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Alginate/hydrophobic HPMC (60M) particulate systems: new matrix for site-specific and controlled drug delivery BJPS
Ghosal,Kajal; Ray,Sarbani Dey.
This study aimed to obtain site-specific and controlled drug release particulate systems. Some particulates were prepared using different concentrations of sodium alginate (Na-Alg) alone and others were formulated using different proportions of Na-Alg with hydroxypropyl methylcellulose (HPMC) stearoxy ether (60M viscosity grade), a hydrophobic form of conventional HPMC, using diclofenac potassium (DP) by ion-exchange methods. Beads were characterized by encapsulation efficiency, release profile, swelling, and erosion rate. The suitability of common empirical (zero-order, first-order and Higuchi) and semi-empirical (Ritger-Peppas and Peppas-Sahlin) models was studied to describe the drug release profile. The Weibull model was also studied. Models were...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Drugs/release particulate systems; Drugs/release profile; Hydroxypropyl methylcellulose stearoxy ether; Sodium alginate; Direct fitting; Case II transport; Beads/characterization; Beads/release kinetics.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502011000400021
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Formulation and in vitro evaluation of mucoadhesive controlled release matrix tablets of flurbiprofen using response surface methodology BJPS
Khalid,Ikrima; Ahmad,Mahmood; Minhas,Muhammad Usman; Sohail,Muhammad.
The objective of the current study was to formulate mucoadhesive controlled release matrix tablets of flurbiprofen and to optimize its drug release profile and bioadhesion using response surface methodology. Tablets were prepared via a direct compression technique and evaluated for in vitro dissolution parameters and bioadhesive strength. A central composite design for two factors at five levels each was employed for the study. Carbopol 934 and sodium carboxymethylcellulose were taken as independent variables. Fourier transform infrared (FTIR) spectroscopy studies were performed to observe the stability of the drug during direct compression and to check for a drug-polymer interaction. Various kinetic models were applied to evaluate drug release from the...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Flurbifrofen/mucoadhesive controlled release tablets/formulation; Flurbifrofen/mucoadhesive controlled release tablets/in vitroevaluation; Drugs/release profile; Drugs/bioadhesion; Tablets/direct compression.
Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000300493
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