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| JIMÉNEZ,AP; IREGUI,CA; FIGUEROA,J. |
| A partir de una cepa de A. hydrophila aislada de un brote de enfermedad septicémica en Tilapia nilótica (Piaractus brachypomusoreochromis niloticus), se obtuvieron extractos de lipopolisacárido (LPS) crudo (29,5 mg/ml) y semipurificado (106,5 mg/ml) mediante la técnica fenol-agua caliente descrita por Westphal, Jann (1965). La presencia de proteína fue del 2,3% para el extracto crudo y de 0,1% para el semipurificado; la concentración de polisacáridos osciló entre el 15 y 26%. En electroforesis (SDS-PAGE) se observaron bandas de 14 Kd correspondientes al oligosacárido central y al lípido A del LPS. Tres ratones de 25-35 g fueron inoculados intraperitonealmente con 25 mg/Kg de LPS cru-do, a partir de la primera hora todos los animales mostraron erizamiento,... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Lipopolisacárido (LPS); Aeromonas hydrophila; Peces; Endotoxemia; Proliferación de mononucleares. |
| Ano: 2008 |
URL: http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0120-548X2008000200010 |
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| Rosa,P.C.S.; Peiró,J.R.; Campebell,R.C.; Valadão,C.A.A.; Bechara,G.H.. |
| Fifteen healthy Mangalarga horses, aged two to three years were used to evaluate the possible beneficial effects of dexamethasone and sodium diclofenac administration during experimental endotoxemia in horses. They were divided into three groups with five animals each: control (C), sodium diclofenac (SD) and dexamethasone (DM). All groups were given 0.1µg of Escherichia coli O55:B5 endotoxin/kg of body weight, intravenous, over 15 minutes, and one of the following preparations: group C - 20ml of 0.9% saline intravenous, 30 minutes before endoxin infusion; group SD - 2.2mg/kg, per os, 60 minutes before endotoxin infusion and group DM - 1.1 mg/kg, intravenous, 30 minutes before endotoxin infusion. No increase in rectal temperature was observed in the SD or... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Endotoxemia; Equine; Peritoneal fluid; Sodium diclofenac; Dexamethasone. |
| Ano: 2003 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352003000300006 |
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| Campebell,R.C.; Peiró,J.R.; Rosa,P.C.S.; Valadão,C.A.A.; Bechara,G.H.. |
| Avaliou-se a inibição da produção do fator de necrose tumoral alfa (TNF-alfa) devido ao pré-tratamento com antiinflamatório esteroidal (dexametasona) e não esteroidal (diclofenaco sódico) em eqüinos com endotoxemia induzida experimentalmente. Foram utilizados 15 cavalos machos não castrados, distribuídos em três grupos de cinco animais: controle (C), diclofenaco sódico (DS) e dexametasona (DM). A endotoxemia subletal foi induzida pela infusão intravenosa (IV) de 0,1mg/kg/pv de lipopolissacarídeo (LPS) de Escherichia coli 055:B5, administrado em 250ml de solução estéril de cloreto de sódio a 0,9%, durante 15min. Os cavalos do grupo-controle foram tratados com solução de cloreto de sódio a 9% IV. Nos animais do grupo DS, administraram-se, por via oral,... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Eqüino; Citocina; TNF-alfa; Endotoxemia; Dexametasona; Diclofenaco sódico. |
| Ano: 2007 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352007000400003 |
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| Tang,B.; Qiao,H.; Meng,F.; Sun,X.. |
| Massive hepatectomy associated with infection induces liver dysfunction, or even multiple organ failure and death. Glycyrrhizin has been shown to exhibit anti-oxidant and anti-inflammatory activities. The aim of the present study was to investigate whether glycyrrhizin could attenuate endotoxin-induced acute liver injury after partial hepatectomy. Male Wistar rats (6 to 8 weeks old, weighing 200-250 g) were randomly assigned to three groups of 24 rats each: sham, saline and glycyrrhizin. Rats were injected intravenously with lipopolysaccharide (LPS) 24 h after 70% hepatectomy. Glycyrrhizin, pre-administered three times with 24 h intervals 48 h before hepatectomy, prolonged the survival of rats submitted to partial hepatectomy and LPS injection, compared... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Glycyrrhizin; Lipopolysaccharide; Hepatectomy; Inflammatory cytokine; Apoptosis; Endotoxemia. |
| Ano: 2007 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007001200007 |
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| Jiang,Yuanxu; Xia,Mingzhu; Huang,Qiang; Ding,Dengfeng; Li,Yali; Zhang,Zhongjun; Zhang,Xueping. |
| Dexmedetomidine (DEX), a selective agonist of α2-adrenergic receptors, has anti-inflammation properties and potential beneficial effects against trauma, shock, or infection. Therefore, this study aimed to investigate whether DEX might protect against multiple-organ dysfunction in a two-hit model of hemorrhage/resuscitation (HS) and subsequent endotoxemia. Eighty Wistar rats were randomized into four groups: NS (normal saline), HS/L (HS plus lipopolysaccharide), HS/L+D (HS/L plus dexmedetomidine), and HS/L+D+Y (HS/L+D plus yohimbine). Six hours after resuscitation, blood gas (PaO2) and serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), blood urine nitrogen (BUN), creatinine (Cr), TNF-α, IL-β, IL-6, IL-8, IL-10, and nitric oxide (NO)... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Hemorrhagic shock; Resuscitation; Endotoxemia; Dexmedetomidine; Yohimbine. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2019000300604 |
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