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Lack of effect of cell-wall targeted antibacterials on biofilm formation and antifungal susceptibility of Candidaspecies BJPS
Leite,Gisela Myrian de Lima; Baeza,Lílian Cristiane; Ramos,Rosana Teixeira; Yamada,Sérgio Seiji; Magon,Thiago Ferreira dos Santos; Kimura,Elza; Svidzinski,Terezinha Inez Estivalet.
The use of central venous catheters (CVC) and broad-spectrum antibacterials are among the main risk factors for the development of candidemia in patients admitted to intensive care units (ICU). It is known that some antibacterials increase the resistance of these yeasts to azole antifungals. Thus, the aim of this research was to determine whether yeast present in CVC colonizations previously exposed to cell-wall targeted antibacterials benefit from a reduction in susceptibility to fluconazole and voriconazole, facilitating their ability to form biofilms. Candida albicans, C. tropicalis, C. glabrata, C. parapsilosis and C. guilhermondii were seeded into antibacterial (cefepime, meropenem, vancomycin, and piperacillin-tazobactam) gradient plates produced in...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Central venous cateter/use; Candidemia/control; Biofilm/formation; Antibacterials; Antifungals; Candida/species/control.
Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000300467
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