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	Provedor de dados 60 (2) Autor Chavarria-Bolaños,Daniel (1) Coban,Ozlem (1) Degim,Zelihagul (1) Esparza-Villalpando,Vicente (1) Pozos-Guillén,Amaury (1) Vértiz-Hernández,Antonio (1) Zapata-Morales,Juan Ramón (1) Mais... Palavra-chave Dexketoprofen trometamol (2) Antinociception/effects (1) Chlorhexidine (1) Dulbecco’s Modified Eagle Medium (1) Formalin test (1) Imatinib mesylate (1) Ultra Performance Liquid Chromatography (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2020 (1) 2018 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Antinociceptive local effect of the combination of dexketoprofen trometamol and chlorhexidine gluconate in a formalin test: an additive effect 60 Esparza-Villalpando,Vicente; Chavarria-Bolaños,Daniel; Zapata-Morales,Juan Ramón; Vértiz-Hernández,Antonio; Pozos-Guillén,Amaury. ABSTRACT A drug delivery system (DDS) with analgesic and antibacterial properties would be desirable for the local control of post-operatory pain and the prevention for surgical site infection (SSI). The objective of the present study was to evaluate the antinociceptive effect of the combination between dexketoprofen trometamol (DXT) and chlorhexidine gluconate (CHX) in the formalin pain model. Different doses of CHX were combined with DXT and were locally administered in rats paw simultaneously with 5% formalin dilution. Flinches were documented and the antinociceptive effect was calculated. The area under the curve of each experimental group were calculated and the % of antinociception were compared. The groups of CHX and DXT showed similar... Tipo: Info:eu-repo/semantics/article Palavras-chave: Antinociception/effects; Formalin test; Dexketoprofen trometamol; Chlorhexidine. Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000200601 Development and validation of highly selective method for the determination of imatinib mesylate and dexketoprofen trometamol combination in three different media 60 Coban,Ozlem; Degim,Zelihagul. Imatinib mesylate is a small molecule used in cancer therapy as a thyrosine kinase inhibitor. Dexketoprofen trometamol is a non-steroidal anti-inflammatory drug that has seen use in cancer therapy in combination with an anticancer drug to minimize tumor size and to reduce pain in patients. In the present study, imatinib mesylate and dexketoprofen trometamol were selected as potential model drugs to be used in combination. A new, simple and selective Ultra Performance Liquid Chromatography method was developed and validated to determine the drug substances in distilled water, in a pH 7.4 phosphate buffer and in Dulbecco’s Modified Eagle Medium. The proposed method was developed using a BEH C-18 column with isocratic elution. A mixture of... Tipo: Info:eu-repo/semantics/article Palavras-chave: Imatinib mesylate; Dexketoprofen trometamol; Ultra Performance Liquid Chromatography; Dulbecco’s Modified Eagle Medium. Ano: 2020 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100575 Registros recuperados: 2 Primeira ... 1 ... Última

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