Data/hora: 16/06/2024 06:23:12

Provedor de dados: | 17
País: | United Kingdom
Título: | Self-organization of intrinsically disordered proteins with folded N-termini
Autores: | Philip C. Simister; Fred Schaper; Nicola O&amp;#x27;Reilly; Simon McGowan; Stephan M. Feller.
Data: | 2010-10-26
Ano: | 2010
Palavras-chave: | Cancer; Immunology; Molecular Cell Biology; Bioinformatics; Evolutionary Biology.
Resumo: | Thousands of human proteins lack recognizable tertiary structure in most of their chains. Here we hypothesize that some use their structured N-terminal domains (SNTDs) to organise the remaining protein chain via intramolecular interactions, generating partially structured proteins. This model has several attractive features: as protein chains emerge, SNTDs form spontaneously and serve as nucleation points, creating more compact shapes. This reduces the risk of protein degradation or aggregation. Moreover, an interspersed pattern of SNTD-docked regions and free loops can coordinate assembly of sub-complexes in defined loop-sections and enables novel regulatory mechanisms, for example through posttranslational modifications of docked regions.
Tipo: | Manuscript

Identificador:

http://precedings.nature.com/documents/5124/version/1

oai:nature.com:10101/npre.2010.5124.1

http://hdl.handle.net/10101/npre.2010.5124.1

Fonte: | Nature Precedings
Fonte: | Creative Commons Attribution 3.0 License