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Formulation design and characterization of a non-ionic surfactant based vesicular system for the sustained delivery of a new chondroprotective agent BJPS
Khan,Muhammad Imran; Madni,Asadullah; Ahmad,Saeed; Mahmood,Muhammad Ahmad; Rehman,Mubashar; Ashfaq,Muhammad.
Diacerein is used for symptomatic relief and cartilage regeneration in osteoarthritis. Due to gastrointestinal side effects, poor aqueous solubility and low bioavailability, its clinical usage has been restricted. The objective of the present study was to enhance its dissolution profile and to attain sustained release by designing a novel delivery system based on niosomes. Five niosomal formulations (F1-F5) with non-ionic surfactant (sorbitan monostearate) and cholesterol in varying ratios of 5:5, 6:4, 7:3, 8:2 and 9:1 were developed by the reverse-phase evaporation technique. The size and polydispersivity index (PDI) were found in the range of 0.608 µm to 1.010 µm and 0.409 to 0.781, respectively. Scanning electron microscopy (SEM) of the selected...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Chondroprotective; Diacerein/dissolution profile; Diacerein/sustained release; Niosomes; Sorbitan monostearate; Reverse-phase evaporation.
Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502015000300607
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LIPID VESICLES: APPLICATIONS, PRINCIPAL COMPONENTS AND METHODS USED IN THEIR FORMULATIONS. A REVIEW Acta biol.Colomb.
CAMILO,Cicera J.; LEITE,Débora O. D.; SILVA,Angelo R. A. e; MENEZES,Irwin R. A.; COUTINHO,Henrique D. M.; COSTA,José G. M. da.
ABSTRACT Liposomes and niosomes are currently the most studied lipid vesicles in the nanomedicine field. The system formed by a phospholipid bilayer in aqueous medium allows these vesicles to carry both hydrophilic and lipophilic compounds, providing an increase in solubility of drugs already used in conventional therapy. The focus on the development of these vesicles should be directed to determining the ideal composition, with low toxicity, biocompatibility and which remains stable for long periods. These characteristics are related to the components used for formulation and the substances that will be encapsulated. Another important point relates to the methods used during formulation, which are important in determining the type of vesicle formed,...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Components; Formulation; Liposomes; Nanomedicine; Niosomes.
Ano: 2020 URL: http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0120-548X2020000200339
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Niosomes and liposomes as promising carriers for dermal delivery of Annona squamosa extract BJPS
Mohamad,Ebtesam Abdelghany; Fahmy,Heba Mohamed.
The leaf extract of Annona squamosa L. has antibacterial, antidiabetic, antioxidant, and anticancerous activities. The present work aims to compare between liposomes and niosomes as carriers for A. squamosa extract to improve its transdermal bioavailability. Physical characterization for niosomes and liposomes was performed using: transmission electron microscope (TEM), scanning electron microscope (SEM) and Fourier transform infrared spectroscopy (FTIR). In addition, the encapsulation efficiency for A. squamosa in both carriers was evaluated and in-vitro drug release experiments were performed. The results proved the potential of both carriers to penetrate the outer layer of the skin (stratum corneum) which is considered as a strong barrier against the...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Annona squamosa; Dermal delivery; Liposomes; Niosomes.
Ano: 2020 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100525
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