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EXPORT AND TRAFFICKING OF Plasmodium PROTEINS WITHIN THE HOST ERYTHROCYTE Acta biol.Colomb.
WISER,MARK F.
The export and trafficking of parasite proteins within the infected erythrocyte is a complex process and not well understood. Export of proteins from the parasite was previously speculated to involve a specialized compartment originally designated as the secondary endoplasmic reticulum of the Apicomplexa, or sERA. The properties of this Plasmodium export compartment are reviewed in regards to more recent observations about the trafficking of Plasmodium proteins within the host erythrocyte. In addition, a calcium ATPase unique to the Apicomplexa and with homology to the sarcoplasmicendoplasmic reticulum calcium ATPase is discussed in the context of this unique export compartment. It is also speculated that the Plasmodium export element, PEXEL, may play a...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Secretory pathway; SERCA; Protein trafficking; Malaria.
Ano: 2007 URL: http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0120-548X2007000200001
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Importance of SERCA2a on early isolated diastolic dysfunction induced by supravalvular aortic stenosis in rats BJMBR
Silveira,C.F.S.M.P.; Campos,D.H.S.; Freire,P.P.; Deus,A.F.; Okoshi,K.; Padovani,C.R.; Cicogna,A.C..
Cardiac remodeling is defined as changes in shape and function of the heart in response to aggression (pressure overload). The sarcoplasmic reticulum calcium ATPase cardiac isoform 2a (SERCA2a) is a known factor that influences function. A wide spectrum of studies report a decrease in SERCA2a in heart failure, but none evaluate it's the role in early isolated diastolic dysfunction in supravalvular aortic stenosis (AoS). Our hypothesis was that SERCA2a participates in such dysfunction. Thirty-day-old male Wistar rats (60-80 g) were divided into AoS and Sham groups, which were submitted to surgery with or without aorta clipping, respectively. After 6 weeks, the animals were submitted to echocardiogram and functional analysis by isolated papillary muscle...
Tipo: Info:eu-repo/semantics/report Palavras-chave: Papillary muscle; Echocardiogram; Cyclopiazonic acid; Rat; Isolated diastolic dysfunction; SERCA.
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017000500605
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