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Registros recuperados: 25
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Breathing disorders in congestive heart failure: gender, etiology and mortality BJMBR
Silva,R.S.; Figueiredo,A.C.; Mady,C.; Lorenzi-Filho,G..
We investigated the relationship between sleep-disordered breathing (SDB) and Cheyne-Stokes respiration (CSR) while awake as well as mortality. Eighty-nine consecutive outpatients (29 females) with congestive heart failure (CHF; left ventricular ejection fraction, LVEF <45%) were prospectively evaluated. The presence of SDB and of CSR while awake before sleep onset was investigated by polysomnography. SDB prevalence was 81 and 56%, using apnea-hypopnea index cutoffs >5 and >15, respectively. CHF etiologies were similar according to the prevalence of SDB and sleep pattern. Males and females were similar in age, body mass index, and LVEF. Males presented more SDB (P = 0.01), higher apnea-hypopnea index (P = 0.04), more light sleep (stages 1 and 2; P...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Sleep apnea; Cheyne-Stokes respiration; Congestive heart failure; Gender; Chagas' disease.
Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008000300007
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Chagas' disease and Duffy antigen/receptor for chemokine (DARC): a mini-review J. Venom. Anim. Toxins incl. Trop. Dis.
Oliveira,AP; Mattos,LC; Cavasini,CE.
Duffy gene (FY) codifies the transmembrane glycoprotein Duffy (gp-Fy) of 35 to 43 kDa which is moderately immunogenic. This glycoprotein is polymorphic, and constitutes the antigens of the Duffy histo-blood system which were designated receptors for chemokines and denominated DARC (Duffy antigen/receptor for chemokine). This receptor has an important role in the regulation of chemokine levels in the circulation, as it binds and adsorbs them on the surface of red cells as a reservoir. It plays a "sink" role, which can contribute to homeostasis by removing inflammatory chemokines from circulation as well as maintaining them in plasmatic levels. Chronic Chagas' cardiopathy (CCC) is the most frequent form of the disease. It is an inflammatory disease, in which...
Tipo: Info:eu-repo/semantics/article Palavras-chave: DARC antigen; Duffy blood-group system; Chagas' disease; Chagas' cardiomyopathy.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992011000300005
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Conventional serological performance in diagnosis of Chagas' disease in southern Brazil BJID
Araújo,Anelise Bergmann; Berne,Maria Elisabeth Aires.
Results of Chagas' disease diagnosis show disagreement. The aim of this study was to compare commercial tests for Chagas' disease serodiagnosis in southern Brazil. A total of 161 samples were evaluated. Three enzyme-linked immunosorbent assays, one indirect hemagglutination and one indirect immunofluorescence were assessed. Trypomastigote excreted-secreted antigen-blot was a confirmatory method. From 161 samples, 65.84% were positive in all tests, while 34.16% presents mismatch result in at least one of the tests. All techniques tested presented false-positive and/or false-negative results as follows: Enzyme-linked immunosorbent assay 1 had more false-positive results (lower specificity), indirect immunofluorescence had the highest rate of false-negative...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Trypanosoma cruzi; Chagas' disease; Serodiagnosis; Immunoassays.
Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000200010
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Effect of tranquilization and anesthesia on high-resolution electrocardiographic indices of dogs in the chronic chagasic myocardiopathy Arq. Bras. Med. Vet. Zootec.
Ferreira,W.L.; Paula,D.P.; Nunes,N.; Camacho,A.A..
The effect of tranquilization and anesthesia on high-resolution electrocardiography (HRECG) indices of dogs in the undetermined chronic phase of Chagas' disease was studied. Eight adult female mongrel dogs were submitted to six protocols: group 1: animals not submitted to tranquilization or anesthesia; group 2: tranquilization with acepromazine; group 3: tranquilization with a combination of acepromazine and buprenorphine; group 4: general inhalatory anesthesia with isoflurane; group 5: general inhalatory anesthesia with sevoflurane; group 6: anesthesia with propofol. The animals were submitted to all protocols at an interval of 15 days between assessments. HRECG was performed in the time domain. Regarding the electrocardiographic parameters analyzed, no...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Dog; Chagas' disease; High-resolution electrocardiography; Anesthesia.
Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352006000600015
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Esophageal striated muscle contractions in patients with Chagas' disease and idiopathic achalasia BJMBR
Dantas,R.O.; Aprile,L.R.O.; Aben-Athar,C.G.; Miranda,A.L.M..
Chagas' disease causes degeneration and reduction of the number of intrinsic neurons of the esophageal myenteric plexus, with consequent absent or partial lower esophageal sphincter relaxation and loss of peristalsis in the esophageal body. The impairment of esophageal motility is seen mainly in the distal smooth muscle region. There is no study about esophageal striated muscle contractions in the disease. In 81 patients with heartburn (44 with esophagitis) taken as controls, 51 patients with Chagas' disease (21 with esophageal dilatation) and 18 patients with idiopathic achalasia (11 with esophageal dilatation) we studied the amplitude, duration and area under the curve of esophageal proximal contractions. Using the manometric method and a continuous...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Esophageal contractions; Chagas' disease; Idiopathic achalasia; Esophageal striated muscle.
Ano: 2002 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000600007
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Evolution of hematophagous habit in Triatominae (Heteroptera: Reduviidae) RChHN
Otálora-Luna,Fernando; Pérez-Sánchez,Antonio J; Sandoval,Claudia; Aldana,Elis.
All members of Triatominae subfamily (Heteroptera: Reduviidae), potential vectors of Trypanosoma cruzi etiologic agent of the Chagas disease, feed on blood. Through evolution, these bugs have fixed special morphological, physiological, and behavioral aptations (adaptations and exaptations) adequate to feed on blood. Phylogeny suggests that triatomines evolved from predator reduvids which in turn descended from phytophagous hemipterans. Some pleisiomorphic traits developed by the reduvid ancestors of the triatomines facilitated and modeled hematophagy in these insects. Among them, mouthparts, saliva composition, enzymes, and digestive symbionts are the most noticeable. However, the decisive step that allowed the shift from predation to hematophagy was a...
Tipo: Journal article Palavras-chave: Latin America; Chagas' disease; Phylogeny; Blood-sucking habit; Triatomines.
Ano: 2015 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-078X2015000100004
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Immunodominance: a new hypothesis to explain parasite escape and host/parasite equilibrium leading to the chronic phase of Chagas' disease? BJMBR
Rodrigues,M.M.; Alencar,B.C.G. de; Claser,C.; Tzelepis,F..
Intense immune responses are observed during human or experimental infection with the digenetic protozoan parasite Trypanosoma cruzi. The reasons why such immune responses are unable to completely eliminate the parasites are unknown. The survival of the parasite leads to a parasite-host equilibrium found during the chronic phase of chagasic infection in most individuals. Parasite persistence is recognized as the most likely cause of the chagasic chronic pathologies. Therefore, a key question in Chagas' disease is to understand how this equilibrium is established and maintained for a long period. Understanding the basis for this equilibrium may lead to new approaches to interventions that could help millions of individuals at risk for infection or who are...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Chagas' disease; Trypanosoma cruzi; Immunodominance; Major histocompatibility complex.
Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000300001
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Induction of chagasic-like arrhythmias in the isolated beating hearts of healthy rats perfused with Trypanosoma cruzi-conditioned medium BJMBR
Rodríguez-Angulo,H.; Toro-Mendoza,J.; Marques,J.; Bonfante-Cabarcas,R.; Mijares,A..
Chagas' myocardiopathy, caused by the intracellular protozoan Trypanosoma cruzi, is characterized by microvascular alterations, heart failure and arrhythmias. Ischemia and arrythmogenesis have been attributed to proteins shed by the parasite, although this has not been fully demonstrated. The aim of the present investigation was to study the effect of substances shed by T. cruzi on ischemia/reperfusion-induced arrhythmias. We performed a triple ischemia-reperfusion (I/R) protocol whereby the isolated beating rat hearts were perfused with either Vero-control or Vero T. cruzi-infected conditioned medium during the different stages of ischemia and subsequently reperfused with Tyrode's solution. ECG and heart rate were recorded during the entire experiment. We...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Chagas' disease; Arrhythmias; Ischemia.
Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013000100058
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Inositol metabolism in Trypanosoma cruzi: potential target for chemotherapy against Chagas' disease Anais da ABC (AABC)
OLIVEIRA,MECIA M.; EINICKER-LAMAS,MARCELO.
