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Acute Toxicity and Cytotoxicity Effect of Ethanolic Extract of Spondias tuberosa Arruda Bark: Hematological, Biochemical and Histopathological Evaluation Anais da ABC (AABC)
BARBOSA,HUMBERTO M.; NASCIMENTO,JAILSON N. DO; ARAÚJO,THIAGO A.S.; DUARTE,FILIPE S.; ALBUQUERQUE,ULYSSES P.; VIEIRA,JEYMESSON R.C.; SANTANA,EDSON R.B. DE; YARA,RICARDO; LIMA,CLÁUDIA S.A.; GOMES,DAYANE A.; LIRA,EDUARDO C..
ABSTRACT Spondias tuberosa Arruda, popularly named as umbu, is native from savanna-like vegetation and widely used for medicinal purposes, however, the toxicological profile is not available yet. This study evaluated the phytochemical profile and acute toxicity and citoxicity of Ethanolic Extract of Spondias tuberosa Arruda Bark (EEStb) in hematological, biochemical and histopathological parameters. Female Wistar rats were divided into: control (C) and animal treated single doses of 300mg/Kg (EEStb300) or 2.000mg/kg body weight (ESStb2.000) of the EEStb. After 24 hours and 14 days from gavage, the behavior, hematological, biochemical and histopathological parameters were assayed. Cytotoxicity effect was evaluated on HEp-2 cell lines. Neither EEStb300 nor...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Acute toxicity; Cytotoxicity; Phytomedicine; Safety; Spondias tuberosa Arruda; Toxicology.
Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652016000501993
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Evaluation of cytotoxicity and wound healing activity of Avicennia schaueriana in cream Anais da ABC (AABC)
LOPES,CAROLINE M.I.; BARATELLA-EVÊNCIO,LIRIANE; SOUZA,IVONE A. DE; OLIVEIRA,ERWELLY B. DE; SÁ,JÉSSICA G.A.; SANTANA,MARLLON A.N.; MARCELINO NETO,PEDRO P.; SANTANA,EDUARDA S. DE; SILVA,LUZIA A. DA; VIEIRA,JEYMESSON R.C..
Abstract:Avicennia schaueriana is found in Brazilian mangrove coast. The cytotoxicity in vitro of the Aqueous Extract of Leaves of Avicennia schaueriana (AELAs) and the healing activity of the plant in cream on mice skin wounds were evaluated in this study. The cytotoxic evaluation was performed on Vero cells. The healing activity was evaluated on mice treated during 5, 10 and 15 days with cream at 5%, solution of sodium chloride at 0.9% and dexpanthenol in cream at 5%. The extract did not show cytotoxicity, but showed mitogenic activity (100μg/ml). In morphometric analysis, the percentage of wound contraction after 10 days was higher in dexpanthenol group (93.41%). In 15 days, the lowest percentage of contraction was observed in the dexpanthenol group...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Avicennia schaueriana; In vitro techniques; Re-epithelialization; Vero cells; Wound healing.
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000100805
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Evaluation of embryotoxic and embryostatic effects of the aqueous extract of Rhizophora mangle and tannic acid on eggs and larvae of Aedes aegypti Anais da ABC (AABC)
RODRIGUES NETO,AGEU A.; GOMES JÚNIOR,PLÍNIO P.; SILVA,MAURICIO C.; LIMA,CLÁUDIA S.A.; YARA,RICARDO; GUIMARÃES,EMÍLIA B.; SANTANA,EDUARDA S. DE; SILVA,LUZIA A. DA; LIRA,EDUARDO J.R.V. DE; VIEIRA,JEYMESSON R.C..
ABSTRACT Rhizophora mangle is an abundant plant in mangroves and tannic acid is a polyphenol produced by the secondary metabolism of plants. The aim of the study was to evaluate the embryotoxic and embriostatic effects of the aqueous extract of R. mangle and synthetic tannic acid on eggs and larvae of Aedes aegypti. A. aegypti eggs were exposed in duplicate at concentrations of 250, 500, 750 and 1000 µg/mL of extract and tannic acid for a period of 14 days. Mineral water was used as a negative control. The eggs were observed and counted in a stereomicroscope (1.2x). In all extract concentrations there was stimulation in hatching in relation to the control, but only in concentration of 750 mg/mL it was statistically significant. In tannic acid (250µg/ml)...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Aedes aegypti; Embryostatic; Embryotoxic; Rhizophora mangle; Tannic acid.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000502141
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Phytochemical Screening and Acute Toxicity of Aqueous Extract of Leaves of Conocarpus erectus Linnaeus in Swiss Albino Mice Anais da ABC (AABC)
NASCIMENTO,DAYANE K.D.; SOUZA,IVONE A. DE; OLIVEIRA,ANTÔNIO F.M. DE; BARBOSA,MARIANA O.; SANTANA,MARLLON A.N.; PEREIRA JÚNIOR,DANIEL F.; LIRA,EDUARDO C.; VIEIRA,JEYMESSON R.C..
ABSTRACT Mangroves represent areas of high biological productivity and it is a region rich in bioactive substances used in medicine production. Conocarpus erectus (Combretaceae) known as button mangrove is one of the species found in mangroves and it is used in folk medicine in the treatment of anemia, catarrh, conjunctivitis, diabetes, diarrhea, fever, gonorrhea, headache, hemorrhage, orchitis, rash, bumps and syphilis. The present study aimed to investigate the acute toxicity of aqueous extract of leaves of C. erectus in Swiss albino mice. The plant material was collected in Vila Velha mangroves, located in Itamaracá (PE). The material was subjected to a phytochemical screening where extractive protocols to identify majority molecules present in leaves...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Acute toxicity; Aqueous extract; Conocarpus erectus; Medicinal plants; Plants extracts.
Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652016000401431
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