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Association of angiotensin-converting enzyme activity and polymorphism with echocardiographic measures in familial and nonfamilial hypertrophic cardiomyopathy BJMBR
Buck,P.C.; Fernandes,F.; Arteaga,E.; Matsumoto,A.Y.; Araujo,A.Q.; Oliveira,E.M.; Ianni,B.M.; Ramires,F.J.A.; Krieger,J.E.; Mady,C..
Angiotensin-converting enzyme (ACE) activity and polymorphism contribute significantly to the prognosis of patients with cardiomyopathy. The aim of this study was to determine the activity and type of ACE polymorphism in patients with familial and nonfamilial hypertrophic cardiomyopathy (HCM) and to correlate these with echocardiographic measurements (echo-Doppler). We studied 136 patients (76 males) with HCM (69 familial and 67 nonfamilial cases). Mean age was 41 ± 17 years. DNA was extracted from blood samples for the polymerase chain reaction and the determination of plasma ACE levels. Left ventricular mass, interventricular septum, and wall thickness were measured. Mean left ventricular mass index, interventricular septum and wall thickness in familial...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Echocardiography; ACE activity; ACE polymorphism; Hypertrophic cardiomyopathy; Left ventricular mass index.
Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000800005
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Standardization of a fluorimetric assay for the determination of tissue angiotensin-converting enzyme activity in rats BJMBR
Oliveira,E.M.; Santos,R.A.S.; Krieger,J.E..
The tripeptide Hip-His-Leu was used to standardize a fluorimetric method to measure tissue angiotensin-converting enzyme (ACE) activity in rats. The fluorescence of the o-phthaldialdehyde-His-Leu adduct was compared in the presence and absence of the homogenate (25 µl) to determine whether the homogenate from different tissues interfered with the fluorimetric determination of the His-Leu product. Only homogenates from lung and renal medulla and cortex showed significantly altered fluorescence intensity. To overcome this problem, the homogenate from these tissues were diluted 10 times with assay buffer. The specificity of the assay was demonstrated by the inhibition of ACE activity with 3 µM enalaprilat (MK-422). There was a linear relationship between...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Angiotensin-converting enzyme; ACE activity; Fluorimetric assay; Rat tissues.
Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000700005
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