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Registros recuperados: 28
Primeira ... 12 ... Última
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Acute oral toxicity and anti-inflammatory activity of hydroalcoholic extract from Lampaya medicinalis Phil in rats Biol. Res.
Morales,Glauco; Paredes,Adrián; Olivares,Alberto; Bravo,Jaime.
BACKGROUND: Algesia and inflammation are related with several pathological conditions. It is known that many drugs available for the treatment of these problems cause unwanted side effects. This study was aimed at evaluating acute toxicity and anti-inflammatory activity of Lampaya medicinalis Phil. (Verbenaceae) widely used in the folk medicine of Northern Chile against rheumatism, arthritis and body joints pain. RESULTS: Oral administration of hydroalcoholic extract (HAE) at the highest dose of 3000 mg/ Kg body weight resulted in no mortalities or evidence of significant behavioral changes. Histological examination revealed normal architecture and no significant adverse effects were observed on the liver, kidney, heart, lung or ovaries and testicles. The...
Tipo: Journal article Palavras-chave: Lampaya medicinalis; Hydroalcoholic extract; Acute oral toxicity; Histology; Hematology; Anti-inflammatory; Carrageenan.
Ano: 2014 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602014000100006
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Amburanins A and B from Amburana cearensis: Daphnodorin-type biflavonoids that modulate human neutrophil degranulation. Repositório Alice
CANUTO, K. M.; LEAL, L. K. A. M.; LOPES, A. A.; COLEMAN, C. M.; FERREIRA, D.; SILVEIRA, E. R..
Tipo: Artigo em periódico indexado (ALICE) Palavras-chave: Amburana cearensis; Anti-inflamatório; Biflavonóides; Amburana cearensis; Anti-inflammatory; Myeloperoxidase; Biflavonóides.
Ano: 2014 URL: http://www.alice.cnptia.embrapa.br/handle/doc/990985
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Anti-inflammatory activity and identification of the Verbena litoralis Kunth crude extract constituents BJPS
Lima,Rachel de; Brondani,Juliana Calil; Dornelles,Rafaela Castro; Lhamas,Cibele Lima; Faccin,Henrique; Silva,Carine Viana; Dalmora,Sérgio Luiz; Manfron,Melânia Palermo.
Verbena litoralis is a plant popularly known as “gervãozinho-do-campo” in Portuguese. It is traditionally used for stomach, liver and gallbladder problems, and as an anti-inflammatory and anthelmintic. The goal of this study was to determine the chemical composition of the crude extract obtained from the aerial parts of V. litoralis by Ultra High Performance Liquid chromatography coupled with Mass Spectrometry in Tandem (UHPLC-MS/MS); assess the anti-inflammatory activity of ethyl acetate fraction and of crude extract; and verify liver, kidney and pancreas damage. In this study, the chemical composition of the extract was identified via UHPLC/MS/MS, assessing the anti-inflammatory activity of the crude extract and the acetate fraction in an induction model...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Verbena litoralis; UHPLC/MS; Flavonoids; Anti-inflammatory.
Ano: 2020 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100540
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Anti-inflammatory and redox-protective activities of citronellal Biol. Res.
Melo,Mônica S; Guimarães,Adriana G; Santana,Michele F; Siqueira,Rosana S; De Lima,Amanda Do Carmo B; Dias,Antonio S; Santos,Márcio Roberto V; Onofre,Alexandre S.C.; Quintans,Jullyana S.S.; De Sousa,Damião P; Almeida,Jackson R.G.S.; Estevam,Charles S; Araujo,Brancilene S; Quintans-Júnior,Lucindo J.
The anti-inflammatory and redox protective effects of the citronellal (CT) were evaluated using in vivo and in vitro tests. Intraperitoneal (i.p.) administration of CT (50, 100, and 200 mg/kg) inhibited (p < 0.05) the carrageenan-induced leukocyte migration to the peritoneal cavity. Additionally, the carrageenan- and arachidonic acid-induced rat hind paw edema was significantly inhibited (p < 0.05) by i.p. administration of 100 and 200 mg/kg of the compound. When the redox activity was evaluated, CT (200 mg/kg) significantly reduced hepatic lipoperoxidation (p < 0.001), as well as oxidation of plasmatic (p < 0.05) and hepatic (p < 0.01) proteins. The results of the present study support the hypothesis that CT possesses anti-inflammatory and...
