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Acute pancreatitis and acute renal failure following multiple hornet stings J. Venom. Anim. Toxins incl. Trop. Dis.
Sharma,N.; Balamurugeshan,P. K.; Sharma,A..
Hymenoptera is a class of insects that sting in order to subdue their prey. Humans coming into accidental contact with these insects results in stings that may cause from mild local reaction like weal formation around the sting site to severe systemic reactions such as intravascular hemolysis, acute renal failure, pulmonary edema, cerebral edema, and rarely pancreatitis. We report here the clinical course of a patient who developed concurrent acute pancreatitis and pigment-induced acute renal failure after multiple hornet stings.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Hymenoptera; Acute renal failure; Rhabdomyolysis; Hemolysis; Pancreatitis; Hornet stings.
Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992006000200012
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An experimental model of hemolysis-induced acute pancreatitis BJMBR
Saruc,M.; Yuceyar,H.; Turkel,N.; Ozutemiz,O.; Tuzcuoglu,I.; Yuce,G.; Huseyinov,A..
The literature indicates that acute pancreatitis is a complication of massive hemolysis with a prevalence of about 20%. We describe an experimental model of hemolysis-induced acute pancreatitis. Hemolytic anemia was induced in rats by a single ip injection of 60 mg/kg of 20 mg/ml acetylphenylhydrazine (APH) in 20% (v/v) ethanol on the first experimental day (day 0). One hundred and fifty Wistar albino rats weighing 180-200 g were divided into three groups of 50 animals each: groups 1, 2 and 3 were injected ip with APH, 20% ethanol, and physiological saline, respectively. Ten rats from each group were sacrificed on study days 1, 2, 3, 4 and 5. Serum amylase, lipase levels and pancreatic tissue tumor necrosis factor-alpha (TNF-alpha) and platelet-activating...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Hemolysis; Pancreatitis model; Experimental pancreatitis; Etiology; Pathology.
Ano: 2003 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000700008
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Antimicrobial susceptibility, hemolysis, and hemagglutination among Aeromonas spp. isolated from water of a bovine abattoir BJM
Bizani,Delmar; Brandelli,Adriano.
The presence of Aeromonas spp. in food has been demonstrated. They are often introduced from water, which is the natural habitat of many species and is thought to be the main source of contamination. The occurrence of Aeromonas spp. was investigated in 70 water samples of a bovine abattoir. Aeromonas spp. were present in 21.4% of water samples. A. hydrophila was isolated from 11.4% of supplying water samples and from 25.7% of the water drained from carcasses, whereas A. sobria was sole isolated from 5.7% of supplying water samples. Although greater number of positive samples were from water drained from carcasses, only A. hydrophila isolates were present. This suggests that the supplying water is the source of contamination. The antibiotic susceptibility...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Aeromonas; Antibiotic activity; Aquatic environment; Hemolysis; Water.
Ano: 2001 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822001000400016
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Bioactivities of extracts from the marine sponge Halichondria panicea J. Venom. Anim. Toxins incl. Trop. Dis.
Purushottama,GB; Venkateshvaran,K; Pani Prasad,K; Nalini,P.
In the present study, we screened the biological activity of extracts from the marine sponge Halichondria panicea collected in the Arabian Sea. Crude toxin was obtained by methanol, chloroform-methanol (2:1) and aqueous extraction. Subsequently, the protein concentration of each crude extract was determined. The impact of both sponge methanolic and aqueous extracts was found to increase activities of Na+-K+ ATP-ase and Mg++ ATP-ase. In the case of chloroform-methanol extract, higher concentrations increased acetylcholine esterase (AchE) activity. The methanolic and chloroform-methanol extracts exhibited hemolytic activity on chicken and human erythrocytes, whereas the aqueous extract failed to do so. Methanol and aqueous extracts produced an...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Halichondria panicea; Phagocytosis; Neuromodulation; Hemolysis; Angiogenesis.
Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992009000300007
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Characteristics of hemolytic activity induced by skin secretions of the frog Kaloula pulchra hainana J. Venom. Anim. Toxins incl. Trop. Dis.
Wei,Shuangshuang; Chi,Tingting; Meng,Aiyun; Chen,Congwei; An,Tianchen; Wang,Manchuriga; Zhang,Yingxia.
