Data/hora: 06/06/2024 01:31:45

Provedor de dados: | 17
País: | United Kingdom
Título: | Aggregation of Single Nucleotide Polymorphisms in a Human H5N1 Clade 2.2 Hemagglutinin
Autores: | Henry L. Niman; Magdi D. Saad; Jeffery Tjaden; Kenneth C. Earhart; Marshall R. Monteville; Mona M. Aly; Moustafa M. Mansour; Nasr El-Sayed; Ahmed E. Nayel; Ahmed S. Abdelghani; Hala M. Esmat; Emad M. Labib; Ehab A. Ayoub; Abdelattar Arafa; Gregory A. Raczniak; Mensah Agyen-Frempong; William K. Ampofo; Bruce R. Boynton.
Data: | 2007-09-10
Ano: | 2007
Palavras-chave: | Genetics &amp; Genomics; Evolutionary Biology.
Resumo: | The rapid evolution of the H5N1 serotype of avian influenza has been explained by a mechanism involving the selection of single nucleotide polymorphisms generated by copy errors.  The recent emergence of H5N1 Clade 2.2 in fifty countries, offered a unique opportunity to view the acquisition of new polymorphism in these evolving genomes.  We analyzed the H5N1 hemagglutinin gene from a fatal human case from Nigeria in 2007.  The newly emerged polymorphisms were present in diverse H5N1 isolates from the previous year.  The aggregation of these polymorphisms from clade 2.2 sub-clades was not supported by recent random mutations, and was most easily explained by recombination between closely related sequences.
Tipo: | Manuscript

Identificador:

http://precedings.nature.com/documents/743/version/2

oai:nature.com:10101/npre.2007.743.2

http://hdl.handle.net/10101/npre.2007.743.2

Fonte: | Nature Precedings
Fonte: | Creative Commons Attribution 3.0 License