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	Provedor de dados BJMBR (2) Autor Augusto,O. (1) Barbeiro,H.V. (1) Carvalho,M.H.C. (1) Gomez,S.I (1) Laurindo,F.R.M. (1) Pedro,M.A. (1) Romero,J.C. (1) Strick,D.M. (1) da-Luz,P.L. (1) Mais... Palavra-chave NG-nitro-L-arginine methyl ester (2) Arginine analogues (1) Free radicals (1) Kidney (1) Meclofenamate (1) NG-methyl-D-arginine (1) NG-methyl-L-arginine (1) Renal circulation (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2008 (1) 1998 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Nonspecific blockade of vascular free radical signals by methylated arginine analogues BJMBR Pedro,M.A.; Augusto,O.; Barbeiro,H.V.; Carvalho,M.H.C.; da-Luz,P.L.; Laurindo,F.R.M.. Methylated arginine analogues are often used as probes of the effect of nitric oxide; however, their specificity is unclear and seems to be frequently overestimated. This study analyzed the effects of NG-methyl-L-arginine (L-NMMA) on the endothelium-dependent release of vascular superoxide radicals triggered by increased flow. Plasma ascorbyl radical signals measured by direct electron paramagnetic resonance spectroscopy in 25 rabbits increased by 3.8 ± 0.7 nmol/l vs baseline (28.7 ± 1.4 nmol/l, P<0.001) in response to papaverine-induced flow increases of 121 ± 12%. In contrast, after similar papaverine-induced flow increases simultaneously with L-NMMA infusions, ascorbyl levels were not significantly changed compared to baseline. Similar results... Tipo: Info:eu-repo/semantics/article Palavras-chave: Free radicals; Arginine analogues; NG-methyl-L-arginine; NG-methyl-D-arginine; NG-nitro-L-arginine methyl ester. Ano: 1998 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000600004 Role of nitric oxide and prostaglandin in the maintenance of cortical and renal medullary blood flow BJMBR Gomez,S.I; Strick,D.M.; Romero,J.C.. This study was undertaken in anesthetized dogs to evaluate the relative participation of prostaglandins (PGs) and nitric oxide (NO) in the maintenance of total renal blood flow (TRBF), and renal medullary blood flow (RMBF). It was hypothesized that the inhibition of NO should impair cortical and medullary circulation because of the synthesis of this compound in the endothelial cells of these two territories. In contrast, under normal conditions of perfusion pressure PG synthesis is confined to the renal medulla. Hence PG inhibition should predominantly impair the medullary circulation. The initial administration of 25 µM kg-1 min-1 NG-nitro-L-arginine methyl ester produced a significant 26% decrease in TRBF and a concomitant 34% fall in RMBF, while the... Tipo: Info:eu-repo/semantics/article Palavras-chave: Kidney; NG-nitro-L-arginine methyl ester; Meclofenamate; Renal circulation. Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008000200014 Registros recuperados: 2 Primeira ... 1 ... Última

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