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Analysis of quantitative traits using regression and log-linear modeling when phase is unknown 31
Mander, Adrian P..
This function models the relationship between quantitative trait and the genotype of a person. It introduces a new syntax for model specification, which is necessary because when phase is unknown, the explanatory variables for the linear regression are never observed. The data must be a population-based sample because within family effects are not modeled.
Tipo: Journal Article Palavras-chave: Haplotype analysis; Association studies; Phase-unknown; Linear regression; Research Methods/ Statistical Methods.
Ano: 2002 URL: http://purl.umn.edu/115951
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Genetic diversity, population structure and AFLP markers associated with maize reaction to southern rust 53
Giordani,Willian; Scapim,Carlos Alberto; Ruas,Paulo Maurício; Ruas,Claudete de Fátima; Contreras-Soto,Rodrigo; Coan,Marlon; Fonseca,Inês Cristina de Batista; Gonçalves,Leandro Simões Azeredo.
ABSTRACT Maize is one of the species with greater genetic diversity among cereals and possibly the most diverse crop species known. Accessing this variability is essential for maize breeding, allowing breeders to achieve progress of yield increasing, overcome environmental challenges or deal with pests and diseases. Among the maize diseases, southern rust is one of the most important, causing significant losses in yield and presenting severe epidemics worldwide. In the present study, the AFLP technique was applied to analyze population structure and genetic diversity among 145 tropical maize inbred lines, and to test for preliminary evidence of association between AFLP markers and the reaction to southern rust. Disease severity was evaluated in two crop...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Zea mays; Gwas; Association studies; Cluster analysis; Genetic distance; Puccinia polysora.
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0006-87052019000200183
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Low density genomic data for animal breeding: critical analysis and perspectives of the GoldenGate Beadxpress technology 65
Araújo,Ronyere Olegário de; Caetano,Alexandre Rodrigues.
ABSTRACT: The increasing development of DNA sequencing and genotyping technologies has made possible to analyze the genomes of several species. Genomic studies of production animals have greatly increased the understanding of mechanisms that control the interactions of genetic and environmental factors involved in the expression of traits of economic importance. Several technologies have been presented by different companies for the genotyping of low-density SNP panels, which may be used in different applications with different goals, such as paternity testing, diagnosis of genetic diseases, and identification of genetically superior animals based on polymorphisms characterized in candidate genes. The present review critically analyzes the GoldenGate...
Tipo: Info:eu-repo/semantics/article Palavras-chave: SNP genotyping; GoldenGate technology; Haplotypic blocks; Custom SNP panels; Association studies.
Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782016001102005
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Mendelian breeding units versus standard sampling strategies: mitochondrial DNA variation in southwest Sardinia 74
Sanna,Daria; Pala,Maria; Cossu,Piero; Dedola,Gian Luca; Melis,Sonia; Fresu,Giovanni; Morelli,Laura; Obinu,Domenica; Tonolo,Giancarlo; Secchi,Giannina; Triunfo,Riccardo; Lorenz,Joseph G.; Scheinfeldt,Laura; Torroni,Antonio; Robledo,Renato; Francalacci,Paolo.
We report a sampling strategy based on Mendelian Breeding Units (MBUs), representing an interbreeding group of individuals sharing a common gene pool. The identification of MBUs is crucial for case-control experimental design in association studies. The aim of this work was to evaluate the possible existence of bias in terms of genetic variability and haplogroup frequencies in the MBU sample, due to severe sample selection. In order to reach this goal, the MBU sampling strategy was compared to a standard selection of individuals according to their surname and place of birth. We analysed mitochondrial DNA variation (first hypervariable segment and coding region) in unrelated healthy subjects from two different areas of Sardinia: the area around the town of...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Breeding units strategy; MtDNA haplogroup distribution; Association studies.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572011000200003
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The search for circadian clock components in humans: new perspectives for association studies 56
Allebrandt,K.V.; Roenneberg,T..
Individual circadian clocks entrain differently to environmental cycles (zeitgebers, e.g., light and darkness), earlier or later within the day, leading to different chronotypes. In human populations, the distribution of chronotypes forms a bell-shaped curve, with the extreme early and late types _ larks and owls, respectively _ at its ends. Human chronotype, which can be assessed by the timing of an individual's sleep-wake cycle, is partly influenced by genetic factors - known from animal experimentation. Here, we review population genetic studies which have used a questionnaire probing individual daily timing preference for associations with polymorphisms in clock genes. We discuss their inherent limitations and suggest an alternative approach combining...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Human clock genes; Chronotype; Morningness/eveningness; Association studies; Latitudinal hypothesis.
Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008000800013
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