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Registros recuperados: 7
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Anti-Sporothrix brasiliensis activity of different pyrazinoic acid prodrugs: a repurposing evaluation BJPS
Waller,Stefanie Bressan; Nakasu,Ceres; Silva,Anna Luiza; Faria,Renata Osório de; Fernandes,João Paulo dos Santos; Cleff,Marlete Brum.
From drug repurposing studies, this work aimed to evaluate the activity of different pyrazinoic acid (POA) derivatives against Sporothrix brasiliensis. The POA esters were prepared and characterized as previously reported by classical esterification reactions, with good to excellent yields. Sporothrix brasiliensis isolates from cats (n=6) and standard strains of S. brasiliensis and S. schenckii were used to assess the antifungal activity of the POA derivatives through broth microdilution assay (CLSI M38-A2). Among the tested compounds, molecules 3 and 4 showed fungistatic and fungicidal activities against all Sporothrix spp. strains, and the obtained MIC and MFC values ranged from 2.12 to 4.24 mg/mL and from 1.29 to 5.15 mg/mL, respectively. Compound 2 and...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Sporotrichosis; Sporothrix schenckii complex; Itraconazole; Antifungal resistance; Prodrugs; Pyrazinoic acid derivatives.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000400630
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Cytotoxicity and anti-Sporothrix brasiliensis activity of the Origanum majorana Linn. oil BJM
Waller,Stefanie Bressan; Madrid,Isabel Martins; Ferraz,Vanny; Picoli,Tony; Cleff,Marlete Brum; de Faria,Renata Osório; Meireles,Mário Carlos Araújo; de Mello,João Roberto Braga.
Abstract The study aimed to evaluate the anti-Sporothrix sp. activity of the essential oil of Origanum majorana Linn. (marjoram), its chemical analysis, and its cytotoxic activity. A total of 18 fungal isolates of Sporothrix brasiliensis (n: 17) from humans, dogs and cats, and a standard strain of Sporothrix schenckii (n: 1) were tested using the broth microdilution technique (Clinical and Laboratory Standard Institute - CLSI M27-A3) and the results were expressed in minimal inhibitory concentration (MIC) and minimal fungicidal concentration (MFC). The MIC50 and MIC90 of itraconazole against S. brasiliensis were 2 µg/mL and 8 µg/mL, respectively, and the MFC50 and MFC90 were 2 µg/mL and >16 µg/mL, respectively, with three S. brasiliensis isolates...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Sporotrichosis; Sporothrix schenckii complex; Antifungal resistance; Marjoram; Lamiaceae.
Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822016000400896
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Effects of essential oils of Rosmarinus officinalis Linn. and Origanum vulgare Linn. from different origins on Sporothrix brasiliensis and Sporothrix schenckii complex Arq. Bras. Med. Vet. Zootec.
Waller,S.B.; Madrid,I.M.; Cleff,M.B.; Santin,R.; Freitag,R.A.; Meireles,M.C.A.; Mello,J.R.B..
ABSTRACT Rosmarinus officinalis L. (rosemary) and Origanum vulgare L. (oregano) are known to have antimicrobial properties, but studies on sporotrichosis are scarce. This study aimed to evaluate the anti-Sporothrix spp. activity of essential oils from commercial products and oils extracted from aerial parts of these plants and analyze their chemical constituents. S. schenckii complex and S. brasiliensis (n: 25) isolated from humans, cats, dogs, and environmental soil were tested through M27-A3 guidelines of CLSI with modification for phytotherapics. The essential oils of R. officinalis L. were similar for MIC50 and MFC50 ≤2.25mg/mL for extracted oil; and 4.5mg/mL and 9mg/mL, respectively, for commercial oil. Both products showed MIC90 of 18mg/mL and MFC90...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Sporotrichosis; Antifungal resistance; Oregano; Rosemary; Lamiaceae.
Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352016000400991
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Efficacy of terbinafine and itraconazole on a experimental model of systemic sporotrichosis BJM
Meinerz,Ana Raquel Mano; Xavier,Melissa O.; Cleff,Marlete Brum; Madrid,Isabel Martins; Nobre,Márcia Oliveira; Meireles,Mário Carlos Araújo; Mello,João Roberto Braga de.
