Data/hora: 06/06/2024 04:33:03

Provedor de dados: 	17	
País: 	United Kingdom	
Título: 	Aggregation of Single Nucleotide Polymorphisms in a Human H5N1 Clade 2.2 Hemagglutinin	
Autores: 	Henry L. Niman; Magdi D. Saad; Jeffery Tjaden; Kenneth C. Earhart; Marshall R. Monteville; Mona M. Aly; Moustafa M. Mansour; Nasr El-Sayed; Ahmed E. Nayel; Ahmed S. Abdelghani; Hala M. Esmat; Emad M. Labib; Ehab A. Ayoub; Abdelattar Arafa; Gregory A. Raczniak; Mensah Agyen-Frempong; William K. Ampofo; Bruce R. Boynton.	
Data: 	2007-09-10	
Ano: 	2007	
Palavras-chave: 	Genetics &amp; Genomics; Evolutionary Biology.	
Resumo: 	The rapid evolution of the H5N1 serotype of avian influenza has been explained by a mechanism involving the selection of single nucleotide polymorphisms generated by copy errors.  The recent emergence of H5N1 Clade 2.2 in fifty countries, offered a unique opportunity to view the acquisition of new polymorphism in these evolving genomes.  We analyzed the H5N1 hemagglutinin gene from a fatal human case from Nigeria in 2007.  The newly emerged polymorphisms were present in diverse H5N1 isolates from the previous year.  The aggregation of these polymorphisms from clade 2.2 sub-clades was not supported by recent random mutations, and was most easily explained by recombination between closely related sequences.	
Tipo: 	Manuscript	
Identificador: 	http://precedings.nature.com/documents/743/version/2

oai:nature.com:10101/npre.2007.743.2

http://hdl.handle.net/10101/npre.2007.743.2	
Fonte: 	Nature Precedings	
Fonte: 	Creative Commons Attribution 3.0 License