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Glyphosate as a tool to produce shikimic acid in plants Planta Daninha
Matallo,M.B.; Almeida,S.D.B.; Franco,D.A.S.; Cerdeira,A.L.; Gazzeiro,D.L.P..
Oseltamivir phosphate is a potent viral inhibitor produced from shikimic acid extracted from seeds of Ilicium verum, the most important natural source. With the site of action 5-enolpyruvylshikimate-3-phosphate synthase (EPSP), glyphosate is the only compound capable of inhibiting its activity with the consequent accumulation of shikimic acid in plants. Corn and soybean plants were sprayed with reduced rates of glyphosate (0.0 to 230.4 g a.i. ha¹) and shikimic acid content in the dry mass was determined by HPLC 3, 7 and 10 days after application. Results showed shikimic acid accumulation in dry mass with increases of up to 969% in corn and 33,000% on soybeans, with peak concentrations 3 days after treatment (DAT). Industrial feasibility for shikimic acid...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Herbicides; Corn; Soybean; Oseltamivir; Pandemics; HPLC.
Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-83582014000300016
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Glyphosate on shikimic acid on Urochloa plantaginea. Repositório Alice
ALMEIDA, S. D. B. de; FRANCO, D. A. de S.; CERDEIRA, A. L.; QUEIROZ, S. C. do N. de; MATALLO, M. B..
Abstract: Shikimic acid (SA) has witnessed a strong increase in recent years due to the increasing demand of the pharmaceutical and cosmetic industry. The SA is used as a precursor for the synthesis of oseltamivir phosphate (Tamiflu®), a potent viral inhibitor and is extracted from the plant Illicium verum Hook which has a limited availability. This article proposed the use of Urochloa plantaginea (Link.) webster and glyphosate, as an alternative source of SA. U. plantaginea plants with 3 - 4 tillers and 4 - 6 leaves were harvest at 3, 6, 9 and 12 days after application (DAT) of low rates of glyphosate. Samples were dried, extracted, analyzed by HPLC and LC-MS/MS. The maximum SA concentrations were observed at 6 days after glyphosate at 36 g.a.e.ha-1 was...
Tipo: Artigo de periódico Palavras-chave: Oseltamivir phosphate; 5-enol pyruvyl shikimate-3-phosphate synthase (EPSPs); Fosfato de oseltamivir; Anis estrelado; EPSPs; Brachiaria Plantaginea; Herbicida; Planta Medicinal; Anis; Oseltamivir; Influenza; Illicium verum; Glyphosate; Shikimic acid.
Ano: 2020 URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1125411
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H5N1 avian influenza virus: an overview BJID
Proença-Módena,José Luiz; Macedo,Izolete Santos; Arruda,Eurico.
Avian influenza virus (H5N1) emerged in Hong Kong in 1997, causing severe human disease. In recent years, several outbreaks have been reported in different parts of Asia, Europe and Africa, raising concerns of dissemination of a new and highly lethal influenza pandemic. Although H5N1 has not been capable of sustaining human-to-human transmission, the ability of the virus to undergo variation due to mutations and reassortment, clearly poses the possibility of viral adaptation to the human species. For this reason the World Health Organization has established that we are now in a phase of pandemic alert. Preparing for an influenza pandemic involves a great deal of awareness necessary to stop initial outbreaks, through the use of case recognition, sensitive...
Tipo: Info:eu-repo/semantics/article Palavras-chave: H5N1 avian influenza virus; Pandemic influenza; Oseltamivir.
Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000100027
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