Saxagliptin/tablets/quality control; High Performance Liquid Chromatography/quantitative analysis.
Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502015000200461
Registros recuperados: 8
Primeira ... 1 ... Última
 

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