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Effects of oxysterols on cell viability, inflammatory cytokines, VEGF, and reactive oxygen species production on human retinal cells: cytoprotective effects and prevention of VEGF secretion by resveratrol Inra
Dugas, B.; Charbonnier, S.; Baarine, M.; Ragot, K.; Delmas, D.; Menetrier, F.; Lherminier, J.; Malvitte, L.; Khalfaoui, T.; Bron, A.; Creuzot Garcher, C.; Latruffe, N.; Lizard, G..
Background and aimsOxysterols are assumed to play important roles in age-related macular degeneration, a major cause of blindness. So we characterized the cytotoxic, oxidative, inflammatory, and angiogenic activities of oxysterols (7β-hydroxycholesterol (7β-OH), 7-ketocholesterol (7KC), 25-hydroxycholesterol (25-OH)) in human retinal ARPE-19 cells, and evaluated the protective effects of resveratrol (Rsv: 1 μM), a polyphenol from red wine.MethodsARPE-19 cells were treated with 7β-OH, 7KC, or 25-OH (5–40 μg/mL; 24–48 h) without or with Rsv. Cell viability was determined using trypan blue and the MTT assay. Cell death was characterized by electron microscopy and in situ detection of activated caspases with fluorochrome-labeled inhibitors of caspases....
Tipo: Journal Article Palavras-chave: CELLULES RÉTINIENNES; DEGENERESCENCE MACULAIRE; DMLA ARPE-19 CELLS; CASPASE-INDEPENDENT CELL DEATH; INFLAMMATORY CYTOKINES; OXYSTEROLS; PHOSPHOLIPIDOSIS; RESVERATROL; REACTIVE OXYGEN SPECIES; VEGF.
Ano: 2010 URL: http://www.prodinra.inra.fr/prodinra/pinra/doc.xsp?id=PROD201135a1139e&uri=/notices/prodinra1/2011/06/
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Genetic variants in BCMO1 and CD36 are associated with plasma lutein concentrations and macular pigment optical density in humans Inra
Borel, P.; Szabo de Edelenyi, F.; Vincent-Baudry, S.; Malezet-Desmoulins, C.; Margotat, A.; Lyan, B.; Gorrand, J.M.; Meunier, N.; Drouault-Holowacz, S.; Bieulevet, S..
Lutein is recovered at high concentration in the human macula lutea. Recent studies suggest that this micronutrient might be implicated in prevention of age-related macular degeneration. Objective: to identify genes which affect blood and retina lutein concentrations among candidate genes (intestinal sterol transporters and carotenoid oxygenases). Design: a comparative plus an observational study. Participants: Twenty nine healthy subjects for the comparative study and 622 subjects for the observational study. Intervention and methods: All the participants were genotyped for single nucleotide polymorphisms (SNPs) in the candidate genes. Fasting plasma lutein concentrations were measured in all the participants and after six months supplementation, with...
Tipo: Journal Article Palavras-chave: LUTEINE; REGRESSION LINEAIRE; RETINE; VISION; DEGENERESCENCE MACULAIRE; OEIL HUMAIN; SYSTEME SENSORIEL AGE-RELATED MACULAR DEGENERATION; BIOAVAILABILITY; CAROTENOIDS; EYE; GENETIC POLYMORPHISM; GENETIC VARIANT; NUTRITION; RETINA; XANTHOPHYLLS.
Ano: 2010 URL: http://www.prodinra.inra.fr/prodinra/pinra/doc.xsp?id=PROD201041c748bc&uri=/notices/prodinra1/2010/11/
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rs5888 variant of SCARB1 gene is a possible susceptibility factor for age-related macular degeneration Inra
Zerbib, J.; Seddon, J.M.; Richard, F.; Reynolds, R.; Levéziel, N.; Benlian, P.; Borel, P.; Feingold, J.; Munnich, A.; Soubrane, G.; Kaplan, J.; Rozet, J.M.; Souied, E.H..
Major genetic factors for age-related macular degeneration (AMD) have recently been identified as susceptibility risk factors,including variants in the CFH gene and the ARMS2 LOC387715/HTRA1locus. Our purpose was to perform a case-control studyin two populations among individuals who did not carry risk variants for CFHY402H and LOC387715 A69S (ARMS2), called‘‘study’’ individuals, in order to identify new genetic risk factors. Based on a candidate gene approach, we analyzed SNPrs5888 of the SCARB1 gene, coding for SRBI, which is involved in the lipid and lutein pathways. This study was conducted ina French series of 1241 AMD patients and 297 controls, and in a North American series of 1257 patients with advanced AMDand 1732 controls. Among these...
Tipo: Journal Article Palavras-chave: DMLA; DEGENERESCENCE MACULAIRE; MALADIE DE L'OEIL; PREVENTION DES RISQUES; CHOLESTEROL; POLYMORPHISME; LUTEINE; VITAMINE E; RETINE HUMAINE AMD; MACULAR DEGENERATION; HUMAN HEALTH; ANTIOXIDANT; RISK FACTOR; LUTEIN; VITAMIN E; LIPIDS.
Ano: 2009 URL: http://www.prodinra.inra.fr/prodinra/pinra/doc.xsp?id=PROD2009961264e2&uri=/notices/prodinra1/2009/10/
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