Data/hora: 16/06/2024 11:26:19

Provedor de dados: 	17	
País: 	United Kingdom	
Título: 	Spontaneous glomerular deposition of immunoglobulins for ACE (Angiotensin Converting Enzyme) induces spontaneous nephropathy in diabetogenic rats	
Autores: 	Seikoh Nishida; Tamaki Sasaki; Yasushi Hirokawa; Michihiro Matsuki; Tsutomu Nohno.	
Data: 	2009-05-23	
Ano: 	2009	
Palavras-chave: 	Immunology.	
Resumo: 	We first discovered autoantibodies to ACE (angiotensin converting enzyme) in patients with type 2 diabetes mellitus^1^. The antibodies were positive for 64.5% of the patients with diabetes and were positive in 83.3% in the early stage of clinical diabetic nephropathy. In addition, in genetically diabetogenic OLETF (Otsuka Long-Evans Tokushima Fatty) rats^2^, one of the characteristics of which strain is spontaneous nephropathy resembling those of human type 2 diabetes, and in control LETO rats^2^, immunization with rabbit lung ACE developed glomerulopathy similar to that seen in diabetics^3^. Also, in normal New Zealand white rabbits, immunization with the rabbit lung ACE induced glomerular changes similar to those seen in diabetic nephropathy^3^. In this study, renal tissues identical to those examined in research of diabetic nephropathy by PAS staining and electron microscope in preceding study^3^, were examined by immunostaining methods, only to prove that the diabetic glomerular changes may occur by immunization with ACE, not by non-specific responses to ACE, in non-diabetogenic rats and rabbits.	
Tipo: 	Manuscript	
Identificador: 	http://precedings.nature.com/documents/3275/version/1

oai:nature.com:10101/npre.2009.3275.1

http://hdl.handle.net/10101/npre.2009.3275.1	
Fonte: 	Nature Precedings	
Fonte: 	Creative Commons Attribution 3.0 License