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Effect of felodipine on myocardial and renal injury induced by aldosterone-high salt hypertension in uninephrectomized rats BJMBR
Matsubara,B.B.; Franco,M.; Janicki,J.S.; Matsubara,L.S..
It has been recently shown that calcium channel blockers might have a protective effect on cardiac fibrogenesis induced by aldosterone. The objective of this study was to evaluate the protective effect of felodipine, a dihydropyridine calcium channel blocker, against heart and kidney damage caused by aldosterone-high sodium intake in uninephrectomized rats. Wistar rats were divided into three groups: CNEP (uninephrectomized + 1% NaCl in the drinking water, N = 9); ALDO (same as CNEP group plus continuous infusion of 0.75 µg/h aldosterone, N = 12); ALDOF (same as ALDO group plus 30 mg·kg-1·day-1 felodipine in the drinking water, N = 10). All results were compared with those of age-matched, untreated rats (CTL group, N = 10). After 6 weeks, tail cuff blood...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Aldosterone; Dihydropyridine; Fibrinoid necrosis; Vascular remodeling; Hypertension; Myocardial remodeling.
Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010000500013
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