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Avaliação da DL50 e edema pulmonar induzido pelo veneno de Tityus serrulatus (Scorpiones; Buthidae) procedente da Bahia, Brasil Biota Neotropica
Silva,Tiago F.; Casais-e-Silva,Luciana L.; Lira-da-Silva,Rejâne M..
O escorpião Tityus serrulatus é conhecido como a espécie mais importante, do ponto de vista médico, pois é o que causa os acidentes mais graves registrados para o território brasileiro. Este trabalho trata da caracterização do veneno do escorpião T. serrulatus, através da obtenção da DL50 e determinação da capacidade em induzir edema pulmonar, em ratos. O veneno foi obtido através de estímulo elétrico. A toxicidade foi determinada através da avaliação da DL50, pelo método de Finney (1971). Os valores demonstraram a baixa toxicidade do veneno (96,16 mg/camundongo), que corresponde a 3 - 7 vezes menos tóxico que venenos de espécimes de outras regiões do Brasil. O veneno testado também não induziu edema pulmonar, avaliado através da diferença entre o peso do...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Escorpião; Veneno; Tityus; Tityus serrulatus.
Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1676-06032005000200023
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Cardiorespiratory evaluation of juvenile rats experimentally envenomed with Tityus serrulatus venom J. Venom. Anim. Toxins incl. Trop. Dis.
Pinto,MCL; Melo,MB; Cruz,ML; Verçosa Junior,D; Melo,MM.
Accidental envenomation caused by Tityus serrulatus scorpions is very common in Brazil and may result in serious cardiorespiratory alterations that are frequently fatal to children. In the present study, the effects of T. serrulatus venom on the cardiorespiratory system of recently weaned male Wistar rats were evaluated. Fifteen animals were distributed into three groups (n = 5). The control group A received 400 μL ultrapure water by subcutaneous injection, while the experimental groups B and C were injected with scorpion venom (100 and 450 μg, respectively, in 400 μL water). Electrocardiogram (ECG) traces were obtained prior to the experiment, at five-minute intervals up to 30 minutes after treatment. At 40 minutes after envenomation, the animals had...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Tityus serrulatus; Rats; Electrocardiography; CK; CK-MB; Troponin; Pulmonary hemorrhages.
Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992010000200008
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Clinical and cardiovascular alterations produced by scorpion envenomation in dogs J. Venom. Anim. Toxins incl. Trop. Dis.
Cordeiro,F. F.; Sakate,M.; Fernandes,V.; Cuyumjian,P. R..
Scorpionism is a common problem that occurs in tropical and subtropical countries and assumes great medical-sanitary importance due to its fatal effect on sensitive individuals, being able to lead children and aged people to death. The envenomation lethal potential is responsible for the serious cardiopulmonary alterations the scorpion toxin produces in its victims. The present research evaluated the effects of Tityus serrulatus venom on dogs, using two distinct doses: a dose that simulates natural envenomation (0.4 mg/total dose), and an experimental dose (0.25 mg/kg). General clinical signs were observed at different moments after envenomation, and specific data related to the cardiopulmonary system were evaluated by systemic arterial pressure...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Scorpion; Dogs; Cardiopulmonary alterations; Tityus serrulatus.
Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992006000100003
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Convulsive effects of some isolated venom fractions of the Tityus serrulatus scorpion: behavioral, electroencephalographic, and neuropathological aspects J. Venom. Anim. Toxins
CARVALHO,F. F.; NENCIONI,A. L. A.; LEBRUN,I.; DORCE,V. A. C.; SANDOVAL,M. R. L..
It has been previously shown that the crude venom of Tityus serrulatus can cause convulsions. This study was designed to investigate the neurotoxic effects of B, C, G, and K fractions isolated from this venom. Intravenous injection of these fractions in mice (0.6 - 6.0 mg/kg body weight) showed that the C fraction is a potent convulsant and G fraction decreased the threshold for tonic hand limb extension elicited by transauricular electroshock. Unilateral injection of B, C, and K fractions, but not G fraction, into the hippocampus of rats (0.6 - 6.0 µg) caused electroencephalographic alterations consisting of spikes and epileptic discharges that began in the hippocampus and evolved to the cortex. The following motor signs were observed: movements of facial...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Scorpion fractions; Electroshock; Seizure; Neurodegeneration; EEG record; Hippocampus; Tityus serrulatus.
Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-79302000000200008
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EFFECTS OF SCORPION Tityus serrulatus VENOM TOXIN TS-8F ON RAT LEARNING AND MEMORY J. Venom. Anim. Toxins
MARUO,V. M.; LEBRUN,I.; DORCE,V. A. C..
