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A Sustained Immune Response Supports Long-Term Antiviral Immune Priming in the Pacific Oyster, Crassostrea gigas ArchiMer
Lafont, Maxime; Vergnes, Agnes; Vidal-dupiol, Jeremie; De Lorgeril, Julien; Gueguen, Yannick; Haffner, Philippe; Petton, Bruno; Chaparro, Cristian; Barrachina, Celia; Destoumieux-garzon, Delphine; Mitta, Guillaume; Gourbal, Benjamin; Montagnani, Caroline.
Over the last decade, innate immune priming has been evidenced in many invertebrate phyla. If mechanistic models have been proposed, molecular studies aiming to substantiate these models have remained scarce. We reveal here the transcriptional signature associated with immune priming in the oyster Crassostrea gigas. Oysters were fully protected against Ostreid herpesvirus 1 (OsHV-1), a major oyster pathogen, after priming with poly(I·C), which mimics viral double-stranded RNA. Global analysis through RNA sequencing of oyster and viral genes after immune priming and viral infection revealed that poly(I·C) induces a strong antiviral response that impairs OsHV-1 replication. Protection is based on a sustained upregulation of immune genes, notably genes...
Tipo: Text Palavras-chave: Innate immunity; Priming; OsHV-1; Antiviral response; Immune memory; Oyster; POMS; Poly(I·C); Interferon; Transcriptomic.
Ano: 2020 URL: https://archimer.ifremer.fr/doc/00614/72580/71541.pdf
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Computational approach of the homeostatic turnover of memory B cells. Repositório Alice
CASTRO, A. de; FRONZA, C. F.; ANSELMO, J..
In this paper, a discrete mathematical model inspired by control mechanisms is used to explore the factors potentially responsible for maximum immunization capacity in mammals. The results have been discussed in light of recent work, and refer to the adoption of parameter values chosen among data gathered from the literature. The model used in this study took into consideration that the immune system is a network of molecules and cells that can recognize itself.
Tipo: Artigo em periódico indexado (ALICE) Palavras-chave: Células B; Memória imune; Immune memory; Homeostatic turnover; Equilíbrio homeostático; Modelo matemático; Mathematical models; Memory.
Ano: 2014 URL: http://www.alice.cnptia.embrapa.br/handle/doc/999572
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In silico approach for viral mutations and sustainability of immunizations. Repositório Alice
CASTRO, A. de.
In this paper we use virtual samples of individuals and a dynamical modeling proposed in a previous study to study the behavior of immune memory against antigenic mutation.
Tipo: Artigo em periódico indexado (ALICE) Palavras-chave: Memória imunológica; Imunologia computacional; Estocasticidade; Mutação viral; Células B; Vacina; Immune memory; Computational immunology; Viral mutation; Stochasticity; B cells; Imunologia; Mutação; Immunology; Immunologic memory; Mutation; Stochastic processes; Vaccines.
Ano: 2015 URL: http://www.alice.cnptia.embrapa.br/handle/doc/1030086
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