Chagas' disease is a debilitating and often fatal disease caused by the protozoan parasite Trypanosoma cruzi. The great majority of surface molecules in trypanosomes are either inositol-containing phospholipids or glycoproteins that are anchored into the plasma membrane by glycosylphosphatidylinositol anchors. The polyalcohol myo-inositol is the precursor for the biosynthesis of these molecules. In this brief review, recent findings on some aspects of the molecular and cellular fate of inositol in T. cruzi life cycle are discussed and identified some points that could be targets for the development of parasite-specific therapeutic agents.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Inositol; Trypanosoma cruzi; Chagas' disease; Chemotherapy.
Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652000000300015
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Leishmania infantum heat shock protein 83 for the serodiagnosis of tegumentary leishmaniasis BJMBR
Celeste,B.J.; Angel,S.O.; Castro,L.G.M.; Gidlund,M.; Goto,H..
The serologic assay is an important tool in the diagnosis of leishmaniasis. One of the most commonly used tests is enzyme-linked immunosorbent assay (ELISA). Since total Leishmania promastigotes are used as antigen in the routine assay, false-positive reactions are frequent due to cross-reaction with sera from other diseases, mainly Chagas' disease. Therefore, an antigen that determines less cross-reactivity has been pursued for the serodiagnosis of leishmaniasis. In the present study we analyzed the use of recombinant Leishmania infantum heat shock protein (Hsp) 83 in ELISA for the serodiagnosis of cutaneous (N = 12) and mucocutaneous leishmaniasis (N = 14) and we observed the presence of anti-L. infantum Hsp 83 antibodies in all samples as well as...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Leishmania infantum; Sp 83; ELISA; Serodiagnosis; Tegumentary leishmaniasis; Chagas' disease.
Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004001100001
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Leptin levels in different forms of Chagas' disease BJMBR
Fernandes,F.; Dantas,S.; Ianni,B.M.; Ramires,F.J.A.; Buck,P.; Salemi,V.M.C.; Lopes,H.F.; Mady,C..
Leptin is produced primarily by adipocytes. Although originally associated with the central regulation of satiety and energy metabolism, increasing evidence indicates that leptin may be an important mediator in cardiovascular pathophysiology. The aim of the present study was to investigate plasma leptin levels in patient with Chagas' heart disease and their relation to different forms of the disease. We studied 52 chagasic patients and 30 controls matched for age and body mass index. All subjects underwent anthropometric, leptin and N-terminal pro-brain natriuretic peptide (NT-proBNP) measurements and were evaluated by echocardiography, 12-lead electrocardiogram (ECG), and chest X-ray. All patients had fasting blood samples taken between 8:00 and 9:00 am....
Tipo: Info:eu-repo/semantics/article Palavras-chave: Chagas' disease; Leptin; Heart failure; Left ventricular failure.
Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007001200006
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Mechanical cardiac remodeling and new-onset atrial fibrillation in long-term follow-up of subjects with chronic Chagas' disease BJMBR
Benchimol-Barbosa,P.R.; Barbosa-Filho,J..
Atrial fibrillation (AF) affects subjects with Chagas' disease and is an indicator of poor prognosis. We investigated clinical, echocardiographic and electrocardiographic variables of Chagas' disease in a long-term longitudinal study as predictors of a new-onset AF episode lasting >24 h, nonfatal embolic stroke and cardiac death. Fifty adult outpatients (34 to 74 years old, 62% females) staged according to the Los Andes classification were enrolled. During a follow-up of (mean ± SD) 84.2 ± 39.0 months, 9 subjects developed AF (incidence: 3.3 ± 1.0%/year), 5 had nonfatal stroke (incidence: 1.3 ± 1.0%/year), and nine died (mortality rate: 2.3 ± 0.8%/year). The progression rate of left ventricular mass and left ventricular ejection fraction was...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Chagas' disease; Cardiomyopathy; Atrial fibrillation; Cardiac death; Embolic stroke; Prognosis.
Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000300006
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Minor segmental wall motion abnormalities detected in patients with Chagas' disease have adverse prognostic implications BJMBR
Pazin-Filho,A.; Romano,M.M.D.; Almeida-Filho,O.C.; Furuta,M.S.; Viviani,L.F.; Schmidt,A.; Marin-Neto,J.A.; Maciel,B.C..