Background The hemolytic activity of skin secretions obtained by stimulating the frog Kaloula pulchra hainana with diethyl ether was tested using human, cattle, rabbit, and chicken erythrocytes. The skin secretions had a significant concentration-dependent hemolytic effect on erythrocytes. The hemolytic activity of the skin secretions was studied in the presence of osmotic protectants (polyethylene glycols and carbohydrates), cations (Mg2+, Ca2+, Ba2+, Cu2+, and K+), or antioxidants (ascorbic acid, reduced glutathione, and cysteine). Results Depending on their molecular mass, osmotic protectants effectively inhibited hemolysis. The inhibition of skin hemolysis was observed after treatment with polyethylene glycols (1000, 3400, and 6000 Da). Among divalent...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Amphibian; Skin secretions; Hemolysis; Pore-forming.
Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992013000100306
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Chemical composition, phytotoxic potential, biological activities and antioxidant properties of Myrcia hatschbachii D. Legrand essential oil BJPS
Gatto,Larissa Junqueira; Fabri,Natasha Tiemi; Souza,Angela Maria de; Fonseca,Natasha Stopinski Triaquim da; Furusho,Alethéia dos Santos; Miguel,Obdulio Gomes; Dias,Josiane de Fatima Gaspari; Zanin,Sandra Maria Warumby; Miguel,Marilis Dallarmi.
Myrcia hatschbachii D. Legrand (Myrtaceae) is a native and endemic species from Brazil. This study investigated the essential oil composition, phytotoxic potential, in vitro toxicity, antioxidant properties and antibacterial activity of species. Chromatographic analysis of essential oil identified trans-calamanene, (E)-caryophyllene and spathulenol as major components. Antioxidant capacity was determined by the DPPH• scavenging method and phosphomolybdenum complex formation assay. Antibacterial activity was evaluated using the Minimal Inhibitory Concentration test, demonstrating that the essential oil was active toward Enterococcus faecalis and Staphylococcus aureus. Phytotoxic activity of essential oil was analyzed by testing interference on germination...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Essential oil; Phytotoxic; Antioxidant; Antibacterial; Hemolysis; Artemia salina.
Ano: 2020 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100560
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Clinical aspects of hemolysis in patients with P. vivax malaria treated with primaquine, in the Brazilian Amazon BJID
Ramos Júnior,Wilson M; Sardinha,José FJ; Costa,Mônica RF; Santana,Marli S; Alecrim,Maria GC; Lacerda,Marcus VG.
This report describes the development of hemolysis in eighteen glucose-6-phosphate dehydrogenase deficient patients treated for Plasmodium vivax malaria with chloroquine and primaquine. The most frequent findings accompanying hemolysis were fever and leukocytosis, in addition to anemia requiring red blood cell transfusion, and development of acute renal failure. Hemolysis in patients using primaquine is not infrequent and contributes to the morbidity of infection caused by Plasmodium vivax.
Tipo: Info:eu-repo/semantics/other Palavras-chave: Malaria; Plasmodium vivax; Treatment; Primaquine; Hemolysis.
Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000400017
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Composition and biological activities of the aqueous extracts of three scleractinian corals from the Mexican Caribbean: Pseudodiploria strigosa, Porites astreoides and Siderastrea siderea J. Venom. Anim. Toxins incl. Trop. Dis.
García-Arredondo,Alejandro; Rojas-Molina,Alejandra; Ibarra-Alvarado,César; Lazcano-Pérez,Fernando; Arreguín-Espinosa,Roberto; Sánchez-Rodríguez,Judith.
Abstract Background: Scleractinian corals (stony corals) are the most abundant reef-forming cnidarians found in coral reefs throughout the world. Despite their abundance and ecological importance, information about the diversity of their toxins and their biological activities is very scarce. In this study, the chemical composition and the biological activities of the aqueous extracts of Pseudodiploria strigosa, Porites astreoides and Siderastrea siderea, three scleractinian corals from the Mexican Caribbean, have been assessed for the first time. Methods: Toxicity of the extracts was assessed in crickets; the presence of cytolysins was detected by the hemolysis assay; the vasoconstrictor activity was determined by the isolated rat aortic ring assay; the...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Scleractinia; Pseudodiploria strigosa; Porites astreoides; Siderastrea siderea; Toxicity; Hemolysis; Vasoconstriction; Nociceptive response.
Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992016000100323
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Cytolytic and systemic toxic effects induced by the aqueous extract of the fire coral Millepora alcicornis collected in the Mexican Caribbean and detection of two types of cytolisins J. Venom. Anim. Toxins incl. Trop. Dis.
