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| Almeida, Felipe Natali; Universidade Estadual de Maringá; Andrade, Maynara Lucca; Universidade de São Paulo; Moreira, Gabriela Virginia; Universidade de São Paulo; Camporez, João Paulo Gabriel; Universidade de São Paulo; Chimin, Patricia; Universidade de São Paulo; Carvalho, Carla Roberta de Oliveira; Universidade de São Paulo. |
| Dehydroespiandrosterone (DHEA) is associated with improvements in chronic degenerative diseases, including obesity, insulin resistance, and cardiovascular diseases. Nevertheless, it is observed an increase in its concentration in individuals with liver lipid infiltration, but it is not precise if this condition emerges as a cause or a consequence. In this way, we aimed to identify gene expression alterations in lipid and glucose liver metabolism markers, as well as oxidative stress markers. For this purpose, male Wistar rats, 12-14 months old were treated with subcutaneous injections of DHEA (only dose of 10 mg kg-1); and after 7 days, hepatic gene expression by PCR real time were performed for the following genes: G6Pase, PEPCK, FAS, PPARγ, malic enzyme,... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Dehydroespiandrosterone; Hepatic steatosis; De novo lipogenesis; Hepatic insulin resistance. |
| Ano: 2014 |
URL: http://periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/19471 |
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| Li,Shan; Wang,Xiaoman; Zhang,Jielei; Li,Jingyi; Liu,Xiaogang; Ma,Yuanyuan; Han,Chao; Zhang,Lixia; Zheng,Lili. |
| Non-alcoholic fatty liver disease (NAFLD) is a common disease associated with metabolic syndrome and can lead to life-threatening complications like hepatic carcinoma and cirrhosis. Exenatide, a glucagon-like peptide-1 (GLP-1) receptor agonist antidiabetic drug, has the capacity to overcome insulin resistance and attenuate hepatic steatosis but the specific underlying mechanism is unclear. This study was designed to investigate the underlying molecular mechanisms of exenatide therapy on NAFLD. We used in vivo and in vitro techniques to investigate the protective effects of exenatide on fatty liver via fat mass and obesity associated gene (FTO) in a high-fat (HF) diet-induced NAFLD animal model and related cell culture model. Exenatide significantly... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: GLP-1; FTO; NAFLD; PI3K; Hepatic steatosis. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000800612 |
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| Tang,B; Yang,C; Hu,S; Sun,W; Pan,Z; Li,L; Wang,J. |
| ABSTRACT Over-accumulation of triglycerides (TGs) in goose hepatocytes leads to the formation of fatty acid liver. Phosphoenolpyruvate carboxylase kinase 1 (PEPCK) is regarded as the rate-limiting enzyme for gluconeogenesis, and there is evidence that PEPCK is involved in regulating hepatic glucolipid metabolism. Hence, we proposed that PEPCK may have a role in goose hepatic steatosis. To test our hypothesis, the present study was conducted to firstly determine the sequence characteristics of goose PEPCK and then to explore its role in overfeeding-induced fatty liver. Our results showed that goose PEPCK encodes a 622-amino-acids protein that contains highly conserved oxaloacetate-binding domain, kinase-1 and kinase-2 motifs. PEPCK had higher mRNA levels in... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Goose; PEPCK; Sequence characteristics; Hepatic steatosis; Primary hepatocytes. |
| Ano: 2020 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-635X2020000400302 |
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