Data/hora: 15/06/2024 21:11:27

Provedor de dados: | 17
País: | United Kingdom
Título: | Effect of 2-H and 18-O water isotopes in kinesin-1 gliding assay
Autores: | Andy Maloney; Lawrence J. Herskowitz; Steven J. Koch.
Data: | 2012-03-20
Ano: | 2012
Palavras-chave: | Molecular Cell Biology.
Resumo: | We show here the effects of heavy-hydrogen water (^2^H~2~O) and heavy-oxygen water (H~2~^18^O) on the gliding speed of microtubules on kinesin-1 coated surfaces. Increased fractions of isotopic waters used in the motility solution decreased the gliding speed of microtubules by a maximum of 21% for heavy-hydrogen and 5% for heavy-oxygen water. We discuss possible interpretations of these results and the importance for future studies of water effects on kinesin and microtubules. We also discuss the implication for biomolecular devices incorporating molecular motors.
Tipo: | Manuscript

Identificador:

http://precedings.nature.com/documents/7004/version/1

oai:nature.com:10101/npre.2012.7004.1

http://hdl.handle.net/10101/npre.2012.7004.1

Fonte: | Nature Precedings
Fonte: | Creative Commons Attribution 3.0 License