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Development and validation of dissolution method for carvedilol compression-coated tablets BJPS
Shah,Ritesh; Patel,Sachin; Patel,Hetal; Pandey,Sonia; Shah,Shailesh; Shah,Dinesh.
The present study describes the development and validation of a dissolution method for carvedilol compression-coated tablets. Dissolution test was performed using a TDT-06T dissolution apparatus. Based on the physiological conditions of the body, 0.1N hydrochloric acid was used as dissolution medium and release was monitored for 2 hours to verify the immediate release pattern of the drug in acidic pH, followed by pH 6.8 in citric-phosphate buffer for 22 hours, to simulate a sustained release pattern in the intestine. Influences of rotation speed and surfactant concentration in medium were evaluated. Samples were analysed by validated UV visible spectrophotometric method at 286 nm. 1% sodium lauryl sulphate (SLS) was found to be optimum for improving...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Carvedilol/coated tablets; Compression coated tablets/dissolution; PH 6.8 citric-phosphate buffer; Hydrochloric acid; Sodium lauryl sulphate.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502011000400027
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Formulation design and evaluation of Cefuroxime axetil 125 mg immediate release tablets using different concentration of sodium lauryl sulphate as solubility enhancer BJPS
Israr,Fozia; Mahmood,Zafar Alam; Hassan,Fouzia; Hasan,Syed Muhammad Farid; Jabeen,Sabahat; Naz,Shazia; Bashir,Lubna.
Cefuroxime axetil immediate release tablets were formulated by direct compression method with different percentages of sodium lauryl sulphate (SLS) such as 0.5, 1.0, 1.5 and also without SLS. Resulting batches of tablets were evaluated by both pharmacopeial and non-pharmacopeial methods to ascertain the physico-mechanical properties. Dissolution test were carried out in different medium like 0.07 M HCl, distilled water, 0.1M HCl of pH 1.2 and phosphate buffers at pH 4.5 and 6.8 to observe the drug release against the respective concentration of SLS used. Later, test formulations were compared by f1(dissimilarity) and f2(similarity) factors using a reference brand of cefuroxime axetil. Significant differences (p<0.05) in dissolution rate were recorded...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Cefuroxime axetil/immediate release tablets/physico-mechanical properties; Direct compression; Sodium lauryl sulphate.
Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000400943
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