Hernández-Matehuala,Rosalina; Rojas-Molina,Alejandra; Vuelvas-Solórzano,Alma Angelica; Garcia-Arredondo,Alejandro; Ibarra Alvarado,Cesar; Olguín-López,Norma; Aguilar,Manuel.
AbstractBackground Millepora alcicornis is a branching hydrocoral common throughout the Caribbean Sea. Like other members of this genus, this species is capable of inducing skin eruptions and blisters with severe pain after contact. In the present study, we investigated the toxicity of theM. alcicornis aqueous extract on several animal models. Considering that some cnidarian hemolysins have been associated to local tissue damage, since they also induce lysis of other cell types, we also made a partial characterization of the hemolytic activity of M. alcicornis aqueous extract. This information is important for understanding the defense mechanisms of the “fire corals”.Methods The effects of pH, temperature, and some divalent cations on the hemolytic...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Fire coral; Millepora alcicornis; Hemolysis; Systemic toxicity; Electronic microscopy.
Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992015000100342
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Determination of Hemolytic Activity of Different Strains of Trichomonads of Genus Trichomonas Donné, 1836 and Tritrichomonas Kofoid, 1920 OAK
Carli, Geraldo A. De; Brasseur, Philippe; Rott, Marilise B.; Da Silva, Ana C.; Wendorff, Aline; Benchimol, Marlene.
Palavras-chave: Hemolysis; Trichomonas vaginalis; Trichomonas gallinae; Tritrichomonas foetus; Tritrichomonas suis.
Ano: 1994 URL: http://ir.obihiro.ac.jp/dspace/handle/10322/217
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Effects of different general anesthetics on serum hemolysis and hepatic and muscular glycogenolysis in rats BJMBR
Machado,E.F.A.; Normand,A.C.R.; Nunes,L.A.S.; Brenzikofer,R.; Macedo,D.V..
Anesthetics can affect the structure and biological function of tissues and systems differentially. The aim of the present study was to compare three injectable anesthetics generally used in experiments with animals in terms of the degree of hemolysis and glycogenolysis occurring after profound anesthesia. Twenty-four male Wistar rats (330-440 g) were divided into three groups (N = 8): chloral hydrate (CH), ketamine + xylazine (KX), Zoletil 50® (zolazepam and tiletamine) + xylazine (ZTX). After deep anesthesia, total blood was collected. The liver and white (WG) and red gastrocnemius (RG) muscles were also immediately removed. The degree of serum hemolysis was quantified on the basis of hemoglobin concentration (g/L). Hepatic and muscular glycogen...
Tipo: Info:eu-repo/semantics/other Palavras-chave: General anesthetic; Rats; Glycogenolysis; Hemolysis; Zoletil; Ketamine.
Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009001100006
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EFFECTS OF THREE FRACTIONS OBTAINED FROM Naja haje VENOM ON HEMOLYSIS AND LIPID METABOLISM IN RABBITS J. Venom. Anim. Toxins
EL-AAL,A. A.; EZZAT,A. R..
Three fractions (F1, F2 and F3) were obtained from the venom of the Egyptian cobra Naja haje by gel filtration. F1 and F2 had indirect hemolytic effects on rabbit erythrocytes. The HU50 (the amount of the fraction causing 50% hemolysis ) values of F1 and F2 were 12.04 ± 3.89 and 36.57 ± 2.20 µg, respectively. The effects of the three cobra venom fractions on lipid metabolism were studied after 1, 2, 3 and 4 hours. Serum total lipids and cholesterol were significantly decreased at almost all tested times, but variable changes were observed in the serum triglycerides. Serum inorganic phosphorus levels were significantly increased with F1 and F2 administration more than that with the F3 fraction. These results suggest that F1 and F2 possess phospholipase...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Naja haje venom fractions; Hemolysis; Total lipids; Cholesterol; Triglycerides; Inorganic phosphorus.
Ano: 1997 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-79301997000200007
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Evaluation of free radical-scavenging and antihemolytic activities of quince (Cydonia oblonga) leaf: A comparative study with green tea (Camellia sinensis) IPB - Escola Superior Agrária
Costa, R.M.; Magalhães, A.S.; Pereira, J.A.; Andrade, P.B.; Valentão, P.; Carvalho, M.; Silva, B.M..
