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Registros recuperados: 28
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Association of Bartonella spp bacteremia with Chagas cardiomyopathy, endocarditis and arrythmias in patients from South America BJMBR
Corrêa,F.G.; Pontes,C.L.S.; Verzola,R.M.M.; Mateos,J.C.P.; Velho,P.E.N.F.; Schijman,A.G.; Selistre-de-Araujo,H.S..
Infection with Bartonella spp may cause cardiac arrhythmias, myocarditis and endocarditis in humans. The aim of the present study was to evaluate a possible association between Bartonella spp bacteremia and endocarditis, arrhythmia and Chagas cardiomyopathy in patients from Brazil and Argentina. We screened for the presence of bacterial 16S rRNA in human blood by PCR using oligonucleotides to amplify a 185-bp bacterial DNA fragment. Blood samples were taken from four groups of subjects in Brazil and Argentina: i) control patients without clinical disease, ii) patients with negative blood-culture endocarditis, iii) patients with arrhythmias, and iv) patients with chronic Chagas cardiomyopathy. PCR products were analyzed on 1.5% agarose gel to visualize the...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Human; PCR; Bartonella spp; Chagas disease; Endocarditis; Arrhythmia.
Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000700012
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Behavioral evidence of an ectoparasitic interaction between Triatoma pseudomaculata Corrêa e Espínola (Heteroptera: Reduviidae) and Periplaneta americana (L.) (Blattodea: Blattidae) Neotropical Entomology
Pontes,GB; Noireau,F; Lorenzo,MG.
The present work tested whether Triatoma pseudomaculata Corrêa & Espínola shows behavioral traits indicating that it is capable of feeding on arthropods. We consistently observed nymphs extending their proboscis in the direction of cockroaches and attempting to bite. Insects presented a preference for biting specific cockroach body parts. Our results suggest that arthropod hemolymph represents an alternative source of food that increases the survival of T. pseudomaculata individuals undergoing long starvation.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Behavior; Chagas disease; Cockroach; Triatomine.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1519-566X2011000600013
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Benznidazole affects expression of Th1, Th17 and Treg cytokines during acute experimental Trypanosoma cruzi infection J. Venom. Anim. Toxins incl. Trop. Dis.
Gatto,Mariana; Oliveira,Larissa Ragozo Cardoso; Dias,Fernanda De Nuzzi; Araújo Júnior,João Pessoa; Lima,Carlos Roberto Gonçalves; Lordelo,Eliana Peresi; Santos,Rodrigo Mattos dos; Kurokawa,Cilmery Suemi.
Abstract Background The present study evaluated the effect of treatment with benznidazole on mRNA expression of IFN-γ, IL-17, IL-10, TGF-β and FoxP3 in spleen and heart tissue of BALB/c mice in the acute phase of an experimental infection with Trypanosoma cruzi, strains JLP or Y. Methods The mRNA expression of cytokines and parasite load were assessed by q-PCR. Dependent groups were compared using Student's paired t-test and independent groups were compared using Student's unpaired t-test. Results Infection with the JLP or Y strains increased expression of IFN-γ in the heart and of IL-10 and IL-17 in the spleen and heart compared to uninfected animals. Treatment increased the expression of IFN-γ and decreased the expression of IL-17, IL-10, TGF- β and...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Chagas disease; Trypanosoma cruzi; Immune response; Cytokines; Q-PCR.
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992017000100320
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Candida Glabrata Esophagitis: new case reports and management BJM
Macêdo,Danielle Patrícia Cerqueira; Silva,Vanessa Karina Alves da; Farias,Aline Mary de Almeida; Melo,Luciana Resende Bandeira de; Wilheim,Ana Botler; Neves,Rejane Pereira.
Candida esophagitis (CE) is a common opportunistic infection in the immunocompromised host. C. glabrata is rarely cited as agent of CE and has been underestimated due to lack of proper identification. In this study, two cases of C. glabrata esophagitis in AIDS and chagasic patients are reported. Diagnosis of Candida species should be considered an important key for the ideal choice of antifungal therapy against this mycosis.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Candida glabrata; Esophagitis; AIDS; Chagas disease.
Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822008000200015
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Canine trypanosomiasis: etiology of infection and implications for public health J. Venom. Anim. Toxins incl. Trop. Dis.
Eloy,LJ; Lucheis,SB.
Canine trypanosomiasis, caused by protozoans of the genus Trypanosoma, is divided into two primary types: the American form (Chagas disease), due to Trypanosoma cruzi infection, and the African form (sleeping sickness or surra), provoked by Trypanosomaevansi. This disease was originally enzootic and affected only wild animals, including mammals and birds, which served as reservoirs. Later, it spread to domestic animals such as horses, cattle and dogs. The disease became a zoonosis when contact between rural inhabitants and natural Trypanosoma foci occurred, due to ecological imbalances and increasing migration. Dogs are significantly involved in this context, because they are the main domestic animals and participate in the transmission and maintenance...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Canine trypanosomiasis; Trypanosoma cruzi; Trypanosoma evansi; Chagas disease; Surra.
Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992009000400002
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Chagas disease in prehistory Anais da ABC (AABC)
Ferreira,Luiz F.; Jansen,Ana M.; Araújo,Adauto.
The classical hypothesis proposes that Chagas disease has been originated in the Andean region among prehistoric people when they started domesticating animals, changing to sedentary habits, and adopting agriculture. These changes in their way of life happened nearly 6,000 years ago. However, paleoparasitological data based on molecular tools showed that Trypanosoma cruzi infection and Chagas disease were commonly found both in South and North American prehistoric populations long before that time, suggesting that Chagas disease may be as old as the human presence in the American continent. The study of the origin and dispersion of Trypanosoma cruzi infection among prehistoric human populations may help in the comprehension of the clinical and...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Ancient DNA; Chagas disease; Mummies; Paleoepideiology; Paleoparasitology; Trypanosoma cruzi.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652011000300022
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Chagas disease: Present status of pathogenic mechanisms and chemotherapy Biol. Res.
Maya,Juan Diego; Orellana,Myriam; Ferreira,Jorge; Kemmerling,Ulrike; López-Muñoz,Rodrigo; Morello,Antonio.
There are approximately 7.8 million people in Latin America, including Chile, who suffer from Chagas disease and another 28 million who are at risk of contracting it. Chagas is caused by the flagellate protozoan Trypanosoma cruzi. It is a chronic disease, where 20%-30% of infected individuals develop severe cardiopathy, with heart failure and potentially fatal arrhythmias. Currently, Chagas disease treatment is more effective in the acute phase, but does not always produce complete parasite eradication during indeterminate and chronic phases. At present, only nifurtimox or benznidazole have been proven to be superior to new drugs being tested. Therefore, it is necessary to find alternative approaches to treatment of chronic Chagas. The current treatment...
Tipo: Journal article Palavras-chave: Chagas disease; Chemotherapy; Nifurtimox; Trypanosoma cruzi; Prostaglandins.
Ano: 2010 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602010000300009
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Clinical and nutritional profile of individuals with chagas disease BJID
Geraix,Juliana; Ardisson,Lidiane Paula; Marcondes-Machado,Jussara; Pereira,Paulo Câmara Marques.
Chagas disease (CD), caused by the protozoan Trypanossoma cruzi, affects approximately 18 million individuals in the Americas, 5 million of which live in Brazil. Most chronic sufferers have either the indeterminate form of the disease, without organic compromise, or the cardiac or digestive forms. Despite the importance of this disease, there is no information on the effect of nutrition on CD evolution. We evaluated the clinical-nutritional profile of individuals with CD treated at the Tropical Diseases Nutrition Out-Patient Clinic of the Botucatu School of Medicine, UNESP. A retrospective cohort study was performed between 2002 and 2006, on 66 patients with serum and parasitological diagnosis of CD. Epidemiological, clinical, nutritional, and biochemical...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Chagas disease; Nutrition; Dyslipidemia.
Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000400008
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Co-infection and wild animal health: effects of Trypanosomatids and gastrointestinal parasites on coatis of the Brazilian Pantanal. Repositório Alice
OLIFIERS N.; JANSEN A. M.; HERRERA H. M.; BIANCHI, R. de C.; D'ANDREA P. S.; MOURAO, G..