Tipo: Journal article Palavras-chave: Monoterpene; Citronellal; Anti-inflammatory; Redox.
Ano: 2011 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602011000400008
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Anti-inflammatory, antinociceptive, and antipyretic effects of methanol extract of Cariniana rubra stem bark in animal models Anais da ABC (AABC)
Santos,Edson N.; Lima,Joaquim C.S.; Noldin,Vânia F.; Cechinel-Filho,Valdir; Rao,Vietla S. N.; Lima,Evangelista F.; Schmeda-Hirschmann,Guillermo; Sousa Jr.,Paulo T.; Martins,Domingos T.O..
Cariniana rubra Miers (Lecythidaceae), popularly known as "jequitibá-vermelho'', is a large Brazilian tree whose bark is used in infusion and decoction for the treatment of inflammatory conditions. This study aims to assess the anti-inflammatory, antinociceptive, and antipyretic effects of Cariniana rubra methanolic stem bark extract (EM Cr) using experimental animals. Anti-inflammatory activity of EM Cr was tested on carrageenan and dextran-induced rat paw edema, carrageenan-induced pleurisy in rats and acetic acid-increase vascular permeability in mice. Antinociceptive and antipyretic activities were evaluated using acetic acid-induced writhing, formalin and hot-plate tests in mice, as well as brewer's yeast-induced pyrexia in rats. The extract...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Anti-inflammatory; Antinociceptive; Antipyretic; Cariniana rubra; Lecythidaceae; Triterpenoidal saponins.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652011000200015
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Anti-inflammatory effects of Salvia plebeia R. Br extract in vitro and in ovalbumin-induced mouse model Biol. Res.
Hwan-Hee,Jang; Su-Yeon,Cho; Mi-Ju,Kim; Jung-Bong,Kim; Sung-Hyen,Lee; Mee-Young,Lee; Young-Min,Lee.
BACKGROUND: Asthma is an increasing global health problem, and novel strategies to prevent or ameliorate the condition are needed. Here, the effects of 80 % ethanol extracts of Salvia plebeia R. Br. (SE) on an induced inflammatory response were investigated RESULTS: Salvia plebeia R. Br. inhibited production of pro-inflammatory cytokines, such as TNF-&#945; and IL-6, as well as nitric oxide (NO) in LPS-stimulated RAW 264.7 cells. NO and pro-inflammatory cytokine production was suppressed more effectively by SE of the aerial parts (SE-A) than of the roots (SE-R) of S. plebeia. In BEAS-2B cells, both SE-A and SE-R inhibited the increase in production of the inflammatory cytokines IL-6 and IL-8. We also investigated the antiasthmatic effects of SE in an...
Tipo: Journal article Palavras-chave: Anti-inflammatory; Asthma; Salvia plebeia.
Ano: 2016 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602016000100041
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Antioxidant and anti-inflammatory activities of winery wastes seeds of Vitis labrusca Ciência Rural
Scola,Gustavo; Kappel,Virginia Demarchi; Moreira,José Claudio Fonseca; Dal-Pizzol,Felipe; Salvador,Mirian.
There are many studies about the biological activities of Vitis vinifera grape seeds, which are rich in phenolic compounds, known by their several health beneficial effects. However, until now there is no data about biological activities of the seeds of V. labrusca, specie found in South and North America. Every year, the global wine production (around 260 million hL) generates about 19.5 million ton of wastes, which are usually discarded in the environment. The aim of this research was to evaluate the antioxidant and anti-inflammatory activities of aqueous extracts of seeds from wine wastes of Vitis labrusca (cv. 'Bordo' and 'Isabella'). Both extracts showed significant antioxidant and anti-inflammatory activities, which are positively correlated with...
