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Anti-adipogenic effect of a turmeric extract-loaded nanoemulsion in 3T3-L1 preadipocytes and high fat diet-fed mice Ciênc. Tecnol. Aliment.
HWANG,Jung Seok; LEE,Su Bi; CHOI,Mi-Jung; KIM,Jun Tae; SEO,Han Geuk.
Abstract We investigated the effects of a turmeric extract-loaded nanoemulsion (TENE) on lipid accumulation in 3T3-L1 adipocytes and in mice fed a high fat diet (HFD). The accumulation of intracellular lipid in 3T3-L1 adipocytes was significantly inhibited by TENE, according to Oil red O and Nile Red staining. This inhibitory effect of TENE on adipocyte differentiation was associated with lower expression levels of the adipocyte-specific genes, PPARγ, aP2, and C/EBPα. In HepG2 hepatocytes, TENE attenuated palmitate-induced intracellular accumulation of lipid and ROS. In mice fed a HFD, TENE significantly reduced the serum levels of total cholesterol, triglycerides, and LDL and increased HDL levels. These effects of TENE were accompanied by reductions in...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Adipogenic differentiation; High fat diet; Nanoemulsion; Turmeric; 3T3-L1 preadipocytes.
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612019000600439
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Effect of neoadjuvant chemotherapy on low-density lipoprotein (LDL) receptor and LDL receptor-related protein 1 (LRP-1) receptor in locally advanced breast cancer BJMBR
Pires,L.A.; Hegg,R.; Freitas,F.R.; Tavares,E.R.; Almeida,C.P.; Baracat,E.C.; Maranhão,R.C..
Low-density lipoprotein (LDL) receptors are overexpressed in most neoplastic cell lines and provide a mechanism for the internalization and concentration of drug-laden nanoemulsions that bind to these receptors. The aim of the present study was to determine whether the administration of standard chemotherapeutic schemes can alter the expression of LDL and LDL receptor-related protein 1 (LRP-1) receptors in breast carcinoma. Fragments of tumoral and normal breast tissue from 16 consecutive volunteer women with breast cancer in stage II or III were obtained from biopsies before the beginning of neoadjuvant chemotherapy and after chemotherapy, from fragments excised during mastectomy. Tissues were analyzed by immunohistochemistry for both receptors. Because...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Breast cancer; Lipoproteins; LDL receptor; LRP-1 receptor; Chemotherapy; Nanoemulsion; Drug delivery.
Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000600012
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Formulation, optimization, and characterization of snakehead fish (Ophiocephalus Striatus) powder nanoemulgel BJPS
Tungadi,Robert; Wicita,Prisca.
The aim of the present study was to characterize and evaluate nanoemulgel of snakehead fish powder (SFP) for the poorly water-soluble drug. SFP was formulated into nanoemulsion utilizing the best comparison of surfactant, co-surfactant, and oil. Diverse nanoemulsion components (oil, surfactant, and co-surfactant) were chosen based on solvency and emulsification capacity. SFP 0.1% loaded nanoemulsion which tested by stress-stability testing which carried out for all formulations and those that passed these tests were characterized for droplet size, polydispersity index (PDI), zeta potential, pH, viscosity, and transmittance. After that, nanoemulsion was added with 1.5%, 2.0%, and 2.5% of HPMC in different concentrations and mixed until nanoemulgel form and...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Nanoemulgel; Nanoemulsion; Powder; Particle size analyzer; Snakehead fish.
Ano: 2020 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100503
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Hyaluronic acid-coated nanoemulsions loaded with a hydrophobic ion pair of all-trans retinoic acid for improving the anticancer activity BJPS
Tinoco,Letícia Márcia da Silva; Silva,Flávia Lidiane Oliveira da; Ferreira,Lucas Antônio Miranda; Leite,Elaine Amaral; Carneiro,Guilherme.
All-trans retinoic acid (ATRA) has been studied for the treatment of cancer, including leukemia and breast cancer. This work aims to develop nanoemulsions (NE) loaded with a hydrophobic ion pair (HIP) of all-trans retinoic acid (ATRA) and a lipophilic amine, stearylamine (SA), and coated with hyaluronic acid (HA) to enhance anticancer activity and reducing toxicity. Blank NE was prepared by spontaneous emulsification and optimized prior to HIP incorporation. NE-ATRA was electrostatically coated with different concentrations of HA. Incorporation of ATRA-SA led to monodisperse NE with small size (129 ± 2 nm; IP 0.18 ± 0.005) and positive zeta potential (35.7 ± 1.0 mV). After coating with 0.5 mg/mL HA solution, the mean diameter slightly increased to 158 ± 5...