Wild animals are infected by diverse parasites, but how they influence host health is poorly understood. We examined the relationship of trypanosomatids and gastrointestinal parasites with health of wild brown-nosed coatis (Nasua nasua) from the Brazilian Pantanal. We used coati body condition and hematological parameters as response variables in linear models that were compared using an information theoretic approach. Predictors were high/low parasitemias by Trypanosoma cruzi and T. evansi, and indices representing the abundance of distinct groups of gastrointestinal parasites. We also analyzed how host health changed with host sex and reproductive seasonality. Hemoparasites was best related to coati body condition and hematological indices, whereas...
Tipo: Artigo em periódico indexado (ALICE) Palavras-chave: Quatis; Quati; Vetor; Chagas disease; Disease vectors.
Ano: 2015 URL: http://www.alice.cnptia.embrapa.br/handle/doc/1032991
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Control of Triatoma infestans (Klug) (Reduviidae: Triatominae) with Beauveria bassiana (Bals.) Vuill.: preliminary assays on formulation and application in the field Anais da SEB
Luz,Christian; Silva,Ionizete G.; Magalhães,Bonifácio P.; Cordeiro,Celia M. T.; Tigano,Myrian S..
Beauveria bassiana (Bals.) Vuill., isolate CG 306, was assayed against Triatoma infestans (Klug) using indirect application by contact with a treated filter paper. The fungus was deposited on filter paper by vacuum-filtration of a conidial suspension. Estimates of 50% survival time of insects were between 15 and 21 days at 3x10(6) and 10(7) conidia/cm² of treated support, respectively, without significant difference between concentrations. A concentration of 2.4x10(6) conidia/cm² of CG 306 was necessary to kill 50% of T. infestans third instar nymphs 25 days after inoculation at 25°C and 50% relative humidity, when insects were continuously exposed to conidia. The LC50 was significantly higher (2.0x10(7) conidia/cm²) when insects were exposed for 1 h to...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Insecta; Chagas disease; Biological control; Hyphomycetes.
Ano: 1999 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0301-80591999000100011
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Cysteine proteinases of Trypanosoma cruzi: from digestive enzymes to programmed cell death Biocell
Kosec,Gregor; Alvarez,Vanina; Cazzulo,Juan J..
Trypanosoma cruzi, the parasite causing Chagas disease, contains a number of proteolytic enzymes. The recent completion of the genome sequence of the T. cruzi CL Brener clone suggests the presence of 70 cysteine peptidases, 40 serine peptidases (none of them from the chymotrypsin family), about 250 metallopeptidases (most leishmanolysin homologues), 25 threonine peptidases, and only two aspartyl peptidases, none of them from the pepsin family. The cysteine peptidases belong to 7 families of Clan CA, 3 families of Clan CD, and one each of Clans CE and CF. In Clan CA, the C1 family is represented by cruzipains 1 and 2, biochemically well characterized, as well as cathepsin B and two other cathepsins. There are a number of homologues to calpains (family C2),...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Trypanosoma cruzi; Chagas disease; Cysteine proteinases; Apoptosis; Autophagy.
Ano: 2006 URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0327-95452006000300008
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Description and ontogenetic morphometrics of nymphs of Belminus herreri Lent & Wygodzinsky (Hemiptera: Reduviidae, Triatominae) Neotropical Entomology
Rocha,Dayse da S.; Patterson,James S.; Sandoval,Claudia M.; Jurberg,José; Ângulo,Victor M.; Esteban A.,Lyda; Galvão,Cleber.
For the first time all instars of a species of the genus Belminus are described based on laboratory F1 generation specimens from adults caught in department of Cesar, Colombia. Ontogenetic morphometrics of postembryonic head development was made, suggesting that the greatest changes occur between the 1st and 2nd instars.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Chagas disease; Vector; Bolboderini; Systematics.
Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1519-566X2005000300019
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Emerging acute Chagas Disease in Amazonian Brazil: case reports with serious cardiac involvement BJID
Pinto,Ana Yecê das Neves; Valente,Sebastião Aldo da Silva; Valente,Vera da Costa.
