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Toxicological and pharmacological evaluation of Discaria americana Gillies & Hook (Rhamnaceae) in mice BJPS
Silva,Eliane Regina da; Diedrich,Denise; Bolzan,Rodrigo Cordeiro; Giacomelli,Sandro Rogério.
Medicinal plants (e.g. Discaria americana) have been used by populations for centuries. However, popular use is not enough to validate these plants as safe and effective medicinal products. The present study sought to evaluate the acute and subacute toxicity as well as the anxiolytic and antinociceptive effects of D. americana root bark and aerial parts extracts in mice. In acute toxicity studies, mice were treated with single intraperitoneal doses of the aforementioned extracts. Subacute toxicity studies were performed by oral administration of the extracts over 14 days. Anxiolytic studies consisted of the elevated plus maze method, and antinociceptive studies were based on the hot plate test. The LD50 value for D. americana aerial parts extract was...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Discaria americana/phamacognosy; Medicinal plants; Discaria americana/toxicological analysis; Discaria americana/acute toxicity; Discaria americana/subacute toxicity; Discaria americana/anxiolytic effect; Discaria americana/antinociceptive effect.
Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502012000200011
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