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2-Styrylchromones as novel inhibitors of xanthine oxidase. A structure-activity study IPB - Escola Superior Agrária
Fernandes, Eduarda; Carvalho, Félix; Silva, Artur; Santos, Clementina M.M.; Pinto, Diana; Cavaleiro, José; Bastos, Maria de Lourdes.
The purpose of this study was the evaluation of the xanthine oxidase (XO) inhibition produced by some synthetic 2-styrylchromones. Ten polyhydroxylated derivatives with several substitution patterns were synthesised, and these and a positive control, allopurinol, were tested for their effects on XO activity by measuring the formation of uric acid from xanthine. The synthesised 2-styrylchromones inhibited xanthine oxidase in a concentration-dependent and non-competitive manner. Some IC50 values found were as low as 0.55mM, which, by comparison with the IC50 found for allopurinol (5.43 mM), indicates promising new inhibitors. Those 2-styrylchromones found to be potent XO inhibitors should be further evaluated as potential agents for the treatment of...
Tipo: Article Palavras-chave: 2-styrylchromones; Allopurinol; Benzopyrone; Xanthine oxidase inhibition.
Ano: 2002 URL: http://hdl.handle.net/10198/3931
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Specific bioassays with selected plants of Bangladesh Plantas Medicinales
Guerrero,Ricardo O; Mahmud,T; Khan,H; Casañas,Bárbara; Morales,Mara.
Summary Bangladesh is an Asian country where only 20 per cent of the people are provided with modern healthcare services while the rest 80 per cent are dependent on traditional plant-based systems. Moreover, it is estimated that only 500 medicinal plant species had been recorded in Bangladesh out of 1,900 species regarded as having medicinal value. Purpose: Sixteen collections of medicinal plants of different families were extracted with several solvents (Ethanol 95%, water, chloroform, ethyl ether). The resulting extracts were subjected to five different specific bioassays: 1. Brine shrimp lethality test; 2. Antioxidant activity; 3. Inhibition of xanthine oxidase (XO); 4. Inhibition of ß-glucosidase, and 5. Inhibition of acetylcholinesterase. Methods....
Tipo: Journal article Palavras-chave: Bangladesh; Plant extracts; Brine shrimp lethality test; Antioxidant activity; Xanthine oxidase inhibition; SS-glucosidase inhibition; Acetylcholinesterase inhibition.
Ano: 2004 URL: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1028-47962004000200009
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