Data/hora: 05/06/2024 17:10:48

Provedor de dados: 	17	
País: 	United Kingdom	
Título: 	HBsAg-vectored DNA vaccines elicit concomitant protective responses to multiple CTL epitopes relevant in human disease.	
Autores: 	Dekun Chen; Allan Gould; Michael Mather; Oscar Haigh; Melanie Barnes; Jacqueline Kattenbelt; Scott Thomson; Robert R. Tindle.	
Data: 	2008-05-26	
Ano: 	2008	
Palavras-chave: 	Biotechnology; Cancer; Immunology.	
Resumo: 	Vaccines capable of controlling neoplastic and infectious diseases which depend on the cellular immune response for their resolution, have proven difficult to develop. We, and others, have previously demonstrated that the potent immunogenicity of hepatitis B surface antigen (HBsAg), the already- licensed human vaccine for hepatitis B infection, may be exploited to deliver foreign antigens for cytotoxic T-lymphocyte (CTL) induction. In this study we demonstrate that recombinant (r) HBsAg DNA delivering a CTL polyepitope appended at the C&amp;#x27; terminus elicits concomitant responses to multiple epitopes restricted through a diversity of MHC class I haplotypes, which are relevant in a number of human diseases. We show that the rHBsAg DNA vaccine elicits concomitant protection against neoplastic and infectious disease. These studies vindicate the use of HBsAg as a powerful vector to deliver CTL responses to foreign antigens, and have implications for a multi-disease vaccine applicable to the HLA-polymorphic human population.	
Tipo: 	Manuscript	
Identificador: 	http://precedings.nature.com/documents/1910/version/1

oai:nature.com:10101/npre.2008.1910.1

http://hdl.handle.net/10101/npre.2008.1910.1	
Fonte: 	Nature Precedings	
Fonte: 	Creative Commons Attribution 3.0 License