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Altered heart rate and blood pressure variability in mice lacking the Mas protooncogene 56
Walther,T.; Wessel,N.; Kang,N.; Sander,A.; Tschöpe,C.; Malberg,H.; Bader,M.; Voss,A..
Heart rate variability is a relevant predictor of cardiovascular risk in humans. A significant genetic influence on heart rate variability is suggested, although the genes involved are ill-defined. The Mas-protooncogene encodes a G-protein-coupled receptor with seven transmembrane domains highly expressed in testis and brain. Since this receptor is supposed to interact with the signaling of angiotensin II, which is an important regulator of cardiovascular homeostasis, heart rate and blood pressure were analyzed in Mas-deficient mice. Using a femoral catheter the blood pressure of mice was measured for a period of 30 min and 250 data values per second were recorded. The mean values and range of heart rate and blood pressure were then calculated. Neither...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Blood pressure variability; Heart rate variability; Baroreflex sensitivity; Mas protooncogene.
Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000100001
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Pulmonary function, cholinergic bronchomotor tone, and cardiac autonomic abnormalities in type 2 diabetic patients 56
Melo,E.; Vianna,E.O.; Gallo Jr.,L.; Foss,M.C.; Terra-Filho,J..
This prospective study analyzed the involvement of the autonomic nervous system in pulmonary and cardiac function by evaluating cardiovascular reflex and its correlation with pulmonary function abnormalities of type 2 diabetic patients. Diabetic patients (N = 17) and healthy subjects (N = 17) were evaluated by 1) pulmonary function tests including spirometry, He-dilution method, N2 washout test, and specific airway conductance (SGaw) determined by plethysmography before and after aerosol administration of atropine sulfate, and 2) autonomic cardiovascular activity by the passive tilting test and the magnitude of respiratory sinus arrhythmia (RSA). Basal heart rate was higher in the diabetic group (87.8 ± 11.2 bpm; mean ± SD) than in the control group (72.9...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Diabetes mellitus; Autonomic nervous system; Autonomic neuropathy; Heart rate variability; Blood pressure variability.
Ano: 2003 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000300002
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Time course of changes in heart rate and blood pressure variability in rats with myocardial infarction 56
Aires,R.; Pimentel,E.B.; Forechi,L.; Dantas,E.M.; Mill,J.G..
Our aim was to determine the time course of changes in autonomic balance in the acute (1 and 3 days), sub-acute (7 days) and chronic (28 days) phases of myocardial infarction (MI) in rats. Autonomic balance was assessed by temporal and spectral analyses of blood pressure variability (BPV) and heart rate variability (HRV). Pulsatile blood pressure (BP) recordings (30 min) were obtained in awake and unrestrained male Wistar rats (N = 77; 8-10 weeks old) with MI (coronary ligature) or sham operation (SO). Data are reported as means±SE. The high frequency (HF) component (n.u.) of HRV was significantly lower in MI-1- (P<0.01) and MI-3-day rats (P<0.05) than in their time-control groups (SO-1=68±4 vs MI-1=35.3±4.3; SO-3=71±5.8 vs MI-3=45.2±3.8), without...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Myocardial infarction; Heart rate variability; Blood pressure variability; Autonomic nervous system; Heart failure.
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017000100605
Registros recuperados: 3
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