This study aimed to determine the phenolic profile and to investigate the antioxidant potential of quince (Cydonia oblonga) leaf, comparing it with green tea (Camellia sinensis). For these purposes, methanolic extracts were prepared and phenolics content of quince leaf was determined by HPLC/UV. The antioxidant properties were assessed by Folin–Ciocalteu reducing capacity assay and by the ability to quench the stable free radical 2,20-diphenyl-1-picrylhydrazyl (DPPH) and to inhibit the 2,20-azobis(2-amidinopropane) dihydrochloride (AAPH)-induced oxidative hemolysis of human erythrocytes. 5-O-Caffeoylquinic acid was found to be the major phenolic compound in quince leaf extract. Quince leaf exhibited a significantly higher reducing power than green tea...
Tipo: Article Palavras-chave: Antioxidant activity; Cydonia oblonga; Quince leaf; Hemolysis; Phenolic compounds; Camellia sinensis.
Ano: 2009 URL: http://hdl.handle.net/10198/3044
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Hemagglutinating/Hemolytic activities in extracts of marine invertebrates from the Brazilian coast and isolation of two lectins from the marine sponge Cliona varians and the sea cucumber Holothuria grisea Anais da ABC (AABC)
Moura,Raniere M.; Melo,Arthur A.; Carneiro,Rômulo F.; Rodrigues,Cícera R.f.; Delatorre,Plínio; Nascimento,Kyria S.; Saker-Sampaio,Silvana; Nagano,Celso S.; Cavada,Benildo S.; Sampaio,Alexandre H..
Twenty species of marine invertebrates from the Brazilian coast were screened for hemagglutinating/hemolytic activity. In at least twelve tested species, hemagglutinating activity was different for different blood types, suggesting the presence of lectins. Extracts from four species showed hemolytic activity. Two new lectins were purified from the marine sponge Cliona varians (CvL-2) and sea cucumber Holothuria grisea (HGL). CvL-2 was able to agglutinate rabbit erythrocytes and was inhibited by galactosides. The hemagglutinating activity was optimal in pH neutral and temperatures below 70 °C. CvL-2 is a trimeric protein with subunits of 175 kDa. On the other hand, HGL showed both hemagglutinating and hemolytic activity in human and rabbit erythrocytes, but...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Purification; Hemolysis; Cytotoxicity; Galactose.
Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652015000200973
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Hematological, biochemical, and blood gas alterations of goat whole blood stored in CPDA-1 and CPD/SAG-M plastic bags Ciência Rural
Tavares,Marcondes Dias; Barros,Isabella de Oliveira; Sousa,Rejane dos Santos; Firmino,Paulo Ricardo; Gameleira,Jucelio da Silva; Oliveira,Francisco Leonardo Costa de; Minervino,Antonio Humberto Hamad; Ortolani,Enrico Lippi; Alves Barrêto-Júnior,Raimundo.
ABSTRACT: The aim of this study was to evaluate the hematological, biochemical, and blood gas alterations of goat whole blood stored in different blood bags. Seven male, adult, crossbreed goats were used, weighing 62±1.8 kg. Nine hundred milliliters of whole blood from each animal was collected and stored in blood bags (450 ml in each), CPDA-1 (citrate phosphate dextrose-adenine) and CPD/SAG-M (citrate phosphate dextrose with saline-glucose-mannitol) as additive solutions, and kept refrigerated (2-4 ºC) for 42 days. Blood samples were collected from the plastic bags at baseline (T0) and after seven, 14, 21,28, 35, and 42 days for hematological, biochemical, blood gas, and microbiological evaluations. Free hemoglobin, degree of hemolysis, lactate, and...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Transfusion; Red blood cell; Hemolysis; Blood therapy; Goats.
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782019001000604
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Hemolitic action of Naja naja atra cardiotoxin on erythrocytes from different animals J. Venom. Anim. Toxins incl. Trop. Dis.
Troiano,J. C.; Gould,E. G.; Gould,I..
A comparative study on the sensitivity of erythrocytes from different vertebrate species (avian, mammalian and reptilian) to the hemolytic action caused by cardiotoxin isolated from Naja naja atra venom was carried out. Cardiotoxin was able to induce direct hemolysis in washed erythrocytes from several animals, except for llama. The EC50 values from hemolysis of the most sensitive (cat) and the most resistant (snake) animal varied approximately tenfold. According to the cell behavior, it was possible to characterize four types of behavior: The first was observed in cat, horse and human cells; the second in rat, rabbit and dog erythrocytes; and the third only in llama erythrocytes, which were resistant to cardiotoxin concentrations up to 300 µg/ml. Finally,...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Hemolysis; Cobra; Venom; Erythrocytes; Animals.
Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992006000100004
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Hemolytic activity of venom from crown-of-thorns starfish Acanthaster planci spines J. Venom. Anim. Toxins incl. Trop. Dis.
Lee,Chi-Chiu; Tsai,Wann-Sheng; Hsieh,Hernyi Justin; Hwang,Deng-Fwu.
Background : The crown-of-thorns starfish Acanthaster planci is a venomous species from Taiwan whose venom provokes strong hemolytic activity. To understand the hemolytic properties of A. planci venom, samples were collected from A. planci spines in the Penghu Islands, dialyzed with distilled water, and lyophilized into A. planci spine venom (ASV) powder. Results : Both crude venom and ASV cause 50% hemolysis at a concentration of 20 μg/mL. The highest hemolytic activity of ASV was measured at pH 7.0-7.4; ASV-dependent hemolysis was sharply reduced when the pH was lower than 3 or greater than 8. There was almost no hemolytic activity when the Cu2+ concentration was increased to 10 mM. Furthermore, incubation at 100°C for 30 to 60 minutes sharply decreased...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Crown-of-thorns starfish; Spine; Venoms; Hemolysis.
Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992013000100312
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In vivo pharmacological study on the effectiveness of available polyclonal antivenom against Hemiscorpius lepturus venom J. Venom. Anim. Toxins incl. Trop. Dis.
Jalali,A; Pipelzadeh,M H; Seyedian,R; Rahmani,A H; Omidian,N.
The available Razi Institute antivenom is still, empirically, used by intramuscular (IM) administration for the treatment of scorpion stings in humans by six medically dangerous species including Hemiscorpius lepturus (H. lepturus). The aim of this study was to assess the neutralizing ability and effectiveness of the antivenom in inhibiting hemoglobinuria, biochemical changes, increased microalbuminuria and urinary lactate dehydrogenase (LDH) following H. lepturus sting. Simultaneous intramuscular administration of 10 μL and 100 μL of antivenom, after 24 hours, had no significant preventive effect on the extent and degree of hemoglobinuria or proteinuria produced in venom-treated rats. After IM administration of antivenom, no significant changes in...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Hemiscorpius lepturus; Scorpion; Venom; Hemolysis; Antivenom.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992011000200004
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Mentha pulegium crude extracts induce thiol oxidation and potentiate hemolysis when associated to t-butyl hydroperoxide in human’s erythrocytes Anais da ABC (AABC)
BIANCHINI,MATHEUS C.; GALVÃO,DENNYURA O.; TAMBORENA,TATIANA; ALVES,CLAUDIA O.; PUNTEL,ROBSON L..
ABSTRACT Mentha pulegium (Lamiaceae) tea has been used as a traditional medicine; however, the modulatory effect of M. pulegium extracts on damage to human erythrocytes associated to t-butyl hydroperoxide (t-BHP) exposure remains to be investigated. Accordingly, we perform this study in order to test the hypothesis that aqueous and ethanolic extracts of M. pulegium could modulate the hemolysis associated to t-BHP exposure, non-protein thiol (NPSH) oxidation and lipid peroxidation (measured as thiobarbituric acid reactive substances - TBARS) in human erythrocytes. Samples were co-incubated with t-BHP (4 mmol/L) and/or aqueous or ethanolic extracts (10-1000 mg/mL) during 120 min to further analysis. We found that both extracts, when associated to t-BHP,...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Mentha pulegium; Lamiaceae; Hemolysis; Lipid peroxidation; NPSH oxidation; Erythrocytes..
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000602901
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On some toxinological aspects of the starfish Stellaster equestris (Retzius, 1805) J. Venom. Anim. Toxins incl. Trop. Dis.
Kanagarajan,U; Bragadeeswaran,S; Venkateshvaran,K.
Whole-body extracts in methanol were obtained from the starfish Stellaster equestris. The crude toxin was fractionated stepwise using diethylaminoethyl (DEAE) cellulose column chromatography. The crude toxin was lethal to male albino mice at a dose of 1.00 mL (containing 531.0 µg/mL protein) when injected intraperitoneally (IP) but the toxicity was abolished in all cases except one upon fractionation. The crude toxin and all the adsorbed fractions exhibited potent hemolytic activity on chicken, goat and human blood. However, group B human erythrocytes were resistant to lysis by all fractions and group O by most of the fractions. Paw edema in mice was caused by the crude toxin and all fractions. Pheniramine maleate and piroxicam blocked the toxicity when...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Starfish; Toxicity; Hemolysis; Human blood groups; Paw edema.
Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992008000300005
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