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Ordenar por: RelevânciaAutorTítuloAnoImprime registros no formato resumido
Registros recuperados: 5
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Imprime registro no formato completo
Cardiopulmonary bypass alters the pharmacokinetics of propranolol in patients undergoing cardiac surgery BJMBR
Carmona,M.J.C.; Malbouisson,L.M.S.; Pereira,V.A.; Bertoline,M.A.; Omosako,C.E.K.; Le Bihan,K.B.; Auler Jr.,J.O.C.; Santos,S.R.C.J..
The pharmacokinetics of propranolol may be altered by hypothermic cardiopulmonary bypass (CPB), resulting in unpredictable postoperative hemodynamic responses to usual doses. The objective of the present study was to investigate the pharmacokinetics of propranolol in patients undergoing coronary artery bypass grafting (CABG) by CPB under moderate hypothermia. We evaluated 11 patients, 4 women and 7 men (mean age 57 ± 8 years, mean weight 75.4 ± 11.9 kg and mean body surface area 1.83 ± 0.19 m²), receiving propranolol before surgery (80-240 mg a day) and postoperatively (10 mg a day). Plasma propranolol levels were measured before and after CPB by high-performance liquid chromatography. Pharmacokinetic Solutions 2.0 software was used to estimate the...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Propranolol; Pharmacokinetics; Cardiopulmonary bypass.
Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000500008
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Clinical applications of retrograde autologous priming in cardiopulmonary bypass in pediatric cardiac surgery BJMBR
Fu,G.W.; Nie,Y.F.; Jiao,Z.Y.; Zhao,W.Z..
Retrograde autologous priming (RAP) has been routinely applied in cardiac pediatric cardiopulmonary bypass (CPB). However, this technique is performed in pediatric patients weighing more than 20 kg, and research about its application in pediatric patients weighing less than 20 kg is still scarce. This study explored the clinical application of RAP in CPB in pediatric patients undergoing cardiac surgery. Sixty pediatric patients scheduled for cardiac surgery were randomly divided into control and experimental groups. The experimental group was treated with CPB using RAP, while the control group was treated with conventional CPB (priming with suspended red blood cells, plasma and albumin). The hematocrit (Hct) and lactate (Lac) levels at different...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Cardiopulmonary bypass; Retrograde autologous priming; Cardiac surgery.
Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016000500703
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Computed tomography assessment of lung structure in patients undergoing cardiac surgery with cardiopulmonary bypass BJMBR
Rodrigues,R.R.; Sawada,A.Y.; Rouby,J.-J.; Fukuda,M.J.; Neves,F.H.; Carmona,M.J.; Pelosi,P.; Auler,J.O.; Malbouisson,L.M.S..
Hypoxemia is a frequent complication after coronary artery bypass graft (CABG) with cardiopulmonary bypass (CPB), usually attributed to atelectasis. Using computed tomography (CT), we investigated postoperative pulmonary alterations and their impact on blood oxygenation. Eighteen non-hypoxemic patients (15 men and 3 women) with normal cardiac function scheduled for CABG under CPB were studied. Hemodynamic measurements and blood samples were obtained before surgery, after intubation, after CPB, at admission to the intensive care unit, and 12, 24, and 48 h after surgery. Pre- and postoperative volumetric thoracic CT scans were acquired under apnea conditions after a spontaneous expiration. Data were analyzed by the paired Student t-test and one-way repeated...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Hypoxemia; Computed tomography; Coronary artery bypass graft; Cardiopulmonary bypass.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000600014
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Diclofenac plasma protein binding: PK-PD modelling in cardiac patients submitted to cardiopulmonary bypass BJMBR
Twenty-four surgical patients of both sexes without cardiac, hepatic, renal or endocrine dysfunctions were divided into two groups: 10 cardiac surgical patients submitted to myocardial revascularization and cardiopulmonary bypass (CPB), 3 females and 7 males aged 65 ± 11 years, 74 ± 16 kg body weight, 166 ± 9 cm height and 1.80 ± 0.21 m2 body surface area (BSA), and control, 14 surgical patients not submitted to CPB, 11 female and 3 males aged 41 ± 14 years, 66 ± 14 kg body weight, 159 ± 9 cm height and 1.65 ± 0.16 m2 BSA (mean ± SD). Sodium diclofenac (1 mg/kg, im Voltaren 75® twice a day) was administered to patients in the Recovery Unit 48 h after surgery. Venous blood samples were collected during a period of 0-12 h and analgesia was measured by the...
Palavras-chave: Diclofenac; Plasma protein binding; Cardiopulmonary bypass; Kinetic-dynamic parameters; Analgesia; Visual analogue scale.
Ano: 1997 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997000300010
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Effect of cardiopulmonary bypass on the pharmacokinetics of propranolol and atenolol BJMBR
Carmona,M.J.C.; Pereira,V.A.; Malbouisson,L.M.S.; Auler Jr.,J.O.C.; Santos,S.R.C.J..
The pharmacokinetics of some β-blockers are altered by cardiopulmonary bypass (CPB). The objective of this study was to compare the effect of coronary artery bypass graft (CABG) surgery employing CPB on the pharmacokinetics of propranolol and atenolol. We studied patients receiving oral propranolol with doses ranging from 80 to 240 mg (N = 11) or atenolol with doses ranging from 25 to 100 mg (N = 8) in the pre- and postoperative period of CABG with moderately hypothermic CPB (32°C). On the day before and on the first day after surgery, blood samples were collected before β-blocker administration and every 2 h thereafter. Plasma levels were determined using high-performance liquid chromatography and data were treated by pharmacokinetics-modelling....
Tipo: Info:eu-repo/semantics/article Palavras-chave: Propranolol; Atenolol; Pharmacokinetics; Coronary artery bypass grafting surgery; Cardiopulmonary bypass.
Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000600016
Registros recuperados: 5
Primeira ... 1 ... Última
 

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