Data/hora: 06/06/2024 01:25:52

Provedor de dados: | 17
País: | United Kingdom
Título: | The activating receptors 2B4 and NTB-A, but not CRACC are subject to ligand-induced down-regulation on human natural killer cells
Autores: | Stephan Meinke; Carolin B&amp;#xf6;hm; Sibel Durlanik; Carsten Watzl.
Data: | 2010-09-17
Ano: | 2010
Palavras-chave: | Immunology.
Resumo: | Activation of natural killer cells can be mediated by different receptors. Stimulation of the receptors 2B4, NTB-A and CRACC, members of the SLAM-related receptor family, induces cytotoxicity and cytokine production. The surface expression of 2B4 and other activating natural killer cell receptors is down-modulated after receptor engagement, which results in a weaker response to consecutive stimulation. We tested whether this regulatory mechanism applies to all SLAM-related receptors expressed by primary human natural killer cells. After co-culture with target cells expressing the respective ligands different effects on receptor surface expression were observed. While 2B4 ex-pression was strongly reduced, NTB-A showed less prominent down-modulation and the expression level of CRACC remained unchanged. The expression levels of the receptor-proximal signaling molecules SAP, EAT-2 and FynT did not change after receptor engagement. Co-culture with target cells expressing the ligands for NTB-A or CRACC had no impact on subsequent NTB-A or CRACC-mediated NK cell activation.
Tipo: | Manuscript

Identificador:

http://precedings.nature.com/documents/4917/version/1

oai:nature.com:10.1038/npre.2010.4917.1

http://dx.doi.org/10.1038/npre.2010.4917.1

Fonte: | Nature Precedings
Fonte: | Creative Commons Attribution 3.0 License