|
|
|
|
|
| Jemaa, Mohamed; Morin, Nathalie; Cavelier, Patricia; Cau, Julien; Strub, Jean Marc; Delsert, Claude. |
| Long-lived animals show a non-observable age-related decline in immune defense, which is provided by blood cells that derive from self-renewing stem cells. The oldest living animals are bivalves. Yet, the origin of hemocytes, the cells involved in innate immunity, is unknown in bivalves and current knowledge about mollusk adult somatic stem cells is scarce. Here we identify a population of adult somatic precursor cells and show their differentiation into hemocytes. Oyster gill contains an as yet unreported irregularly folded structure (IFS) with stem-like cells bathing into the hemolymph. BrdU labeling revealed that the stem-like cells in the gill epithelium and in the nearby hemolymph replicate DNA. Proliferation of this cell population was further... |
| Tipo: Text |
Palavras-chave: Hematopoiesis; Adult somatic progenitor cells; Hemocytes; Mollusk; Marine invertebrates. |
| Ano: 2014 |
URL: http://archimer.ifremer.fr/doc/00197/30802/29172.pdf |
| |
|
| |
|
| |
|
|
| Santos, Ed Wilson; Dias, Carolina; Oliveira, Dalila Cunha de; Hastreiter, Araceli; Silva, Graziela Batista da; Beltran, Jackeline Soares de Oliveira; Paredes-Gamero, Edgar Julian; Borelli, Primavera. |
| Protein Malnutrition (PM) can promotes the modification of hematopoietic tissue, with changes of extracellular matrix components, affecting the evolution of the cell cycle of hemopoietic cells, reducing the production of precursors and hematopoietic cells both in erythroid series and in the number of leukocytes, leading to anemia and leukopenia. In view of these events, it was hypothetised that changes can occur in the formation and establishment of bone marrow stroma, as well as in cells proliferation, differentiation and maturation, resulting in the change in the microenvironment inducing hemopoese, affecting signaling cellular processes and the physiology of stem and progenitor cells |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Hematopoiesis; Protein malnutrition; Bone marrow; Stromal cells; Mice hematopoiesis; Protein malnutrition; Bone marrow; Stromal cells; Mice. |
| Ano: 2016 |
URL: http://www.revistamvez-crmvsp.com.br/index.php/recmvz/article/view/31114 |
| |
|
|
| Tirape, Ana; Bacque, Coralie; Brizard, Raphael; Vandenbulcke, Franck; Boulo, Viviane. |
| The work presented here reports the expression of immune-related genes during ontogenesis in the oyster Crassostrea gigar. Expression patterns of 18 selected genes showed that RNAs detected in oocytes and 2-4 cell embryos are of maternal origin and that gene transcription starts early after fertilization. The expression patterns of 4 genes (Cg-timp, Cg-tal, Cg-EcSOD and Drac3) suggested that hemocytes appear in the gastrula-trochophore stages. The localization of Cg-tal expression suggested that hematopoietic cells were derived from vessels and/or artery endothelia cells. Moreover, a bacterial challenge affected the level of expression of genes. Indeed, a change in expression levels was observed for Cg-LBP/BPI, Cg-timp, Drac3 and Cg-MyD88 genes in larval... |
| Tipo: Text |
Palavras-chave: Rel/NF kappa B pathway; Cell proliferation; Hematopoiesis; Mollusk immunity; Hemocytes; Bivalve mollusk. |
| Ano: 2007 |
URL: http://archimer.ifremer.fr/doc/2007/publication-2612.pdf |
| |
|
|
| Bodi,Estevão; Hurtado,Sandra P.; Carvalho,Marcelo A.; Borojevic,Radovan; Carvalho,Antônio C. Campos de. |
| We examined gap junction communication in an in vitro model of hematopoiesis, using the murine bone marrow stroma cell line S-17, and primary cultures of murine marrow-derived blood cell precursors. S-17 cells express several connexins, the major one being connexin 43. Connexin expression and formation of functional gap junctions is modulated by stroma cell density. Transfection of S-17 cells with a vector containing connexin 43 sense or anti-sense sequences increased or decreased, respectively, connexin 43 synthesis and intercellular dye coupling. Under these conditions, modulation of gap junction-mediated communication modified the growth pattern of stroma itself, as well as the ability of the stroma to sustain hematopoiesis. Increased connexin 43... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Bone marrow; Hematopoiesis; Connexins; Gap junctions; S-17 cells. |
| Ano: 2004 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652004000400009 |
| |
|
|
| WEI,BIN; YUAN,SUOMAO; GAO,YINGMAO; BING,LUJUN. |
| Several major vascular tissues, such as the aorta-gonad-mesonephros región (AGM), yolk sac, and fetal liver have been confirmed to possess hematopoietic function. Recently, the placenta has been demonstrated as another hematopoietic organ. However, it is not conclusive whether the placenta possesses hematopoietic ability. Therefore, we undertook a series of experiments to study the hematopoietic functions of placenta. Fetal blood circulation in the placenta is difficult to be eliminated and its interference in the study of placental hematopoiesis is inevitable. With the application of placental flushing, fetal blood contained in the placenta was eliminated. We then made the further study of placental hematopoiesis after the El2.5 placenta was flushed. Our... |
| Tipo: Journal article |
Palavras-chave: Placenta; Hematopoiesis; HS/PCs; Mouse. |
| Ano: 2008 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602008000300003 |
| |
|
| |
|
|
| Nardi,N.B.; Alfonso,Z.Z.C.. |
| All blood cells are derived from a small common pool of totipotent cells, called hematopoietic stem cells. The process is strictly regulated by the hematopoietic microenvironment, which includes stromal cells, extracellular matrix molecules and soluble regulatory factors. Several experimental in vitro assays have been developed for the study of hematopoietic differentiation, and have provided valuable information on the stroma, which includes, among other cell types, macrophages, fibroblasts, adipocytes, and endothelial cells. The composition, ontogeny, and function in physiological as well as pathological conditions of stroma are discussed. |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Hematopoiesis; Microenvironment; Stroma. |
| Ano: 1999 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000500014 |
| |
|
|
|
