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Acremonium kiliense infection in a child with chronic granulomatous disease BJID
Pastorino,Antonio Carlos; Menezes,Ulissis Pádua de; Marques,Heloisa Helena de Souza; Vallada,Marcelo G.; Cappellozi,Vera Lúcia; Carnide,Eugénia Maria Grilo; Jacob,Cristina Miuki Abe.
Infection by unusual microorganisms can be one of the clinical manifestations of primary immunodeficiency (PID). We report on a four-month-old child with pneumonia caused by the fungus Acremonium kiliense as the first clinical manifestation of chronic granulomatous disease. We emphasize the importance of an active search for unusual organisms in immunodeficient patients, and a precise diagnosis and early institution of specific treatment against such microorganisms for the reduction of the morbidity and mortality of these patients.
Tipo: Info:eu-repo/semantics/report Palavras-chave: Infancy; Immunodeficiency; Chronic granulomatous disease; Fungi; Acremonium.
Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000600014
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Chronic granulomatous disease: why an inflammatory disease? BJMBR
Roxo-Junior,P.; Simão,H.M.L..
Chronic granulomatous disease is a primary immunodeficiency caused by mutations in the genes encoding subunits of the phagocytic NADPH oxidase system. Patients can present with severe, recurrent infections and noninfectious conditions. Among the latter, inflammatory manifestations are predominant, especially granulomas and colitis. In this article, we systematically review the possible mechanisms of hyperinflammation in this rare primary immunodeficiency condition and their correlations with clinical aspects.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Chronic granulomatous disease; Inflammation; Infection; Granulomas; NADPH oxidase.
Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2014001100924
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