Tipo: Info:eu-repo/semantics/article Palavras-chave: V. labrusca; Winery wastes; Antioxidant; Anti-inflammatory.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782011000700020
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Antioxidant effect of quinoline derivatives containing or not selenium: Relationship with antinociceptive action quinolines are antioxidant and antinociceptive Anais da ABC (AABC)
WILHELM,ETHEL A.; FERREIRA,ANA TERESINHA; PINZ,MIKAELA P.; REIS,ANGÉLICA S. DOS; VOGT,ANE G.; STEIN,ANDRE L.; ZENI,GILSON; LUCHESE,CRISTIANE.
ABSTRACT The present study investigated the antioxidant effect of a new class of quinoline derivatives (a-d) on assays in vitro. Lipid peroxidation, thiol peroxidase-like and free radical scavenging activities were determined to evaluate antioxidant activity of compounds. Thiol oxidase-like and δ-aminolevulinate dehydratase activities were performed as a toxicological parameter. A second objective of this study was to evaluate the in vivo antinociceptive effect of the compound with better antioxidant effect and without toxic effects in a model of nociception induced by formalin in mice. In liver, at 100 µM, compound a reduced the lipid peroxidation to the control levels, while compounds c and d partially reduced it. In brain, only compound d partially...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Antinociceptive; Antiedematogenic; Anti-inflammatory; Antioxidant; Quinoline.
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000200457
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Assessment of pharmacological activities of two medicinal plant of Bangladesh: Launaea sarmentosa and Aegialitis rotundifolia roxb in the management of pain, pyrexia and inflammation Biol. Res.
Raju,Golam Sarwar; Moghal,Md Mizanur Rahman; Hossain,Mohammad Salim; Hassan,Md Mahadi; Billah,Md Mustahsan; Ahamed,Sayed Koushik; Rana,SM Masud.
BACKGROUND: The current study aims at evaluating the analgesic, anti-pyretic and anti-inflammatory properties of methanolic extract of the stem, bark and leaves of Launaea sarmentosa and Aegialitis rotundifolia roxb. RESULTS: The AELS and AEAR extract presented a significant (***p < 0.001) dose dependent increase in reaction time in writhing method and showed inhibition of 63.1% and 57.1% respectively at the doses of 400 mg/kg body weight while standard drug showed (P < 0.001) inhibition of 69.23%. In tail immersion method, AELS and AEAR showed maximum time of tail retention at 30 min in hot water i.e. 6.93 sec and 6.54 sec respectively at highest doses of 400 mg/kg body weight than lower dose while standard pentazocine showed reaction time of 7.62...
Tipo: Journal article Palavras-chave: Launaea sarmentosa; Aegialitis rotundifolia roxb; Analgesic; Antipyretic; Anti-inflammatory.
Ano: 2014 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602014000100049
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Bioactivities of the ethanol extract from Ageratum fastigiatum branches: antioxidant, antinociceptive and anti-inflammatory Anais da ABC (AABC)
DEL-VECHIO-VIEIRA,GLAUCIEMAR; SANTOS,BRUNA C.S.; ALVES,MARIA SILVANA; ARAÚJO,AÍLSON L.A.; YAMAMOTO,CÉLIA H.; PINTO,MÍRIAM A.O.; KAPLAN,MARIA AUXILIADORA C.; SOUSA,ORLANDO V..
ABSTRACT The present study was designed to investigate the antioxidant, antinociceptive and anti-inflammatory activities of the ethanol extract from Ageratum fastigiatum branches. Phytochemical screening and total phenol and flavonoid contents were determined. The antioxidant activity was assessed by 2,2-diphenyl-1-pycrilhydrazin (DPPH) and iron reducing power methods. The antinociceptive effect was evaluated using the acetic acid-induced writhing, formalin, hot plate and tail immersion assays; while the carrageenan-induced paw edema and pleurisy tests were performed to examine the anti-inflammatory activity against acute inflammation. The extract revealed the presence of flavonoids, tannins, coumarins, terpenes, sterols and saponins. Expressive levels of...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Ageratum fastigiatum; Analgesic; Anti-inflammatory; Antioxidant; Flavonoids; Total phenols.
Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652016000401471
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Cytotoxic and Anti-Inflammatory Effects of Ent-Kaurane Derivatives Isolated from the Alpine Plant Sideritis hyssopifolia ArchiMer
Aimond, Axelle; Calabro, Kevin; Audoin, Coralie; Olivier, Elodie; Dutot, Mélody; Buron, Pauline; Rat, Patrice; Laprévote, Olivier; Prado, Soizic; Roulland, Emmanuel; Thomas, Olivier P.; Genta-jouve, Grégory.
This paper reports the isolation and structural characterization of four new ent-kaurane derivatives from the Lamiaceae plant Sideritis hyssopifolia. Planar structures and relative configurations were determined using both mass spectrometry and nuclear magnetic resonance (1D and 2D). Absolute configurations were determined by comparing experimental and theoretical electronic circular dichroism spectra. The cytotoxic and microbial activities of all new compounds were tested. Compounds that were non-cytotoxic were further evaluated for anti-inflammatory activity.
Tipo: Text Palavras-chave: Sideritis hyssopifolia; Ent-kaurane; Anti-inflammatory; NMR.
Ano: 2020 URL: https://archimer.ifremer.fr/doc/00610/72214/71012.pdf
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Evaluation of analgesic and anti-inflammatory activities of Hydrocotyle umbellata L., Araliaceae (acariçoba) in mice Anais da ABC (AABC)
FLORENTINO,IZIARA F.; NASCIMENTO,MARCUS VINÍCIUS M.; GALDINO,PABLINNY M.; BRITO,ADRIANE F. DE; ROCHA,FABIO F. DA; TONUSSI,CARLOS R.; LIMA,THEREZA CHRISTINA M. DE; PAULA,JOSÉ R. DE; COSTA,ELSON A..
The Hydrocotyle umbellata L. is a specimen of the Araliaceae family popularly known as acariçoba. Its indications in folk medicine include treatment of skin ulcers, and rheumatism. The aim of this study was to evaluate the antinociceptive and anti-inflammatory activities of the ethanolic extract from acariçoba's underground parts (EEA). EEA reduced the nociceptive response of the animals as evaluated in the acetic acid-induced writhing test and in both phases of formalin test. EEA also presented a supraspinal analgesic activity by increasing the pain latency in the hot plate test. Moreover, EEA reduced the leukocytes migration and plasma extravasation to pleural cavity in the carrageenan-induced pleurisy, besides reducing the edema induced by carrageenan...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Acariçoba; Anti-inflammatory; Antinociceptive; Biomedical Sciences; Hydrocotyle umbellata L.
Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652013000300987
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Evaluation of the antiedematogenic activity of artemetin isolated from Cordia curassavica DC BJMBR
Bayeux,M.C.; Fernandes,A.T.; Foglio,M.A.; Carvalho,J.E..
The species Cordia curassavica (Boraginaceae), known popularly as "erva baleeira", is used in folk medicine for the treatment of several inflammatory processes and as a healing agent. The objective of the present study was to evaluate the antiedematogenic activity of crude dichloromethane extracts of Cordia curassavica and of the artemetin-enriched fraction. The crude extract and artemetin fraction were tested in the model of carrageenin-induced paw edema in male Swiss mice (25-30 g). The crude dichloromethane extract (300 and 1000 mg/kg, po, N = 6) showed significant antiedematogenic activity, reducing the edema by 42, 57 and 45% and 46, 62 and 69%, 3, 4 and 5 h after carrageenin administration, respectively. Indomethacin (10 mg/kg, po, N = 6) reduced the...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Cordia curassavica; Cordia verbenaceae; Antiedematogenic; Anti-inflammatory; Medicinal plants.
Ano: 2002 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002001000017
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Evaluation of the anti-inflammatory and antinociceptive activities of Marsypianthes sp. essential oil. Repositório Alice
NASCIMENTO. T. S.; CARVALHO, P. R.; SILVA, R. F.; ALVES, R. B. N.; GOMES, I. S.; SILVA, D. B.; VIEIRA, R. F.; BIZZO, H. R.; REZENDE, C. M.; FERNANDES, P. D.; CORDEIRO, N. M..
2015
Tipo: Resumo em anais de congresso (ALICE) Palavras-chave: Marsypianthes sp; Anti-inflammatory; Antinociceptive effect.