Scorpion venom neurotoxins are responsible for toxicity and pharmacological effects. They are active in sodium and potassium channels leading to an increase in the release of neurotransmitters, such as glutamate. Glutamate is found in large quantities in the hippocampus (HPC) and is involved in the long-term potentiation (LTP) induction. The HPC is known to be related to certain kinds of memory. The aim of this study is to evaluate the effects of Tityus serrulatus TS-8F toxin on rat behavior with emphasis on learning and memory. We analyzed the effects of different doses of TS-8F on rat behavior in home cages, open-field (habituation), inhibitory avoidance, T-maze, and hippocampus morphology. In the first two experiments, 0.05µg/animal dose of TS-8F did...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Learning and memory; Scorpion neurotoxin; Tityus serrulatus; T-maze; Open-field; Passive avoidance; TS-8F toxin.
Ano: 2002 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-79302002000100007
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Embriotoxic effects of maternal exposure to Tityus serrulatus scorpion venom J. Venom. Anim. Toxins incl. Trop. Dis.
Barão,A. A. S.; Nencioni,A. L. A.; Dorce,V. A. C..
Tityus serrulatus is the most venomous scorpion in Brazil; however, it is not known whether its venom causes any harm to the offspring whose mothers have received it. This study investigates whether the venom of T. serrulatus may lead to deleterious effects in the offspring, when once administered to pregnant rats at a dose that causes moderate envenomation (3mg/kg). The venom effects were studied on the 5th and on the 10th gestation day (GD5 and GD10). The maternal reproductive parameters of the group that received the venom on GD5 showed no alteration. The group that received the venom on GD10 presented an increase in post-implantation losses. In this group, an increase in the liver weight was also observed and one-third of the fetuses presented...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Scorpion venom; Perinatal; Tityus serrulatus; Pregnancy; Embryofetotoxicity.
Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992008000200010
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Hematological and biochemical profiles of rats submitted to experimental poisoning with Tityus serrulatus venom Arq. Bras. Med. Vet. Zootec.
Pinto,M.C.L.; Melo,M.M.; Costa,M.E.R.; Labarrere,C.R..
The hematological and biochemical profiles of newly weaned rats submitted to experimental poisoning with T. serrulatus venom were evaluated. Fifteen recently weaned male Wistar rats (mean weight 130g) were distributed into three equal groups (n = 5). Animals in the control group (group A) received a subcutaneous injection of 400μL of ultra-pure water, while those in the experimental groups received, by identical route, 400μL of a solution containing 100μg (group B) or 450μg (group C) of scorpion venom dissolved in ultra-pure water. Red blood cells indexes, and differential leukocyte and total platelet counts were determined, together with levels of serum glucose, urea, creatinine, lactic dehydrogenase, aspartate aminotransferase, amylase, insulin, and...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Rat; Tityus serrulatus; Scorpion; Experimental envenoming; Hematology; Biochemestry.
Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352010000200015
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Hemograma de cães submetidos ao envenenamento experimental por Tityus serrulatus Arq. Bras. Med. Vet. Zootec.
Ribeiro,E.L.; Melo,M.M.; Pinto,M.C.L.; Labarrère,C.R.; Guimarães,P.T.C.; Paes,P.R.O.; Leme,F.O.P..
Avaliou-se o hemograma de 12 cães adultos, saudáveis (14,2±5,4kg) após a inoculação de veneno do escorpião amarelo (Tityus serrulatus). Os animais foram distribuídos em dois grupos (G), com seis em cada: os do GI foram usados como controle e receberam 0,5mL de salina tamponada com fosfato (PBS) por via subcutânea (SC) na face medial da coxa esquerda (FMCE), e os do GII receberam veneno liofilizado do T. serrulatus (250µg/kg) diluído em PBS por via SC na FMCE. Foram realizadas colheitas de sangue com anticoagulante EDTA a 10% antes da inoculação do veneno (T0) e após 2h, (T1), 6h (T2), 12h (T3), 24h (T4), 48h (T5) e 72h (T6), para contagem de eritrócitos, leucócitos e plaquetas em aparelho contador eletrônico e esfregaços sanguíneos para contagem...
Tipo: Info:eu-repo/semantics/report Palavras-chave: Cão; Escorpionismo; Tityus serrulatus; Hematologia.
Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352009000100019
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Induction of neutralizing antibodies in mice immunized with scorpion toxins detoxified by liposomal entrapment BJMBR
The possibility of producing neutralizing antibodies against the lethal effects of scorpion toxins was evaluated in the mouse model by immunization with an immunogen devoid of toxicity. A toxic fraction (5 mg) from the venom of the scorpion Tityus serrulatus was entrapped in sphingomyelin-cholesterol liposomes. The liposomes were treated for 1 h at 37oC with a 1% (w/w) trypsin solution in 0.2 M sodium carbonate buffer, pH 8.3. This treatment led to a strong reduction in venom toxicity. Immunization was performed as follows: mice were injected sc with 20 µg of the liposome-entrapped toxic fraction on days 1 and 21 and a final injection (20 µg) was administered ip on day 36. After injection of the immunogen, all mice developed an IgG response which was shown...
Palavras-chave: Liposomes; Neutralizing antibodies; Tityus serrulatus; Immunization; Toxins.
Ano: 1997 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997000700010
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Notas sobre a ocorrência de Tityus serrulatus Lutz & Mello, 1922 (Scorpiones, Buthidae) no oeste do Rio Grande do Sul, Brasil Biota Neotropica
Bortoluzzi,Luis Roberval; Querol,Marcus Vinícius Morini; Querol,Enrique.
O escorpião amarelo Tityus serrulatus é registrado pela primeira vez para oeste do Rio Grande do Sul. Foram coletados dois espécimes no município de Uruguaiana (29° 45' 23'' S e 57° 05' 37'' W) em junho de 2006. A ocorrência dos espécimes de T. serrulatus no Rio Grande Sul representa um aumento de 2.127 km em sua área de distribuição conhecida.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Tityus serrulatus; Escorpião amarelo; Distribuição; Rio Grande do Sul.
Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1676-06032007000300036
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Partial purification and functional characterization of Ts19 Frag-I, a novel toxin from Tityus serrulatus scorpion venom J. Venom. Anim. Toxins incl. Trop. Dis.
Lima,Priscila C.; Bordon,Karla C. F.; Pucca,Manuela B.; Cerni,Felipe A.; Zoccal,Karina F.; Faccioli,Lucia H.; Arantes,Eliane C..
Abstract Background The yellow scorpion Tityus serrulatus (Ts) is responsible for the highest number of accidents and the most severe scorpion envenoming in Brazil. Although its venom has been studied since the 1950s, it presents a number of orphan peptides that have not been studied so far. The objective of our research was to isolate and identify the components present in the fractions VIIIA and VIIIB of Ts venom, in order to search for a novel toxin. The major isolated toxins were further investigated for macrophage modulation. Methods The fractions VIIIA and VIIIB, obtained from Ts venom cation exchange chromatography, were rechromatographed on a C18 column (4.6 × 250 mm) followed by a reversed-phase chromatography using another C18 column (2.1 ×...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Β-KTx; Cytokine; Interleukin; Neurotoxin; Pro-inflammatory; Scorpion venom; Tityus serrulatus.
Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992015000100353
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Proteínas do soro sanguíneo de cães inoculados com veneno de Tityus serrulatus Arq. Bras. Med. Vet. Zootec.
Ribeiro,E.L.; Melo,M.M..
Protein profile of twelve healthy adult dogs averaging 14.2±5.4kg was evaluated after the inoculation of yellow scorpion venom (Tityus serrulatus). The animals were randomly divided in two experimental groups (G) (n= 6): GI control, which received 0.5mL of phosphate buffered saline (PBS) subcutaneously in the medial side of the left thigh (MSLT), and GII which received T. serrulatus venom (250μg/kg), diluted in 0.5mL of PBS subcutaneously in the MSLT. Blood samples were collected before the venom inoculation (time zero) and after 2, 6, 12, 24, 48 and 72h to obtain serum for measurement of total proteins. The fractionated protein profile was done by electrophoresis on agarose films using Tris and Amido Black staining and quantification of albumin and...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Cão; Proteína total; Albumina; Globulinas; Tityus serrulatus.
Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352012000100031
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Proteome of fraction from Tityus serrulatus venom reveals new enzymes and toxins J. Venom. Anim. Toxins incl. Trop. Dis.
Amorim,Fernanda Gobbi; Longhim,Heloisa Tavoni; Cologna,Camila Takeno; Degueldre,Michel; Pauw,Edwin De; Quinton,Loïc; Arantes,Eliane Candiani.
Abstract Background: Tityus serrulatus venom (Ts venom) is a complex mixture of several compounds with biotechnological and therapeutical potentials, which highlights the importance of the identification and characterization of these components. Although a considerable number of studies have been dedicated to the characterization of this complex cocktail, there is still a limitation of knowledge concerning its venom composition. Most of Ts venom studies aim to isolate and characterize their neurotoxins, which are small, basic proteins and are eluted with high buffer concentrations on cation exchange chromatography. The first and largest fraction from carboxymethyl cellulose-52 (CMC-52) chromatography of Ts venom, named fraction I (Fr I), is a mixture of...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Tityus serrulatus; Scorpion venom; Enzymes; Proteases; ACE inhibitors; Proteome.