Four cases of serious cardiac attacks by autochthonous Trypanosoma cruzi infection from the Brazilian Amazon are reported; three of them occurred in micro-epidemic episodes. The manifestations included sudden fever, myalgia, dyspnea and signs of heart failure. Diagnosis was confirmed by specific exams, especially QBC (Quantitative Buffy Coat) and natural xenodiagnosis. Despite treatment with benznidazol, three patients died with serious myocarditis, renal failure and cardiac tamponade. The authors call attention to the emergence of this disease and reveal a previously unknown pathogenicity of T. cruzi strains in this area, added to a non-usual transmission form.
Tipo: Info:eu-repo/semantics/report Palavras-chave: Chagas disease; Trypanosomiasis; Cardiovascular; Brazilian Amazon; Myocarditis.
Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702004000600010
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In vitro activity of hypnophilin from Lentinus strigosus: a potential prototype for Chagas disease and leishmaniasis chemotherapy BJMBR
Souza-Fagundes,E.M.; Cota,B.B.; Rosa,L.H.; Romanha,A.J.; Corrêa-Oliveira,R.; Rosa,C.A.; Zani,C.L.; Teixeira-Carvalho,A.; Martins-Filho,O.A..
Hypnophilin and panepoxydone, terpenoids isolated from Lentinus strigosus, have significant inhibitory activity onTrypanosoma cruzi trypanothione reductase (TR). Although they have similar TR inhibitory activity at 10 μg/mL (40.3 μM and 47.6 μM for hypnophilin and panepoxydone, respectively; ~100%), hypnophilin has a slightly greater inhibitory activity (~71%) on T. cruzi amastigote (AMA) growth in vitro as well as on in vitro phytohemagglutinin (PHA)-induced peripheral blood mononuclear (PBMC) proliferation (~70%) compared to panepoxydone (69% AMA inhibition and 91% PBMC inhibition). Hypnophilin and panepoxydone at 1.25 μg/mL had 67% inhibitory activity onLeishmania (Leishmania) amazonensis amastigote-like (AMA-like) growth in vitro. The panepoxydone...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Chagas disease; Leishmaniasis; Chemotherapy; Immunomodulation; Hypnophilin; Lentinus strigosus.
Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010001100007
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Incidence of Trypanosoma cruzi transmission through breastfeeding during acute experimental Chagas disease BJID
Martins,Luciamare Perinetti Alves; Castanho,Roberto Esteves Pires; Nogueira,Adriano Barbosa; Silva,Otavio Turolo da; Gusmão,Alex Silva de.
OBJECTIVE: To verify the incidence of T. cruzi transmission through breastfeeding during acute experimental Chagas' disease. METHODS: Fifteen female Swiss mice were mated and, after pregnancy confirmation, placed in individual cages. A few hours after birth, the females were inoculated with 0.1 mL of blood containing approximately 3 x 10(5) trypomastigote forms of Y strain of T. cruzi and continued breastfeeding for 25 days. RESULTS: In 142 offspring examined no infection through breast-feeding was observed. CONCLUSIONS: The low number of trypomastigote forms ingested by the newborn mice combined with biological and biochemical characteristics of blood trypomastigotes may explain the lack of transmission in this experiment.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Trypanosoma cruzi; Foods for pregnant and breastfeeding mothers; Chagas disease.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000200004
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Indicadores de infestación, colonización e infección de Triatoma dimidiata (Latreille) (Hemiptera: Reduviidae) en Campeche, México Neotropical Entomology
Hernández,Jorge L; Rebollar-Téllez,Eduardo A; Infante,Francisco; Morón,Alejandro; Castillo,Alfredo.
Triatoma dimidiata (Latreille) is considered to be one of the primary vectors of Chagas disease in Southern Mexico and Central America. The objective of the present study was to obtain ecological information on T. dimidiata in two rural communities of Campeche, Mexico, where the vector is poorly studied. Our work consisted of monthly samplings carried out during one-year time at three levels: sylvatic, peridomestic and intradomestic, in order to estimate the population abundance of this species and its rate of infection with Trypanosoma cruzi. Triatoma dimidiata was the unique vector of this disease collected in San Juan Bautista Sakcabchen (SJBS) and Crucero San Luis (CSL). The total of 145 individuals were captured in SJBS; from these, 26.9%, 20% and...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Chagas disease; Triatominae; Entomological index; Population abundance.
Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1519-566X2010000600027
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Lethal effects of a Mexican Beauveria bassiana (Balsamo) strain against Meccus pallidipennis (Stal) BJM
Lino,Zumaquero Rios José; Juventino,López-Tlacomulco José; Raúl,Rojas García; Estibaliz,Sansinenea.
The entomopathogenic fungus Beauveria bassiana (Balsamo 1835) Vuillemin is an effective alternative control agent against some agricultural pests and biological vectors of important diseases such as Chagas disease. In this work we studied an isolate of Beauveria bassiana from of the town of San Antonio Rayón, Puebla, Mexico and its entomopathogenic effects on Meccus pallidipennis (Stal 1872). Phylogenetic analysis using molecular comparison of the ITS and EF1α genes, showed that the resulting cladogram places the BUAP 04 strain with a relationship closer to the AFAO 9-6 strain, within the diversity of the B. bassiana sensu lato group. Although there was the possibility that BUAP 04 strain was a direct descendant of strains used in campaigns of biologic...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Chagas disease; Biocontrol agent; Triatomines.
Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822014000200025
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Molecular research and the control of Chagas disease vectors Anais da ABC (AABC)
Abad-Franch,Fernando; Monteiro,Fernando A..
Chagas disease control initiatives are yielding promising results. Molecular research has helped successful programs by identifying and characterizing introduced vector populations and by defining intervention targets accurately. However, researchers and health officials are facing new challenges throughout Latin America. Native vectors persistently reinfest insecticide-treated households, and sylvatic triatomines maintain disease transmission in humid forest regions (including Amazonia) without colonizing human dwellings. In these scenarios, fine-scale vector studies are essential to define epidemiological risk patterns and clarify the involvement of little-known triatomine taxa in disease transmission. These eco-epidemiological investigations, as well as...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Molecular systematics; DNA; Allozymes; Triatominae; Chagas disease.
Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652005000300007
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Neuronal changes caused by Trypanosoma cruzi: an experimental model Anais da ABC (AABC)
Moreira,Neide M; Sant'ana,Débora M. G; Araújo,Eduardo J. A; Toledo,Max J. O; Gomes,Mônica L; Araújo,Silvana M. de.
Define an experimental model by evaluating quantitative and morphometric changes in myenteric neurons of the colon of mice infected with Trypanosoma cruzi. Twenty-eight Swiss male mice were distributed into groups: control (CG, n=9) and inoculated with 100 (IG100, n=9) and 1000 (IG1000, n=10) blood trypomastigotes, Y strain-T. cruzi II. Parasitemia was evaluated from 3-25 days post inoculation (dpi) with parasites peak of 7.7 × 10(6) and 8.4 × 10(6) trypomastigotes/mL at 8th dpi (p>0.05) in IG100 and IG1000, respectively. Chronic phase of the infection was obtained with two doses of 100mg/Kg/weight and one dose of 250mg/Kg/weight of Benznidazole on 11, 16 and 18 dpi. Three animals from each group were euthanized at 18, 30 and 75 dpi. The colon was...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Chagas disease; Colon; Enteric nervous system; Giemsa; Trypanosoma cruzi.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652011000200014
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Parameters for evaluation of clinical trial in mice infected with Trypanosoma cruzi Arq. Bras. Med. Vet. Zootec.
Falkowski,G.J.S.; Sandri,P.F.; Tiyo,R.; Aleixo,D.L.; Araújo,S.M..
The effectiveness of clinical parameters in the evaluation of Trypanosoma cruzi infection was analyzed in male Swiss mice at 8 weeks old Animals were divided into HG (healthy) and IG (1400 trypomastigotes, intraperitoneally, Y strain - Trypanosoma cruzi). Quantitative and qualitative parameters were evaluated in non-consecutive days in the period, from 7th-11th and 15th-18th days of infection. There were significant differences (P<0.05) between both groups in both periods regarding water consumption, abdominal circumference and weight. The second group presented differences in amount of excreta, body temperature, move-up and mortality. There was no difference (P&gt;0.05) between the groups in food consumption, exploration of self-cleaning and skin...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Clinical analysis; Chagas disease; Experimental infection; Mice; Trypanosoma cruzi.
Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352012000600020
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