Ano: 2015 URL: http://www.alice.cnptia.embrapa.br/handle/doc/1029352
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Fatty acid composition of vegetable oil blend and in vitro effects of pharmacotherapeutical skin care applications BJMBR
Guidoni,M.; de Christo Scherer,M.M.; Figueira,M.M.; Schmitt,E.F.P.; de Almeida,L.C.; Scherer,R.; Bogusz,S.; Fronza,M..
Vegetable oils have been used for a plethora of health benefits by their incorporation in foods, cosmetics, and pharmaceutical products, especially those intended for skin care. This study aimed to investigate the cutaneous benefits of a vegetable oil blend (VOB) formulation and its fatty acid composition. The anti-inflammatory activity was studied in macrophages of RAW 264.7 cells by investigating the release of nitric oxide (NO), superoxide anion generation (O2-), tumor necrosis factor-alpha (TNF-α), and interleukin 6 (IL-6). ABTS cation radical scavenging capacity assay, ferric reducing antioxidant potential (FRAP), 2,2-diphenyl-1-picrylhydrazyl (DPPH), and NO free radical scavenging assays were used to evaluate the antioxidant activity. VOB was tested...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Vegetable oil blend; Skin care; Fatty acids; Anti-inflammatory; Nitric oxide; Scratch assay.
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2019000200609
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In vitro anti-inflammatory, cytotoxic and antioxidant activities of boesenbergin A, a chalcone isolated from Boesenbergia rotunda (L.) (fingerroot) BJMBR
Isa,N.M.; Abdelwahab,S.I.; Mohan,S.; Abdul,A.B.; Sukari,M.A.; Taha,M.M.E.; Syam,S.; Narrima,P.; Cheah,S.Ch.; Ahmad,S.; Mustafa,M.R..
The current in vitro study was designed to investigate the anti-inflammatory, cytotoxic and antioxidant activities of boesenbergin A (BA), a chalcone derivative of known structure isolated from Boesenbergia rotunda. Human hepatocellular carcinoma (HepG2), colon adenocarcinoma (HT-29), non-small cell lung cancer (A549), prostate adenocarcinoma (PC3), and normal hepatic cells (WRL-68) were used to evaluate the cytotoxicity of BA using the MTT assay. The antioxidant activity of BA was assessed by the ORAC assay and compared to quercetin as a standard reference antioxidant. ORAC results are reported as the equivalent concentration of Trolox that produces the same level of antioxidant activity as the sample tested at 20 µg/mL. The toxic effect of BA on...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Boesenbergia rotunda; Boesenbergin A; Cytotoxicity; Antioxidation; Anti-inflammatory.
Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000600008
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In vivo analgesic, antipyretic, and anti-inflammatory potential in Swiss albino mice and in vitro thrombolytic activity of hydroalcoholic extract from Litsea glutinosaleaves Biol. Res.
Bhowmick,Rumpa; Sarwa,Md Shahid; Dewan,Syed Masudur Rahman; Das,Abhijit; Das,Binayok; Uddin,Mir Muhammad Nasir; Islam,Md Siddiqul; Islam,Mohammad Safiqul.
BACKGROUND: The study was conducted to evaluate the in vitro thrombolytic activity, and in vivo analgesic, anti-inflammatory and antipyretic potentials of different hydrocarbon soluble extracts of Litsea glutinosaleaves for the first time widely used in the folkloric treatments in Bangladesh. This work aimed to create new insights on the fundamental mechanisms of the plant extracts involved in these activities. RESULTS: In thrombolytic activity assay, a significant clot disruption was observed at dose of 1 mg/mL for each of the extracts (volume 100 &#956;L) when compared to the standard drug streptokinase. The n-hexane, ethyl acetate, chloroform, and crude methanolic extracts showed 32.23&#8201;±&#8201;0.26, 37.67&#8201;±&#8201;1.31,...
Tipo: Journal article Palavras-chave: Acetic acid induced writhing; Analgesic; Anti-inflammatory; Antipyretic; Litsea glutinosa; Thrombolytic.