Recent data from our laboratory have shown that patients with the indeterminate form of Chagas' disease can have impairment of left ventricular contractility, as evaluated by the slope of the left ventricle end-systolic pressure-dimension relationship. We also showed that Chagas' disease patients with minimal baseline wall motion abnormalities detected by two-dimensional echocardiography have more intense contractility impairment when compared to patients with the indeterminate form of the disease without this abnormality. The prognostic implications of these findings have not been established. We evaluated 59 patients (37-76 years, mean = 55 years) with different clinical forms of Chagas' disease, who had normal left ventricular global systolic function...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Echocardiography; Chagas' disease; Left ventricular function; Indeterminate form of Chagas' disease.
Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006000400008
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Molecular mimicry between cardiac myosin and Trypanosoma cruzi antigen B13: identification of a B13-driven human T cell clone that recognizes cardiac myosin BJMBR
Abel,L.C.J.; Kalil,J.; Cunha-Neto,E..
Previous reports from our group have demonstrated the association of molecular mimicry between cardiac myosin and the immunodominant Trypanosoma cruzi protein B13 with chronic Chagas' disease cardiomyopathy at both the antibody and heart-infiltrating T cell level. At the peripheral blood level, we observed no difference in primary proliferative responses to T. cruzi B13 protein between chronic Chagas' cardiopathy patients, asymptomatic chagasics and normal individuals. In the present study, we investigated whether T cells sensitized by T. cruzi B13 protein respond to cardiac myosin. T cell clones generated from a B13-stimulated T cell line obtained from peripheral blood of a B13-responsive normal donor were tested for proliferation against B13 protein and...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Molecular mimicry; Crossreactive T cells; Cardiac myosin; Trypanosoma cruzi; Chagas' disease.
Ano: 1997 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997001100007
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Noninvasive prognostic markers for cardiac death and ventricular arrhythmia in long-term follow-up of subjects with chronic Chagas' disease BJMBR
Benchimol-Barbosa,P.R..
The objective of the present study was to investigate clinical, echocardiographic and electrocardiographic (12-lead resting ECG, 24-h ambulatory ECG monitoring and signal-averaged ECG (SAECG)) parameters in subjects with chronic Chagas' disease in a long-term follow-up as prognostic markers for adverse outcomes. Fifty adult outpatients (34 to 74 years old, 31 females) staged according to Los Andes class I, II or III and complaining of palpitation were enrolled in a longitudinal study. SAECG was analyzed in time and frequency domains and the endpoint was a composite of cardiac death and ventricular tachycardia. During a follow-up of 84.2 ± 39.0 months, 34.0% of the patients developed adverse outcomes (9 cardiac deaths and 11 episodes of ventricular...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Chagas' disease; Cardiomyopathy; Noninvasive prognostic assessment; Long-term follow-up study; Echocardiography; Electrocardiography.
Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000200003
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Presence of autoantibodies against HeLa small nuclear ribonucleoproteins in chagasic and non-chagasic cardiac patients BJMBR
Bosetto,M.C.; Peixoto,M.S.; Castro,L.I.R. de; Cicarelli,R.M.B..
We detected anti-human small nuclear ribonucleoprotein (snRNP) autoantibodies in chagasic patients by different immunological methods using HeLa snRNPs. ELISA with Trypanosoma cruzi total lysate antigen or HeLa human U small nuclear ribonucleoproteins (UsnRNPs) followed by incubation with sera from chronic chagasic and non-chagasic cardiac patients was used to screen and compare serum reactivity. Western blot analysis using a T. cruzi total cell extract was also performed in order to select some sera for Western blot and immunoprecipitation assays with HeLa nuclear extract. ELISA showed that 73 and 95% of chronic chagasic sera reacted with HeLa UsnRNPs and T. cruzi antigens, respectively. The Western blot assay demonstrated that non-chagasic cardiac sera...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Chagas' disease; Autoantibodies; Small nuclear ribonucleoprotein; Trypanosoma cruzi; HeLa cells; Cross-reactivity.
Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000100006
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Protein 3-nitrotyrosine formation during Trypanosoma cruzi infection in mice BJMBR
Naviliat,M.; Gualco,G.; Cayota,A.; Radi,R..