Tipo: Info:eu-repo/semantics/article Palavras-chave: All-trans-retinoic acid; Breast neoplasms.Drug delivery; Hyaluronic acid; Nanoemulsion.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000400616
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Influence of particle size on appearance and in vitro efficacy of sunscreens BJPS
Silva,Débora Granemann e; Sarruf,Fernanda Daud; Oliveira,Larissa Carolina Diniz de; Arêas,Elizabeth Pinheiro Gomes; Kaneko,Telma Mary; Consiglieri,Vladi Olga; Velasco,Maria Valéria Robles; Baby,André Rolim.
Nanotechnology applies to diverse sectors of science. In cosmetic area, investments have strengthened the idea that nanoproducts provide innumerable benefits to consumers. Extreme exposition to solar light can cause undesirable effects, thus, adding UV filters in cosmetic products are often used as prevention. Ethylhexyl methoxycinnamate and benzophenone-3 are UV filters widely used in sunscreen formulations, this UV filters absorb UVB and UVA radiation, respectively. In this study, sunscreen formulations were developed as nano and macroemulsion, but composed by the same raw material. Nanoemulsion was obtained by phase inversion temperature method (PIT). Physical and functional properties were evaluated by visual analysis, particle size distribution and by...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Nanoemulsion; PIT method; Benzophenone-3; Ethylhexyl methoxycinnamate.
Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000200007
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Nanoemulsion containing caffeine for cellulite treatment: characterization and in vitro evaluation BJPS
Freire,Thamires Batello; Dario,Michelli Ferrera; Mendes,Otávio Gil; Oliveira,Andressa Costa de; Vetore Neto,Alberto; Faria,Dalva Lucia Araújo de; Silva,Vânia Rodrigues Leite e; Baby,André Rolim; Velasco,Maria Valéria Robles.
The Ginoide Hydrolipodystrophy (GHLD), commonly known as cellulite, occurs in 80-90% of the female population after the puberty period and comes from a metabolic modification in the cutaneous adipose tissue. Caffeine has been used in topical formulations due to its lipolytic action. We studied a nanoemulsion (F3) containing caffeine with two surfactants (oleth-3 and oleth-20) by emulsification method by phase inversion temperature inversion (PIT). The polydispersion indices (PDI) showed the reduced deviation of 0.1. The mean droplet size was ~ 40 nm. The evaluated constant of Ostwald, in the refrigerator condition was the most favorable during the stability test. In the In Raman spectroscopy assay, the caffeine bands found in F3 were compatible with those...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Cellulite; Caffeine; Gynoid hydrolipodystrophy; Nanoemulsion; Permeation.
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502019000100567
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Optimized conditions to produce water-in-oil-in-water nanoemulsion and spray-dried nanocapsule of red ginseng extract Ciênc. Tecnol. Aliment.
MIN,Ji-Young; AHN,Sung-Il; LEE,Yun-Kyung; KWAK,Hae-Soo; CHANG,Yoon Hyuk.
Abstract The aim of this study was to optimize conditions for producing water-in-oil-in-water (W/O/W) nanoemulsion and spray-dried nanocapsule of red ginseng extract. Based on emulsion stability and average particle size analysis, optimum conditions to produce W/O/W nanoemulsion were: ratio of core to coating material, 3:7; primary emulsifier, 10% polyglycerol polyricinoleate; ratio of W/O phase to coating material, 1.5:8.5; secondary emulsifier, 10% polyoxyethylene sorbitan monolaurate; solvent, 20% ethyl acetate; secondary coating material, 10% maltodextrin (MD). Under these optimized conditions, particle size of spray-dried nanocapsules coated with MD of red ginseng ranged from 100 nm to 500 nm, based on response surface methodology with the highest...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Red ginseng extract; Nanoemulsion; Spray-dried nanocapsule; Response surface methodology.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612018000300485
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Physicochemical characterization and evaluation of in vitro and in vivo toxicity of goldenberry extract nanoemulsion Ciência Rural
Silva,Suelen Santos da; Bazana,Maiara Taís; Deus,Cassandra de; Machado,Marina Lopes; Cordeiro,Larissa Marafiga; Soares,Félix Alexandre Antunes; Libreloto,Daniele Rubert Nogueira; Rolim,Clarice Madalena Bueno; Menezes,Cristiano Ragagnin de; Codevilla,Cristiane Franco.
ABSTRACT: Oil-in-water (O/W) nanoemulsion containing goldenberry extract was elaborated using a high-energy ultrasonic bath method. Physicochemical characterization of the formulation was carried out by determining pH, mean droplet diameter, polydispersity index (PDI) and zeta potential. Nanoemulsion toxicity was assessed using in vitro assays with tumor and non-tumor cell lines, and in vivo using Caenorhabditis elegans. The pH of the nanoemulsion was 3.84, the mean droplet diameter was 268 ± 7 nm, PDI 0.113 and zeta potential -13.94 mV. Results of the cytotoxicity assays employing non-tumor cells indicated that the extract associated or not with nanoemulsion maintained cell viability at different concentrations tested. In the assays using tumor lineage,...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Physalis peruviana; Nanoemulsion; Citotoxicity; C. elegans..
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782019000800754
Registros recuperados: 8
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