Ano: 2014 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602014000100050
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In vivo antipyretic, antiemetic, in vitro membrane stabilization, antimicrobial, and cytotoxic activities of different extracts from Spilanthes paniculata leaves Biol. Res.
Hossain,Mohammad Mobarak; Ahamed,Sayed Koushik; Dewan,Syed Masudur Rahman; Hassan,Md Mahadi; Istiaq,Arif; Islam,Mohammad Safiqul; Moghal,Md Mizanur Rahman.
BACKGROUND: The study was conducted to evaluate the in vitro antimicrobial activity, cytotoxic, and membrane stabilization activities, and in vivo antiemetic and antipyretic potentials of ethanolic extract, n-hexane and ethyl acetate soluble fractions of Spilanthes paniculata leaves for the first time widely used in the traditional treatments in Bangladesh. RESULTS: In antipyretic activity assay, a significant reduction (P < 0.05) was observed in the temperature in the mice tested. At dose 400 mg/kg-body weight, the n-hexane soluble fraction showed the effect (36.7 ± 0.63°C ) as like as the standard (dose 150 mg/kg-body weight) after 5 h of administration. Extracts showed significant (P < 0.001) potential when tested for the antiemetic activity...
Tipo: Journal article Palavras-chave: Antiemetic; Anti-inflammatory; Antimicrobial activity; Brine shrimp lethality bioassay; Cytotoxic; Membrane stabilization; Spilanthes paniculata.
Ano: 2014 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602014000100045
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LC-ESI-IT-MS/MS and MALDI-TOF approach: identification of natural polymers from rhizophora mangle barks and determination of their analgesic and anti-inflammatory properties. Repositório Alice
MESQUITA, L. M. de S.; RODRIGUES, C. F. B.; ROCHA, C. Q. da; BIANCHIM, M. S.; RODRIGUES, C. M.; OLIVEIRA, V. de; GAETA, H. H.; BELCHOR, M. N.; TOYAMA. M. H.; VILEGAS, W..
We recognize the chemical composition of the acetonic extract of Rhizophora mangle barks (AERM) using mass spectrometry analysis [liquid chromatography (LC)?ESI?IT-MS/MS and matrix-assisted laser desorption/ionization-time of flight-MS (MALDI-TOF)]. Analgesic activity was evaluated by formalin and tail-flick experimental assays. Anti-inflammatory activity was performed by paw edema test induced by carrageenan and 48/80 compounds. The first series of experiments involved [LC]?FIA?IT-MS/MS with 11 separated catechins derivatives until degree of polymerization 3 (DP3). The spectra obtained by MALDI-TOF analysis of the AERM presented two homologous series: one based on polymers of m/z 288 Da increments (up to DP12) and another series based on polymers of m/z...
Tipo: Artigo em periódico indexado (ALICE) Palavras-chave: Morphine-like effect; Catechins; Anti-inflammatory; Mangroves.
Ano: 2019 URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1107120
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Nephroprotective and anti-inflammatory effects of aqueous extract of Melissa officinalis L. on acetaminophen-induced and pleurisy-induced lesions in rats BABT
Müzell,Denise Pereira; Lunardelli,Adroaldo; Leite,Carlos Eduardo; Fagundes,Rodrigo Medeiros; Saciura,Vasyl Custódio; Reichel,Carlos Luiz; Oliveira,Jarbas Rodrigues de; Astarita,Leandro Vieira.
This study assessed the bioactive properties of an aqueous extract of M. officinalis for its anti-inflammatory activity and its protection against hepatic and renal lesions induced by acetaminophen (APAP). Animals pre-treated with the crude extract in pleurisy induced by carrageenan showed a reduction in the amounts of exudate, in the numbers of leukocytes and polymorphonuclear cells. Intragastric administration of the extract for seven days prior to the APAP-induced lesion showed no protective effect on the liver. The treatment with the extract induced an increase of serum aspartate aminotransferase, indicating a rise of toxicity. Contrarily, the same treatment reduced the APAP induced lesion in kidney, with respect to ν-glutamyltransferase. The results...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Acetaminophen; Melissa officinalis; Pleurisy; Anti-inflammatory; Kidney; Liver.
Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132013000300006
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