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N-Myristoyltransferases as antileishmanial targets: a piggyback approach with benzoheterocyclic analogues BJPS
Junqueira,Luis Otávio; Costa,Marcela Oliveira Legramanti da; Rando,Daniela Gonçales Galasse.
Leishmaniasis is one of the neglected diseases that remain in need for pharmacological alternatives. In this context, N-Myristoyltransferases (NMT) arise as interesting targets to explore since they are involved in the co/post-translational processing of peptides which are responsible for host cell invasion. Studies that consider these enzymes as targets point out the potential of benzoheterocyclic compounds as inhibitors of Candida albicans’s N-myristoyltransferase. Here we applied a combination of comparative binding site analysis and molecular docking studies based on a Piggyback approach in the search for new Leishmania major NMT ligands. Our results revealed that NMT enzymes from both pathogens present enough structural similarity to allow...
Tipo: Info:eu-repo/semantics/article Palavras-chave: N-myristoyltransferase; Leishmaniasis; Benzofuran; Benzothiazole; Molecular docking; Leishmania major.
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502019000100562
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