Itraconazole is currently considered the drug of choice to treat the diverse clinical presentation of sporotrichosis. On the other hand terbinafine by virtue of its excellent in vitro activity is under comparative evaluation for its therapeutic potential for a wide range of fungal infections. In this study, our aim was to determine the in vivo efficacy of terbinafine and itraconazole on a experimental model of systemic sporotrichosis. 120 rats Wistar received an injection of 2x10³ S. schenckii cells by via the lateral tail vein. After 3 days the animals were treated with terbinafine (250mg/kg) and itraconazole (100 mg/kg) and their respective diluents. In our model, terbinafine and itraconazole were effective in reducing the number of clinical lesions and...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Itraconazole; Terbinafine; Sporotrichosis; Antifungal.
Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822008000400025
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Isolation of Sporothrix schenkii from the nails of healthy cats BJM
Souza,Lorena Leonardo de; Nascente,Patrícia da Silva; Nobre,Márcia Oliveira; Meinerz,Ana Raquel Mano; Meireles,Mário Carlos Araújo.
Many cases of sporotrichosis in cats were diagnosed in the town of Rio Grande, RS, Brazil, caused mainly by inoculation due to scratches. In this work, we evaluated the frequency of Sporothrix schenckii in the nails of healthy cats living together with cats showing clinical sporotrichosis. The isolation of the fungus was carried out pressing unwashed nails of the forelimbs of 24 cats (48 paws) directly onto the surface of Mycobiotic Agar in Petri dishes. S. schenckii was isolated from seven (29.1%) cats. The procedure for isolation of the fungus was simpler than methods that require sedation and cuts of the nails.
Tipo: Info:eu-repo/semantics/other Palavras-chave: Sporotrichosis; Cats; Nails; Sporothrium schenckii.
Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822006000300031
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Phylogeography and evolutionary patterns in Sporothrix spanning more than 14 000 human and animal case reports Naturalis
Zhang, Y.; Hagen, F.; Stielow, B.; Rodrigues, A.M.; Samerpitak, K.; Zhou, X.; Feng, P.; Yang, L.; Chen, M.; Deng, S.; Li, S.; Liao, W.; Li, R.; Li, F.; Meis, J.F.; Guarro, J.; Teixeira, M.; Al-Zahrani, H.S.; Pires de Camargo, Z.; Zhang, L.; Hoog, G.S. de.
Pathology to vertebrate hosts has emerged repeatedly in the order Ophiostomatales. Occasional infections have been observed in Sporothrix mexicana at a low level of virulence, while the main pathogenic species cluster in a derived clade around S. schenckii s.str. In this paper, phylogeny and epidemiology of the members of this clade were investigated for 99 clinical and 36 environmental strains using four genetic loci, viz. rDNA ITS and partial CAL, TEF1, and TEF3; data are compared with amplified fragment length polymorphism (AFLP) genotyping. The four main species of the pathogenic clade were recognised. The species proved to show high degrees of endemicity, which enabled interpretation of literature data where live material or genetic information is...
Tipo: Article / Letter to the editor Palavras-chave: Epidemiology; Historical biogeography; Phylogeny; Sapronosis; Sporothrix; Sporotrichosis; Transmission routes; Yeast conversion; Zoonosis.
Ano: 2015 URL: http://www.repository.naturalis.nl/record/588679
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Sporothrix schenckii and sporotrichosis Anais da ABC (AABC)
Lopes-Bezerra,Leila M.; Schubach,Armando; Costa,Rosane O..
For a long time sporotrichosis has been regarded to have a low incidence in Brazil; however, recent studies demonstrate that not only the number of reported cases but also the incidence of more severe or atypical clinical forms of the disease are increasing. Recent data indicate that these more severe forms occur in about 10% of patients with confirmed diagnosis. The less frequent forms, mainly osteoarticular sporotrichosis, might be associated both with patient immunodepression and zoonotic transmission of the disease. The extracutaneous form and the atypical forms are a challenge to a newly developed serological test, introduced as an auxiliary tool for the diagnosis of unusual clinical forms of sporotrichosis.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Sporotrichosis; Diagnosis; Epidemiology; Drugs; Cell wall; Antigens.
Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652006000200009
Registros recuperados: 7
Primeira ... 1 ... Última
 

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