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| SANTOS, S. N.; KAVAMURA, V.; CASTANHA, R. F.; ANDREOTE, F. D.; CARVALHO, J. E.; QUEIROZ, S. C. do N. de; MELO, I. S. de. |
| This investigation describes the anticancer, antioxidant and antimicrobial properties of the extracts of Combretum rupicola, a native plant from Northeast of Brazil. Methanolic, ethyl acetate and chloroform extracts from leaves of C. rupicola were evaluated in relation to their potential in inhibiting the cell growth and cytotoxic properties against nine human cancer cell lines (MCF-7, NCI-ADR/RES, OVCAR-3, PC-3, HT-29, NCIH460, 786-O, UACC-62, K-562). In addition, antioxidant activity of these extracts was measured using DPPH as radical scavenging assay and the ntimicrobial activities against nine pathogens were tested by agar diffusion method. Preliminary results showed that the this plant demonstrates to have moderate activity against bacteria but, on... |
| Tipo: Artigo em periódico indexado (ALICE) |
Palavras-chave: Combretum rupicola; Planta medicinal; Extrato vegetal; Plant extracts; Medicinal plants; Antioxidant activity; Antineoplastic agents. |
| Ano: 2013 |
URL: http://www.alice.cnptia.embrapa.br/handle/doc/950033 |
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| DELOU,JOÃO M.A.; BIASOLI,DEBORAH; BORGES,HELENA L.. |
| ABSTRACT Physiological processes, as autophagy, proliferation and apoptosis are affected during carcinogenesis. Restoring cellular sensitivity to apoptotic stimuli, such as the antineoplastic cocktails, has been explored as a strategy to eliminate cancer cells. Autophagy, a physiological process of recycling organelles and macromolecules can be deviated from homeostasis to support cancer cells survival, proliferation, escape from apoptosis, and therapy resistance. The relationship between autophagy and apoptosis is complex and many stimuli can induce both processes. Most chemotherapeutic agents induce autophagy and it is not clear whether and how this chemotherapy-induced autophagy might contribute to resistance to apoptosis. Here, we review current... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Retinoblastoma; Neoplasm; Autophagy; Cell death; Antineoplastic agents. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652016000602257 |
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