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| Prezoto,B.C.; Maffei,F.H.A.; Mattar,L.; Chudzinski-Tavassi,A.M.; Curi,P.R.. |
| The venom of Lonomia obliqua caterpillar may induce a hemorrhagic syndrome in humans, and blood incoagulability by afibrinogenemia when intravenously injected in laboratory animals. The possible antithrombotic and thrombolytic activities of L. obliqua caterpillar bristle extract (LOCBE) were evaluated in this study. The minimal intravenous dose of the extract necessary to induce afibrinogenemia and anticoagulation was 3.0 and 10.0 µg protein/kg body weight for rabbits and rats, respectively. In rabbits, this dose induced total blood incoagulability for at least 10 h and did not reduce the weight of preformed venous thrombi, in contrast to streptokinase (30,000 IU/kg). In rats, pretreatment with 5.0 and 10.0 µg/kg LOCBE prevented the formation of thrombi... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Thrombosis; Fibrinolysis; Anticoagulant; Venom; Lonomia obliqua caterpillar. |
| Ano: 2002 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000600011 |
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| Schild,Carlos; Armendano,Joaquín Ignacio; Liboreiro,Matías; Bresky,Florencia; Morrell,Eleonora; Odriozola,Ernesto; Cantón,Germán. |
| ABSTRACT: Caudal vena cava thrombosis (CVCT) is an acute disease secondary to ruminal lactic acidosis and rumenitis with fatal outcome in cattle fed with a high-grain diet. The aim of this paper is to describe CVCT in an adult Holstein cow from a herd in Balcarce, Buenos Aires, Argentina. Clinical signs included dyspnea, weakness, recumbence, and hemoptysis, followed by death in 3.5 days. Important necropsy findings included multiple hepatic abscesses, a septic thrombus (4.0cm x 2.0cm) in the vena cava adjacent to the liver, and a 15cm hematoma in the right lung. Histological lesions observed in the pulmonary parenchyma included suppurative pneumonia with embolic bacterial colonies and severe interstitial fibroplasia. Dissociation and degeneration of... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Cattle; Holstein; Thrombosis; Vena cava; Hemoptysis. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782017000600551 |
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| Durand, E; Helley, D; Zen, A; Dujols, C; Bruneval, P; Colliec-jouault, Sylvia; Fischer, Aurelie; Lafont, A. |
| Background: Therapeutic use of unfractionated heparin and low molecular weight heparins (LMWHs) is limited by hemorrhagic adverse effects. We compared the antithrombotic effect of LMW fucoidan (LMWF) and LMWH in an experimental model. Methods: Thrombosis was induced in femoral arteries of male New Zealand White rabbits by in situ induction of endothelial apoptosis with staurosporine (10(-5) M for 30 min). Starting the day before apoptosis induction, the animals received subcutaneous LMWF (15 mg/kg), LMWH (enoxaparin 2.5 mg/kg) or saline solution (control group) twice a day for 4 days. Results: The degrees of apoptosis and endothelial denudation were similar in the 3 groups. The thrombotic score was significantly lower in the LMWF group than in the LMWH and... |
| Tipo: Text |
Palavras-chave: Tissue factor; Tissue factor pathway inhibitor; Heparin; Fucoidan; Thrombosis. |
| Ano: 2008 |
URL: http://archimer.ifremer.fr/doc/2008/publication-4744.pdf |
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| de Meis,E.; Azambuja,D.; Ayres-Silva,J.P.; Zamboni,M.; Pinheiro,V.R.; Levy,R.A.; Monteiro,R.Q.. |
| A correlation between cancer and hypercoagulability has been described for more than a century. Patients with cancer are at increased risk for thrombotic complications and the clotting initiator protein, tissue factor (TF), is possibly involved in this process. Moreover, TF may promote angiogenesis and tumor growth. In addition to TF, thrombin seems to play a relevant role in tumor biology, mainly through activation of protease-activated receptor-1 (PAR-1). In the present study, we prospectively studied 39 lung adenocarcinoma patients in relation to the tumor expression levels of TF and PAR-1 and their correlation with thrombosis outcome and survival. Immunohistochemical analysis showed TF positivity in 22 patients (56%), most of them in advanced stages... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Lung adenocarcinoma; Thrombosis; Tissue factor; Protease-activated receptor. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010000400012 |
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