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	Provedor de dados BJMBR (3) Autor Cicogna,A.C. (3) Okoshi,K. (2) Okoshi,M.P. (2) Padovani,C.R. (2) Bonatto,R.C. (1) Campos,D.H.S. (1) Deus,A.F. (1) Fioretto,J.R. (1) Franco,M. (1) Freire,P.P. (1) Matsubara,B.B. (1) Matsubara,L.S. (1) Silveira,C.F.S.M.P. (1) Tucci,P.J.F. (1) Mais... Palavra-chave Papillary muscle (3) Afterload (1) Coronary vascular remodeling (1) Cyclopiazonic acid (1) DP/dt (1) DT/dt (1) Echocardiogram (1) Isolated diastolic dysfunction (1) Isometric contractions (1) Myocardial function (1) Pressure overload hypertrophy (1) Rat (1) Reparative fib (1) SERCA (1) Ventricular function (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Info:eu-repo/semantics/report (1) Ano 2017 (1) 1997 (2) País Brazil (3) Idioma Inglês (3)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 3 Primeira ... 1 ... Última Importance of SERCA2a on early isolated diastolic dysfunction induced by supravalvular aortic stenosis in rats BJMBR Silveira,C.F.S.M.P.; Campos,D.H.S.; Freire,P.P.; Deus,A.F.; Okoshi,K.; Padovani,C.R.; Cicogna,A.C.. Cardiac remodeling is defined as changes in shape and function of the heart in response to aggression (pressure overload). The sarcoplasmic reticulum calcium ATPase cardiac isoform 2a (SERCA2a) is a known factor that influences function. A wide spectrum of studies report a decrease in SERCA2a in heart failure, but none evaluate it's the role in early isolated diastolic dysfunction in supravalvular aortic stenosis (AoS). Our hypothesis was that SERCA2a participates in such dysfunction. Thirty-day-old male Wistar rats (60-80 g) were divided into AoS and Sham groups, which were submitted to surgery with or without aorta clipping, respectively. After 6 weeks, the animals were submitted to echocardiogram and functional analysis by isolated papillary muscle... Tipo: Info:eu-repo/semantics/report Palavras-chave: Papillary muscle; Echocardiogram; Cyclopiazonic acid; Rat; Isolated diastolic dysfunction; SERCA. Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017000500605 Myocyte necrosis is the basis for fibrosis in renovascular hypertensive rats BJMBR Okoshi,M.P.; Matsubara,L.S.; Franco,M.; Cicogna,A.C.; Matsubara,B.B.. The pathogenesis of fibrosis and the functional features of pressure overload myocardial hypertrophy are still controversial. The objectives of the present study were to evaluate the function and morphology of the hypertrophied myocardium in renovascular hypertensive (RHT) rats. Male Wistar rats were sacrificed at week 4 (RHT4) and 8 (RHT8) after unilateral renal ischemia (Goldblatt II hypertension model). Normotensive rats were used as controls. Myocardial function was analyzed in isolated papillary muscle preparations, morphological features were defined by light microscopy, and myocardial hydroxyproline concentration (HOP) was determined by spectrophotometry. Renal artery clipping resulted in elevated systolic arterial pressure (RHT4: 178 ± 19 mmHg and... Tipo: Info:eu-repo/semantics/article Palavras-chave: Coronary vascular remodeling; Myocardial function; Pressure overload hypertrophy; Papillary muscle; Reparative fib. Ano: 1997 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997000900013 The rate of force generation by the myocardium is not influenced by afterload BJMBR Fioretto,J.R.; Okoshi,M.P.; Okoshi,K.; Cicogna,A.C.; Bonatto,R.C.; Padovani,C.R.; Tucci,P.J.F.. The influence of afterload on the rate of force generation by the myocardium was investigated using two types of preparations: the in situ dog heart (dP/dt) and isolated papillary muscle of rats (dT/dt). Thirteen anesthetized, mechanically ventilated and thoracotomized dogs were submitted to pharmacological autonomic blockade (3.0 mg/kg oxprenolol plus 0.5 mg/kg atropine). A reservoir connected to the left atrium permitted the control of left ventricular end-diastolic pressure (LVEDP). A mechanical constriction of the descending thoracic aorta allowed to increase the systolic pressure in two steps of 20 mmHg (conditions H1 and H2) above control values (condition C). After arterial pressure elevations (systolic pressure C: 119 ± 8.1; H1: 142 ± 7.9; H2 166 ±... Tipo: Info:eu-repo/semantics/article Palavras-chave: Ventricular function; Afterload; DP/dt; DT/dt; Papillary muscle; Isometric contractions. Ano: 1997 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997001200015 Registros recuperados: 3 Primeira ... 1 ... Última

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