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Registros recuperados: 7
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Biogeography Revisited with Network Theory: Retracing the History of Hydrothermal Vent Communities ArchiMer
Moalic, Yann; Desbruyeres, Daniel; Duarte, Carlos M.; Rozenfeld, Alejandro F.; Bachraty, Charleyne; Arnaud-haond, Sophie.
Defining biogeographic provinces to understand the history and evolution of communities associated with a given kind of ecosystem is challenging and usually requires a priori assumptions to be made. We applied network theory, a holistic and exploratory method, to the most complete database of faunal distribution available on oceanic hydrothermal vents, environments which support fragmented and unstable ecosystems, to infer the processes driving their worldwide biogeography. Besides the identification of robust provinces, the network topology allowed us to identify preferential pathways that had hitherto been overlooked. These pathways are consistent with the previously proposed hypothesis of a role of plate tectonics in the biogeographical history of...
Tipo: Text Palavras-chave: Biogeography; Deep sea ecology; Hydrothermal vents; Network analysis; Systems biology.
Ano: 2012 URL: http://archimer.ifremer.fr/doc/00063/17400/15164.pdf
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Co-expression network analysis identifies genes associated with iron content in bovine muscle. Repositório Alice
DINIZ, W. J. da S.; CESAR, A. S. M.; GEISTLINGER, L.; TIZIOTO, P. C.; OLIVEIRA, P. S. N. de; AFONSO, J.; ROCHA, M. I. P.; LIMA, A. O. de; BUSS, C. E.; COUTINHO, L. L.; REGITANO, L. C. de A..
Editores: Luiz Lehmann Coutinho, ESALQ/USP; Luciana Correia de Almeida Regitano, Embrapa Pecuária Sudeste; Gerson Barreto Mourão, ESALQ/USP; Aline Silva Mello Cesar, ESALQ/USP; Bárbara Silva Vignato, FZEA/USP; Mirele Daiana Poleti, ESALQ/USP; Wellison Jarles da Silva Diniz, UFSCar.
Tipo: Resumo em anais de congresso (ALICE) Palavras-chave: Gene expression; Network analysis; Systems biology.
Ano: 2017 URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1075630
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Complex networks: the key to systems biology Genet. Mol. Biol.
Costa,Luciano da F.; Rodrigues,Francisco A.; Cristino,Alexandre S..
Though introduced recently, complex networks research has grown steadily because of its potential to represent, characterize and model a wide range of intricate natural systems and phenomena. Because of the intrinsic complexity and systemic organization of life, complex networks provide a specially promising framework for systems biology investigation. The current article is an up-to-date review of the major developments related to the application of complex networks in biology, with special attention focused on the more recent literature. The main concepts and models of complex networks are presented and illustrated in an accessible fashion. Three main types of networks are covered: transcriptional regulatory networks, protein-protein interaction networks...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Bioinformatics; Complex networks; Metabolic networks; Protein-protein networks; Systems biology; Transcription networks.
Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572008000400001
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Integrated analysis of the critical region 5p15.3–p15.2 associated with cri-du-chat syndrome Genet. Mol. Biol.
Corrêa,Thiago; Feltes,Bruno César; Riegel,Mariluce.
Abstract Cri-du-chat syndrome (CdCs) is one of the most common contiguous gene syndromes, with an incidence of 1:15,000 to 1:50,000 live births. To better understand the etiology of CdCs at the molecular level, we investigated theprotein–protein interaction (PPI) network within the critical chromosomal region 5p15.3–p15.2 associated with CdCs using systemsbiology. Data were extracted from cytogenomic findings from patients with CdCs. Based on clinical findings, molecular characterization of chromosomal rearrangements, and systems biology data, we explored possible genotype–phenotype correlations involving biological processes connected with CdCs candidate genes. We identified biological processes involving genes previously found to be associated with CdCs,...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Cri-du-Chat Syndrome; 5p– cytogenomics; Integrative Analysis; PPI; Systems biology.
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572019000200186
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Metabolic engineering: Use of system-level approaches and application to fuel production in Escherichia coli Electron. J. Biotechnol.
Gonzalez,Ramon.
Metabolic engineering was formally defined more than two decades ago (Bailey, 1991) and it is now an established discipline. Metabolic engineering is generally defined as the directed improvement of product formation or cellular properties through the modification of specific biochemical reactions or the introduction of new ones with the use of recombinant DNA technology (Bailey, 1991; Stephanopoulos et al. 1998). Therefore, the analysis and engineering/synthesis of metabolic pathways is of central importance to metabolic engineering. The analytical part uses a number of experimental and modeling techniques for the systematic study of cellular responses (in terms of RNA, protein and metabolite levels, metabolic fluxes, etc.) to genetic and environmental...
Tipo: Journal article Palavras-chave: Biofuels; Escherichia coli; Metabolic engineering; Systems biology.
Ano: 2013 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-34582013000300017
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Potential biomarkers for feed efficiency-related traits in nelore cattle identified by co-expression network and integrative genomics analyses. Repositório Alice
LIMA, A. O. de; KOLTES, J. E.; DINIZ, W. J. S.; OLIVEIRA, P. S. N. de; CESAR, A. S. M.; TIZIOTO, P. L.; AFONSO, J.; SOUZA, M. de S.; PETRINI, J.; ROCHA, M. I. P.; CARDOSO, T. F.; ZERLOTINI NETO, A.; COUTINHO, L. L.; MOURÃO, G. B.; REGITANO, L. C. de A..
Feed efficiency helps to reduce environmental impacts from livestock production, improving beef cattle profitability. We identified potential biomarkers (hub genes) for feed efficiency, by applying co-expression analysis in Longissimus thoracis RNA-Seq data from 180 Nelore steers. Six co-expression modules were associated with six feed efficiency-related traits (p-value ≤ 0.05). Within these modules, 391 hub genes were enriched for pathways as protein synthesis, muscle growth, and immune response. Trait-associated transcription factors (TFs) ELF1, ELK3, ETS1, FLI1, and TCF4, were identified with binding sites in at least one hub gene. Gene expression of CCDC80, FBLN5, SERPINF1, and OGN was associated with multiple feed efficiency-related traits...
Tipo: Artigo em periódico indexado (ALICE) Palavras-chave: Longissimus thoracis; Biomarcadores; Expressão gênica; Feed efficiency; Hub genes; Systems biology; WGCNA; Bos Indicus; Gene expression.
Ano: 2020 URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1124356
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Systems biology approach to study the high altitude adaptation in tibetans BABT
De,Bi; Huajun,Xiao; Cuihong,Zhou; Jun,Zhou; Xiaoyan,Deng; Xiaopeng,Liu.
The aim of this work was to study an integrative systems biology research strategy to construct a network including the protein-protein interactions (PPIs) and microRNAs (miRNAs) and identify the functional biological processes and pathways for high-altitude adaptation in Tibetans. The pathway enrichment analysis revealed that the genes in the network were mainly involved in signling the pathways and the function of microRNAs was concentrated in the signling pathways, which suggested that miRNAs might contribute to the Tibetans high-altitude adaptation through the participation in signaling pathway. These results contribute to better understanding on the high-altitude adaptation of the Tibetans.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Systems biology; Tibetan; High-altitude adaptation; Single nucleotide polymorphism; MicroRNA.
Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132013000100007
Registros recuperados: 7
Primeira ... 1 ... Última
 

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