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2-Styrylchromones as novel inhibitors of xanthine oxidase. A structure-activity study IPB - Escola Superior Agrária
Fernandes, Eduarda; Carvalho, Félix; Silva, Artur; Santos, Clementina M.M.; Pinto, Diana; Cavaleiro, José; Bastos, Maria de Lourdes.
The purpose of this study was the evaluation of the xanthine oxidase (XO) inhibition produced by some synthetic 2-styrylchromones. Ten polyhydroxylated derivatives with several substitution patterns were synthesised, and these and a positive control, allopurinol, were tested for their effects on XO activity by measuring the formation of uric acid from xanthine. The synthesised 2-styrylchromones inhibited xanthine oxidase in a concentration-dependent and non-competitive manner. Some IC50 values found were as low as 0.55mM, which, by comparison with the IC50 found for allopurinol (5.43 mM), indicates promising new inhibitors. Those 2-styrylchromones found to be potent XO inhibitors should be further evaluated as potential agents for the treatment of...
Tipo: Article Palavras-chave: 2-styrylchromones; Allopurinol; Benzopyrone; Xanthine oxidase inhibition.
Ano: 2002 URL: http://hdl.handle.net/10198/3931
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