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Walther,T.; Wessel,N.; Kang,N.; Sander,A.; Tschöpe,C.; Malberg,H.; Bader,M.; Voss,A.. |
Heart rate variability is a relevant predictor of cardiovascular risk in humans. A significant genetic influence on heart rate variability is suggested, although the genes involved are ill-defined. The Mas-protooncogene encodes a G-protein-coupled receptor with seven transmembrane domains highly expressed in testis and brain. Since this receptor is supposed to interact with the signaling of angiotensin II, which is an important regulator of cardiovascular homeostasis, heart rate and blood pressure were analyzed in Mas-deficient mice. Using a femoral catheter the blood pressure of mice was measured for a period of 30 min and 250 data values per second were recorded. The mean values and range of heart rate and blood pressure were then calculated. Neither... |
Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Blood pressure variability; Heart rate variability; Baroreflex sensitivity; Mas protooncogene. |
Ano: 2000 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000100001 |
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