Nitric oxide (·NO) is a diffusible messenger implicated in Trypanosoma cruzi resistance. Excess production of ·NO and oxidants leads to the generation of nitrogen dioxide (·NO2), a strong nitrating agent. Tyrosine nitration is a post-translational modification resulting from the addition of a nitro (-NO2) group to the ortho-position of tyrosine residues. Detection of protein 3-nitrotyrosine is regarded as a marker of nitro-oxidative stress and is observed in inflammatory processes. The formation and role of nitrating species in the control and myocardiopathy of T. cruzi infection remain to be studied. We investigated the levels of ·NO and protein 3-nitrotyrosine in the plasma of C3H and BALB/c mice and pharmacologically modulated their production during...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Peroxynitrite; Nitric oxide; Nitrotyrosine; Free radicals; Trypanosoma cruzi; Chagas' disease.
Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005001200011
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Proteomic inventory of myocardial proteins from patients with chronic Chagas' cardiomyopathy BJMBR
Teixeira,P.C.; Iwai,L.K.; Kuramoto,A.C.K.; Honorato,R.; Fiorelli,A.; Stolf,N.; Kalil,J.; Cunha-Neto,E..
Chronic Chagas' disease cardiomyopathy (CCC) is an often fatal outcome of Trypanosoma cruzi infection, with a poorer prognosis than other cardiomyopathies. CCC is refractory to heart failure treatments, and is the major indication of heart transplantation in Latin America. A diffuse myocarditis, plus intense myocardial hypertrophy, damage and fibrosis, in the presence of very few T. cruzi forms, are the histopathological hallmarks of CCC. To gain a better understanding of the pathophysiology of CCC, we analyzed the protein profile in the affected CCC myocardium. Homogenates from left ventricular myocardial samples of end-stage CCC hearts explanted during heart transplantation were subjected to two-dimensional electrophoresis with Coomassie blue staining;...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Chagas' disease; Cardiomyopathy; Proteomic analysis; Two-dimensional electrophoresis; MALDI-ToF.
Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006001200005
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Reactivation of Chagas' disease leading to the diagnosis of acquired immunodeficiency syndrome BJID
Santos,Eder de Oliveira; Canela,João dos Reis; Monção,Henry Carlos Gomes; Roque,Mauro José Guedes.
Reactivation of chronic Chagas' disease is a rare condition and occurs only in immunosuppressed patients. We report a case of a patient with a rapid and fatal reactivation of Chagas' disease, manifested by meningoencephalitis, which lead to a diagnosis of acquired immunodeficiency syndrome (AIDS). We believe there is sufficient evidence to include the reactivation of Chagas' disease among the diagnostic criteria of AIDS in Human Immunodeficiency Virus (HIV) infection.
Tipo: Info:eu-repo/semantics/report Palavras-chave: Chagas' disease; Trypanosoma cruzi; Acquired immunodeficiency syndrome; Human immunodeficiency virus; Meningoencephalitis.
Ano: 2002 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702002000600009
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Sera from chronic chagasic patients depress cardiac electrogenesis and conduction BJMBR
Costa,P.C.S.; Fortes,F.S.A.; Machado,A.B.; Almeida,N.A.C.; Olivares,E.L.; Cabral,P.R.; Pedrosa,R.C.; Goldenberg,R.C.; Campos-de-Carvalho,A.C.; Masuda,M.O..
We report results obtained with sera from 58 chronic chagasic patients that were evaluated for effects on heart rate and atrioventricular (AV) conduction in isolated rabbit hearts and screened for the presence of muscarinic and beta-adrenergic activity. We show that sera from 26 patients decreased heart rate, while 10 increased it and 22 had no effect. Additionally, sera from 20 of the 58 patients blocked AV conduction. Muscarinic activation seems to be involved in both effects, but is not the only mechanism, since atropine did not antagonize the decrease in heart rate in 23% of sera or AV block in 40%. Sera from patients with complex arrhythmias were significantly more effective in depressing both heart rate and AV conduction. Sera that induce increases...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Chagas' disease; Antibodies; Muscarinic activation; Beta-adrenergic activation; Gap junction; Mammalian heart.
Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000400010
Registros recuperados: 25
Primeira ... 12 ... Última
 

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