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992019000100308
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Scorpions from the primeval subgenus Archaeotityus produce putative homologs of Tityus serrulatus toxins active on voltage-gated sodium channels J. Venom. Anim. Toxins incl. Trop. Dis.
Borges,A; Jowers,MJ; Bónoli,S; De Sousa,L.
It has been proposed that the subgenus Archaeotityus comprises the most ancient species group within the medically important scorpion genus Tityus. cDNA encoding sodium-channel active toxins from the type species of this subgenus, Tityus clathratus (central Venezuela), have been isolated and sequenced. Two cDNAs were retrieved that encoded 61 amino acid-long putative neurotoxins named Tcl1 and Tcl2. Sequence identity was highest (87%) when both were compared with β-toxin Ts1 from the Brazilian scorpion Tityus serrulatus and its homologs from T. bahiensis, T. stigmurus, and T. costatus. A Bayesian analysis indicated statistical support for the grouping of T. clathratus Tcl1 and Tcl2 with Brazilian gamma-like β-toxins, reinforcing previous phylogenetic...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Archaeotityus; Scorpions; Scorpion toxins; Tityus; Tityus clathratus; Tityus serrulatus.
Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992012000400012
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Selection of environmental temperature by the yellow scorpion Tityus serrulatus Lutz & Mello, 1922 (Scorpiones, Buthidae) J. Venom. Anim. Toxins incl. Trop. Dis.
Hoshino,K.; Moura,A. T. V.; De Paula,H. M. G..
The preferred temperature of the yellow scorpion Tityus serrulatus was investigated since its dispersion is a matter of concern. Adult T. serrulatus, weighing 1.24 + 0.20 g (mean + sd) and with a standard length of 59.3 + 2.5 mm, were used. A metallic corridor (120 cm long, 5 cm large and 10 cm high) with thermal gradient ranging from 0°C to 40°C was used. Tityus serrulatus chose and stayed in temperatures ranging from 14°C to 38°C when safe conditions were offered (dark and thigmotactic stimuli). The number of animals that remained in the 11°C-20°C, 21°C-30°C, and 31°C-40°C temperature zones were 8, 8, and 9, respectively. The chi-square test (degree of freedom = 2) showed that differences were not significant (p>0.05). Some animals moved to lower...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Tityus serrulatus; Scorpion; Temperature; Thermal gradient; Zoogeography.
Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992006000100005
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THE EVOLUTION OF SCORPIONISM IN BRAZIL IN RECENT YEARS J. Venom. Anim. Toxins
LOURENÇO,W. R.; CLOUDSLEY-THOMPSON,J. L.; CUELLAR,O.; EICKSTEDT,V. R. D. VON; BARRAVIERA,B.; KNOX,M. B..
In this paper further information concerning the ecological and biogeographical aspects of scorpionism is presented. Some of the information already outlined in three previous publications(10,14,16) is assessed, and new data given concerning the pattern of distribution presented by Tityus serrulatus in Brazil. Some new ideas are also proposed regarding the possible evolutionary advantages and disadvantages of parthenogenesis versus sexuality in both the short-term and the long-term.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Scorpionism; Brazil; Tityus serrulatus.
Ano: 1996 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-79301996000200005
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Tityus serrulatus envenoming in non-obese diabetic mice: a risk factor for severity J. Venom. Anim. Toxins incl. Trop. Dis.
Oliveira,Guilherme Honda de; Cerni,Felipe Augusto; Cardoso,Iara Aimê; Arantes,Eliane Candiani; Pucca,Manuela Berto.
Abstract Background In Brazil, accidents with venomous animals are considered a public health problem. Tityus serrulatus (Ts), popularly known as the yellow scorpion, is most frequently responsible for the severe accidents in the country. Ts envenoming can cause several signs and symptoms classified according to their clinical manifestations as mild, moderate or severe. Furthermore, the victims usually present biochemical alterations, including hyperglycemia. Nevertheless, Ts envenoming and its induced hyperglycemia were never studied or documented in a patient with diabetes mellitus (DM). Therefore, this is the first study to evaluate the glycemia during Ts envenoming using a diabetic animal model (NOD, non-obese diabetic). Methods Female mice (BALB/c...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Tityus serrulatus; Diabetes mellitus; Scorpion venom; NOD mice; Glycemia.
Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992016000100319
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