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	Provedor de dados BJMBR (3) Genet. Mol. Biol. (3) Ciênc. Tecnol. Aliment. (1) BABT (1) Autor Abbas,Seher (1) Bibi,Nazia (1) Bishop,Mike (1) Chao-Hsiang,Chang (1) Chen,Gang (1) DONG,Zhen (1) Ding,Q. (1) Frier,Malcolm (1) Fuu-Jen,Tsai (1) Gu,C.G. (1) HUANG,Tao (1) He,Yunfeng (1) Hopper,Melanie (1) Hsi-Chin,Wu (1) Huey-Yi,Chen (1) Hussain,Alamdar (1) JI,Jianlei (1) Jiang,H. (1) Jing,Peng (1) Khan,Muhammad Jadoon (1) Mais... Palavra-chave Bladder cancer (8) Antibody (1) BIU-87 (1) Cell permeability (1) Drug vehicle (1) Gene expression (1) Gene silencing (1) HRAS (1) Hypoxia inducible factor-1α (1) Intravesical chemotherapy (1) Oncogene (1) PCR-RFLP (1) Proliferation (1) Protein phosphatase magnesium/manganese-dependent 1D (1) RNA interference (1) Radioimmunotherapy (1) SNARE (1) Single nucleotide polymorphism (1) Single-walled carbon nanotubes (1) THP (1) Mais... Tipo do documento Info:eu-repo/semantics/article (8) Ano 2020 (1) 2019 (1) 2018 (1) 2014 (1) 2012 (1) 2004 (2) 2002 (1) Mais... País Brazil (8) Idioma Inglês (8)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 8 Primeira ... 1 ... Última Antibody conjugate radioimmunotherapy of superficial bladder cancer BABT Perkins,Alan; Hopper,Melanie; Murray,Andrea; Frier,Malcolm; Bishop,Mike. The administration of antibody conjugates for cancer therapy is now proving to be of clinical value. We are currently undertaking a programme of clinical studies using the monoclonal antibody C595 (IgG3) which reacts with the MUC1 glycoprotein antigen that is aberrantly expressed in a high proportion of bladder tumours. Radioimmunoconjugates of the C595 antibody have been produced with high radiolabelling efficiency and immunoreactivity using Tc-99m and In-111 for diagnostic imaging, and disease staging and the cytotoxic radionuclides Cu-67 and Re-188 for therapy of superficial bladder cancer. A Phase I/II therapeutic trail involving the intravesical administration of antibody directly into the bladder has now begun. Tipo: Info:eu-repo/semantics/article Palavras-chave: Antibody; Radioimmunotherapy; Bladder cancer. Ano: 2002 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132002000500012 High frequency of the HRAS oncogene codon 12 mutation in Macedonian patients with urinary bladder cancer Genet. Mol. Biol. Panov,Sasho; Roganovic-Zafirova,Danica; Stavric,George; Yashar,Genghis; Popov,Zivko. Point mutations at codon 12 of the HRAS (v-Ha-ras Harvey rat sarcoma viral oncogene homolog) oncogene are one of the best defined and widely studied molecular genetic events in transitional cell carcinoma (TCC) of the urinary bladder. The aim of this study was to use the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis of paraffin-embedded tissue-derived DNA to determine the frequency of the HRAS oncogene G ->T codon 12 mutation in TCC patients being treated at the University Urology Clinic in Skopje, Republic of Macedonia. DNA isolated from paraffin-embedded tissue (PET) surgically removed TCC specimens of 62 (81.58%) out of 76 patients were successfully amplified, the remaining 14 (18.42%) showing compromised DNA... Tipo: Info:eu-repo/semantics/article Palavras-chave: HRAS; Oncogene; Bladder cancer; PCR-RFLP. Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572004000100002 In vitro and in vivo studies of pirarubicin-loaded SWNT for the treatment of bladder cancer BJMBR Chen,Gang; He,Yunfeng; Wu,Xiaohou; Zhang,Yao; Luo,Chunli; Jing,Peng. Intravesical chemotherapy is an important part of the treatment for superficial bladder cancer. However, the response to it is limited and its side effects are extensive. Functional single-walled carbon nanotubes (SWNT) have shown promise for tumor-targeted accumulation and low toxicity. In the present study, we performed in vivo and in vitro investigations to determine whether SWNT-based drug delivery could induce high tumor depression in rat bladder cancer and could decrease the side effects of pirarubicin (tetrahydropyranyl-adriamycin, THP). We modified SWNT with phospholipid-branched polyethylene glycol and constructed an SWNT-THP conjugate via a cleavable ester bond. The cytotoxicity of SWNT-THP against the human bladder cancer cell line BIU-87 was... Tipo: Info:eu-repo/semantics/article Palavras-chave: Single-walled carbon nanotubes; Bladder cancer; Drug vehicle; THP; Intravesical chemotherapy. Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000800012 Increased expression levels of Syntaxin 1A and Synaptobrevin 2/Vesicle-Associated Membrane Protein-2 are associated with the progression of bladder cancer Genet. Mol. Biol. Raja,Sadaf Azad; Abbas,Seher; Shah,Syed Tahir Abbas; Tariq,Aamira; Bibi,Nazia; Yousuf,Arzu; Khawaja,Athar; Nawaz,Muhammad; Mehmood,Arshad; Khan,Muhammad Jadoon; Hussain,Alamdar. Abstract Gene expression is tightly regulated in time and space through a multitude of factors consisting of signaling molecules. Soluble N-ethylmaleimide-sensitive-factor attachment protein receptors (SNARE) are membrane proteins responsible for the intercellular trafficking of signals through endocytosis and exocytosis of vesicles. Altered expression of SNARE proteins in cellular communication is the major hallmark of cancer phenotypes as indicated in recent studies. SNAREs play an important role in maintaining cell growth and epithelial membrane permeability of the bladder and are not only involved in cancer progression but also metastatic cell invasion through SNARE-mediated trafficking. Synaptobrevin2/Vesicle associated membrane protein-2 (v-SNARE)... Tipo: Info:eu-repo/semantics/article Palavras-chave: SNARE; Bladder cancer; Vesicle fusion; Gene expression. Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572019000100040 Inhibitory effects of tanshinone IIA from Salvia miltiorrhiza Bge on human bladder cancer BIU-87 cells and xenograft in nude mice Ciênc. Tecnol. Aliment. HUANG,Tao; YANG,Xiaokun; JI,Jianlei; WANG,Qinghai; WANG,Hongyang; DONG,Zhen. Abstract The objective of this study was to investigate the inhibitory effects of tanshinone IIA on human bladder cancer BIU-87 cells and the xenograft in nude mice. BIU-87 cells were treated with tanshinone IIA with concentration of 0.5, 1, 2 and 4 g/L. The cell proliferation, cycle and apoptosis were detected. The nude mice with BIU-87 cell xenograft were treated with normal saline (control), 5-fluorouracil (5-FU), 200, 400 and 600 mg/kg tanshinone IIA, respectively. The animal body weight and growth of tumor were measured. The expressions of B-cell lymphoma-2 (Bcl-2), Caspase-3 and proliferating cell nuclear antigen (PCNA) protein in xenograft were detected. The apoptosis index of cells was determined. Results showed that, tanshinone IIA inhibited the... Tipo: Info:eu-repo/semantics/article Palavras-chave: Bladder cancer; Tanshinone IIA; BIU-87; Xenograft. Ano: 2020 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612020000100209 Mechanism of hif-1α mediated hypoxia-induced permeability changes in bladder endothelial cells BJMBR Liu,C.; Shui,C.L.; Wang,Q.; Luo,H.; Gu,C.G.. This study aimed to investigate the mechanism of hypoxia-inducible factor-1 alpha (HIF-1α) mediated hypoxia-induced permeability changes in bladder endothelial cells. Models of in vitro hypoxic cell culture of bladder cancer, bladder cancer cells with low HIF-1α expression and HIF-1α RNA interference (RNAi) expression vector were established. Western blot and reverse transcription polymerase chain reaction (RT-PCR) were used to detect the expression of HIF-1α and vascular endothelial growth factor (VEGF) in each group. Bladder cell permeability was determined. Results showed that protein and mRNA expression of HIF-1α and VEGF at 3 and 12 h of hypoxia were significantly higher than normal control (P<0.05), and peaked at 12 h. HIF-1α and VEGF expression... Tipo: Info:eu-repo/semantics/article Palavras-chave: Bladder cancer; Hypoxia inducible factor-1α; VEGF; Cell permeability; YC-1. Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000200616 Targeting PPM1D by lentivirus-mediated RNA interference inhibits the tumorigenicity of bladder cancer cells BJMBR Wang,W.; Zhu,H.; Zhang,H.; Zhang,L.; Ding,Q.; Jiang,H.. Protein phosphatase magnesium/manganese-dependent 1D (PPM1D) is a p53-induced phosphatase that functions as a negative regulator of stress response pathways and has oncogenic properties. However, the functional role ofPPM1D in bladder cancer (BC) remains largely unknown. In the present study, lentivirus vectors carrying small hairpin RNA (shRNA) targeting PPM1D were used to explore the effects ofPPM1D knockdown on BC cell proliferation and tumorigenesis. shRNA-mediated knockdown of PPM1D significantly inhibited cell growth and colony forming ability in the BC cell lines 5637 and T24. Flow cytometric analysis showed that PPM1D silencing increased the proportion of cells in the G0/G1 phase. Downregulation of PPM1Dalso inhibited 5637 cell tumorigenicity in... Tipo: Info:eu-repo/semantics/article Palavras-chave: Protein phosphatase magnesium/manganese-dependent 1D; Bladder cancer; Gene silencing; RNA interference; Proliferation. Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2014001201044 Urokinase gene 3'-UTR T/C polymorphism is not associated with bladder cancer Genet. Mol. Biol. Hsi-Chin,Wu; Chao-Hsiang,Chang; Wen-Chi,Chen; Huey-Yi,Chen; Fuu-Jen,Tsai. Urokinase degrades basement proteins and is hypothesized to play a role in cancer progression. We investigated the hypothesis of C/T polymorphism in the 3'-untranslated region (3'-UTR) of the urokinase gene being associated with the development of bladder cancer. Such an association seems unlikely, since the genotype distributions in 114 bladder cancer patients did not differ from those of 105 controls. Tipo: Info:eu-repo/semantics/article Palavras-chave: Urokinase; Bladder cancer; Single nucleotide polymorphism. Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572004000100003 Registros recuperados: 8 Primeira ... 1 ... Última

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