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	Provedor de dados BJMBR (1) J. Venom. Anim. Toxins (1) J. Venom. Anim. Toxins incl. Trop. Dis. (1) Autor Antonelli,L (1) BELLÓ,A. A. (1) Fonteles,M.C. (1) Fortes-Dias,CL (1) HAMPE,O. G. (1) Martins,A.M.C. (1) Monteiro,H.S.A. (1) Pujatti,PB (1) Santos,RG (1) Silva,I.M.S.C. da (1) Soares,MA (1) Mais... Palavra-chave Crotalus durissus terrificus venom (3) Crotoxin (2) Antitumoral effect (1) Crotamine (1) Glioblastoma multiforme (1) Kidney (1) Method to estimate the concentration (1) Pituitary adenoma (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Info:eu-repo/semantics/other (1) Ano 2010 (1) 2001 (1) 1997 (1) País Brazil (3) Idioma Inglês (3)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 3 Primeira ... 1 ... Última Actions of Crotalus durissus terrificus venom and crotoxin on the isolated rat kidney BJMBR Monteiro,H.S.A.; Silva,I.M.S.C. da; Martins,A.M.C.; Fonteles,M.C.. Many studies have reported the occurrence of lethal acute renal failure after snakebites. The aim of the present investigation was to determine alterations in renal function produced by Crotalus durissus terrificus venom and crotoxin as well as the histological alterations induced by these venoms. Isolated kidneys from Wistar rats weighing 240 to 280 g were perfused with Krebs-Henseleit solution containing 6 g% of previously dialyzed bovine serum albumin. The effects of Crotalus durissus terrificus venom and crotoxin were studied on glomerular filtration rate (GFR), urinary flow (UF), perfusion pressure (PP) and percentage sodium tubular transport (%TNa+). The infusion of Crotalus durissus terrificus venom (10 µg/ml) and crotoxin (10 µg/ml) increased GFR... Tipo: Info:eu-repo/semantics/article Palavras-chave: Crotalus durissus terrificus venom; Crotoxin; Kidney. Ano: 2001 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001001000017 AN in vivo METHOD FOR ESTIMATING THE CONCENTRATION OF CROTAMINE IN A SOLUTION J. Venom. Anim. Toxins HAMPE,O. G.; BELLÓ,A. A.. very sensitive method for estimating the concentration of crotamine in a solution was developed. This method was based on the time required for the appearance of permanent hyperextension of the rear legs of mice as a function of the dose administered. This method can be used to determine toxin doses as low as 0.32 mg/kg<img SRC="http:/img/fbpe/jvat/v3n1/image2875.gif"> . Its high specificity for crotamine means that it can be used to measure toxin concentrations in the presence of other proteins and polypeptides. Tipo: Info:eu-repo/semantics/other Palavras-chave: Crotalus durissus terrificus venom; Crotamine; Method to estimate the concentration. Ano: 1997 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-79301997000100004 Crotalus durissus terrificus venom as a source of antitumoral agents J. Venom. Anim. Toxins incl. Trop. Dis. Soares,MA; Pujatti,PB; Fortes-Dias,CL; Antonelli,L; Santos,RG. The basic knowledge on neoplasms is increasing quickly; however, few advances have been achieved in clinical therapy against tumors. For this reason, the development of alternative drugs is relevant in the attempt to improve prognosis and to increase patients' survival. Snake venoms are natural sources of bioactive substances with therapeutic potential. The objective of this work was to identify and characterize the antitumoral effect of Crotalus durissus terrificus venom (CV) and its polypeptide, crotoxin, on benign and malignant tumors, respectively, pituitary adenoma and glioblastoma. The results demonstrated that CV possess a powerful antitumoral effect on benign (pituitary adenoma) and malignant (glioblastoma multiforme) tumors with IC50 values of... Tipo: Info:eu-repo/semantics/article Palavras-chave: Crotalus durissus terrificus venom; Crotoxin; Antitumoral effect; Pituitary adenoma; Glioblastoma multiforme. Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992010000300015 Registros recuperados: 3 Primeira ... 1 ... Última

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